High-precision spatiotemporal three-dimensional ultrashort pulse synchronization with optical Kerr effect.

In studying the interaction of multiple ultrashort pulses with matter, high requirements are put forward for spatiotemporal synchronization accuracy. Limited by the response time and bandwidth of existing devices, the synchronization of multiple ultrashort pulses still faces significant difficulties. By observing the transient phenomena of the optical Kerr effect, high-precision, three-dimensional (x, y, t) synchronization of ultrashort pulses at different angles was achieved. In the optical Kerr effect, the polarization state of the signal pulse changes only when it coincides with the pump pulse, at which point the signal pulse passes through the analyzer. The changes in the intensity and phase of the signal pulse is positively correlated with the degree of spatiotemporal coincidence. In this study, 10-ps pulses were used in the experiments. By observing the intensity and phase distribution of the signal pulses, a time synchronization accuracy between two pulses of less than 1 ps and spatial synchronization accuracy of ±125 µm and ±3 µm in the x and y directions, respectively, were achieved. Moreover, the synchronization of two pulses at an angle of 90 ° was measured, further proving that the method can achieve the spatiotemporal synchronization of pulses with large angles. Therefore, this method has important application prospects in the study of multi-beam interactions with matter and other ultrafast physical phenomena.

Single-Shot Intensity- and Phase-Sensitive Compressive Sensing-Based Coherent Modulation Ultrafast Imaging.

Ultrafast imaging can capture the dynamic scenes with a nanosecond and even femtosecond temporal resolution. Complementarily, phase imaging can provide the morphology, refractive index, or thickness information that intensity imaging cannot represent. Therefore, it is important to realize the simultaneous ultrafast intensity and phase imaging for achieving as much information as possible in the detection of ultrafast dynamic scenes. Here, we report a single-shot intensity- and phase-sensitive compressive sensing-based coherent modulation ultrafast imaging technique, shortened as CS-CMUI, which integrates coherent modulation imaging, compressive imaging, and streak imaging. We theoretically demonstrate through numerical simulations that CS-CMUI can obtain both the intensity and phase information of the dynamic scenes with ultrahigh fidelity. Furthermore, we experimentally build a CS-CMUI system and successfully measure the intensity and phase evolution of a multimode Q-switched laser pulse and the dynamical behavior of laser ablation on an indium tin oxide thin film. It is anticipated that CS-CMUI enables a profound comprehension of ultrafast phenomena and promotes the advancement of various practical applications, which will have substantial impact on fundamental and applied sciences.

Is Fe the Most Active Site for Fe/N-Doped Graphdiyne?

We performed a systematic study on the activity of pristine, Fe-doped, N-doped, and Fe/N-codoped graphdiyne (GDY) for oxygen reduction reactions (ORRs). We found that the pristine GDY has a high overpotential because of the weak binding of the intermediates. The sp-hybridized N-doped GDY enhances the binding of the intermediates at the adjacent sp-hybridized C site, which greatly enhances its ORR activities with a low overpotential of 0.45 V. On the other hand, on Fe-doped GDY, the binding of the intermediates at the Fe site and its neighboring C sites becomes too strong, while the C site at the second nearest acetylene chain becomes the most active site with an overpotential of 0.43 V. In the case of Fe and N codoping, Fe and the C sites near Fe and N still bind the intermediates too strongly, and the most active site is located at the C with an optimal distance. The binding energy of OH* is an activity descriptor for Fe- and/or N-doped GDY. Based on the machine learning analysis of ΔG(OH*), both the properties of the active center (electronic and geometric properties) and its environment, especially the latter, play important roles in determining its activity. The scaling relation analysis and volcano plot suggest that Fe and N doping enhance the binding of the intermediates to different extents, and the C atom, which is bonded neither to N nor to Fe atom, with an optimal binding strength, becomes the most active site.

Mitigation of electromagnetic pulses interfering with Thomson parabola ion spectrometers at XG-III laser facility.

The Thomson parabola ion spectrometer is vulnerable to intense electromagnetic pulses (EMPs) generated by a high-power laser interacting with solid targets. A metal shielding cage with a circular aperture of 1 mm diameter is designed to mitigate EMPs induced by a picosecond laser irradiating a copper target in an experiment where additionally an 8-ns delayed nanosecond laser is incident into an aluminum target at the XG-III laser facility. The implementation of the shielding cage reduces the maximum EMP amplitude inside the cage to 5.2 kV/m, and the simulation results indicate that the cage effectively shields electromagnetic waves. However, the laser-accelerated relativistic electrons which escaped the target potential accumulate charge on the surface of the cage, which is responsible for the detected EMPs within the cage. To further alleviate EMPs, a lead wall and an absorbing material (ECCOSORB AN-94) were added before the cage, significantly blocking the propagation of electrons. These findings provide valuable insights into EMP generation in large-scale laser infrastructures and serve as a foundation for electromagnetic shielding design.

Variables related to bronchopulmonary dysplasia severity: a Six-Year retrospective study.

OBJECTIVES: This was a retrospective observational study conducted in a tertiary neonatal intensive care unit, in order to investigate factors which influenced the severity of bronchopulmonary dysplasia under NICHD new classification. METHODS: Six years of clinical data with different grades of bronchopulmonary dysplasia patients were collected and analyzed, bivariate ordinal logistic regression model and multivariable ordinal logistic regression model were used with sensitivity analyses. RESULTS: We identified seven variables were associated with the severity of BPD via a bivariate ordinal logistic regression model, including the level of referral hospital (OR 0.273；95% CI 0.117, 0.636), method of caffeine administration (OR 00.418；95% CI 0.177, 0.991), more than two occurrences of reintubation (OR 4.925；95% CI 1.878, 12.915), CPAP reapplication (OR 2.255；95% CI 1.059, 4.802), presence of positive sputum cultures (OR 2.574；95% CI 1.200, 5.519), the cumulative duration of invasive ventilation (OR 1.047；95% CI 1.017, 1.078), and postmenstrual age at the discontinuation of oxygen supplementation (OR 1.190；95% CI 1.027, 1.38). These seven variables were further analyzed via all multivariable ordinal logistic regression models, and we found that tertiary hospital birth and early administration of caffeine could reduce the severity of BPD by approximately 70% (OR 0.263；95% CI 0.090, 0.770) and 60% (OR 0.371；95% CI 0.138, 0.995), respectively. In contrast, multiple reintubations were related to higher BPD severity with an OR of 3.358 (95% CI 1.002, 11.252). CONCLUSION: Improving perinatal care in level II hospitals, standardized caffeine administration, and optimized extubation strategy could potentially decrease the severity of BPD.

High-peak-power picosecond deep-UV laser sources.

Ultrafast deep-UV laser sources have extensive applications across a wide number of fields, whether biomedicine, photolithography, industrial processing, or state-of-the-art scientific research. However, it has been challenging to obtain deep-UV laser sources with high conversion efficiency and output peak power. Here, we simultaneously demonstrated high-peak-power picosecond deep-UV laser sources at two typical wavebands of 263.2 and 210.5 nm via the efficient fourth- and fifth-harmonic generation. The highest peak power of 263.2 and 210.5 nm laser radiations were up to 2.13 GW (6.72 ps) and 1.38 GW (5.08 ps). The overall conversion efficiencies from the fundamental wave to the fourth and fifth harmonic were up to 42.9% and 28.8%, respectively. The demonstrated results represent the highest conversion efficiencies and output peak powers of picosecond deep-UV laser sources at present to our knowledge. Additionally, we also systematically characterized the deep-UV optical properties of typical birefringent and nonlinear borate crystals, including α-BaB2O4, ß-BaB2O4, LiB3O5, and CsLiB6O10 crystals. The experiments and obtained numerous new optical data in this work will contribute to the generation of ultrahigh-peak-power deep-UV and vacuum-UV laser sources and crucial applications in both science and industry, such as high-energy-density physics, material science, and laser machining.

Corrigendum to "Long-term L-3-n-butylphthalide pretreatment attenuates ischemic brain injury in mice with permanent distal middle cerebral artery occlusion through the Nrf2 pathway" [Heliyon 8 (7), (July 2022), Article e09909].

[This corrects the article DOI: 10.1016/j.heliyon.2022.e09909.].

A potential pathogenic hypoxia-related gene HK2 in necrotizing enterocolitis (NEC) of newborns.

BACKGROUND: Necrotizing enterocolitis (NEC) is a disastrous gastrointestinal disease of newborns, and the mortality rate of infants with NEC is approximately 20%-30%. The exploration of pathogenic targets of NEC will be conducive to timely diagnosis of NEC. METHODS: The whole transcriptome RNA sequencing was performed on NEC samples to reveal the expression of lncRNAs, circRNAs, miRNAs and mRNAs. Using differential expression analysis, cross analysis, target prediction, enrichment analysis, the pathogenic ceRNA network and target was found. RESULTS: Preliminarily, 281 DEmRNAs, 21 DEmiRNAs, 253 DElncRNAs and 207 DEcircRNAs were identified in NEC samples compared with controls. After target prediction and cross analyses, a key ceRNA regulatory network was built including 2 lncRNAs, 4 circRNAs, 2 miRNAs and 20 mRNAs. These 20 mRNAs were significantly enriched in many carbohydrate metabolism related pathways. After cross analysis of hypoxia-, carbohydrate metabolism-related genes, and 20 core genes, one gene HK2 was finally obtained. Dendritic cells activated were significantly differentially infiltrated and negatively correlated with HK2 expression in NEC samples. CONCLUSIONS: The promising pathogenic hypoxia-related gene HK2 has been firstly identified in NEC, which might also involve in the carbohydrate metabolism in NEC.

Modulation of laser damage by temporal shaping of double picosecond pulses.

We propose a temporally shaped double-picosecond-pulse train at a sub-nanosecond scale to control the damage dynamics of optical glass. Both damage threshold and morphology are significantly modulated by pulse-train shaping. The ramp-up-shaped train effectively increases its damage threshold and decreases the damage density and size, which clearly shows that a pump pulse with optimized fluence has a strong positive modification of damage precursors. Furthermore, the temporal evolution of damage modulation is experimentally revealed by varying the interval of pump-probe pulses, and after pump exposure with optimized fluence, enhancement of the probe threshold reaches the maximum at a delay of about 260 ps.

Long-term L-3-n-butylphthalide pretreatment attenuates ischemic brain injury in mice with permanent distal middle cerebral artery occlusion through the Nrf2 pathway.

L-3-n-butylphthalide (NBP), which is used for treatment of mild and moderate acute ischemic stroke, exerts its effects by modulating the Nrf2 pathway. However, it has not been established whether NBP exerts its preventive effects in high-risk ischemic stroke patients through the Nrf2 pathway. We investigated whether NBP exerts its preventive effects through the Nrf2 pathway in long-term NBP pretreated dMCAO mice models. Nrf2+/+ wild-type and Nrf2-/- knockout mice were randomized into the vehicle group (equal volume vegetable oil), NBP-low-dose group (20 mg/kg) and NBP-high-dose group (60 mg/kg). The drug was administered once daily by gavage for a month. Then, a permanent distal middle cerebral artery occlusion model (dMCAO) was established after pretreatment with NBP. Neurological deficits, cerebral infarct volumes, brain water contents, activities of SOD, GSH-Px and MDA levels were determined. Further, axonal injury and demyelination, expression levels of Nrf2, HO-1 and NQO1 in ischemic brains were determined. Long-term NBP pretreatment significantly improved neurological functions, reduced cerebral infarction volumes, reduced brain water contents, increased SOD, GSH-Px activities, decreased MDA contents, reduced neurological injuries, axonal damage as well as demyelination, while increasing Nrf2, HO-1 and NQO1 mRNA as well as protein expressions in dMCAO mice models.

Noncritical phase-matching fourth- and fifth-harmonic generation of 1077 nm laser using KDP-family crystals.

We systematically demonstrated the angular and temperature acceptances of noncritical phase-matching (NCPM) fourth- and fifth-harmonic generation (FHG and FiHG) of a 1077 nm laser in NH4H2PO4 (ADP), KH2PO4 (KDP), and KD2PO4 (DKDP) crystals. In this work, a new, to the best of our knowledge, laser frequency with a wavelength of 1077 nm was generated by optical parametric amplification, in which the pump light (526.3 nm) was generated by the frequency doubling of a Nd:YLF laser (1052.7 nm), and the signal light was a Yb:YAG laser (1029.5 nm). Subsequently, the 1077 nm laser was used as the fundamental wave for FHG and FiHG to obtain a deep-ultraviolet laser source. For ADP and DKDP crystals, NCPM FHG of a 1077 nm laser was realized at 74.0∘C and 132.5∘C, respectively, and large angular acceptances of 59.8 and 61.6 mrad were measured. For the FiHG, NCPM was realized in a KDP crystal at 48.5∘C with an angular acceptance of 56.4 mrad. The results pave the way for high-energy and high-power deep-ultraviolet laser generation using KDP-family crystals under noncryogenic conditions.

Understanding and optimizing diffraction gratings by the blazing analysis of total internal reflection.

The diffraction grating is a classic and important optical element, and its design usually traverses the whole parameter space to search for an optimal solution, which is time consuming and inefficient. In order to specify the optimization direction of the grating to obtain clearer physical images and to improve the design efficiency, a new blazing model based on the total internal reflection (TIR) is proposed to analyze the diffraction behavior of the grating from a geometry perspective. The optical tunnel along the ridge direction can be used to understand and quantify the blaze of the grating. This TIR blazing model is demonstrated via three types of surface-relief grating with simple formulas, resulting in the solution space decreasing significantly. By utilization of the estimated upper limit of the diffraction efficiency and the range of the depth and slanted angle generated by the TIR blazing model, how the grating delivers the majority of the light energy to a required diffraction order is revealed. Binary and slanted gratings with >0.93 efficiency of T1 order have been obtained with high probability within the calculated parameter range, regardless of the duty cycle and polarization. The reason why a transmission sawtooth grating cannot blaze the most energy to a high order at normal incidence has been clarified, and the method of using the first or second TIR blaze has also been provided. Through this TIR blazing model, the grating design could be simplified, and accommodation to various application requirements could be optimized as well.

Electro-optic coefficient measurement of a K(H1-xDx)2PO4 crystal based on χ(2) nonlinear optical technology.

We present a novel method utilizing the χ(2) nonlinear optical technology, which can realize high precision measurement of linear electro-optic (EO) coefficients of nonlinear materials. By applying the linear EO effect to the nonlinear optical process, the theoretical model of this measurement method was established, and the calculation formula of the linear EO coefficient was given. In the proof-of-principle experiment, by introducing an external electric field into the fourth harmonic generation (FHG) process, we comprehensively obtained the linear EO coefficients of K(H1-xDx)2PO4 crystals and revealed the relationship between deuterium content (x) and EO coefficient (γ63): γ63 = -9.789 - 16.53x. Meanwhile, the stability of FHG was greatly improved, and the angular range of efficiency stability was increased to 4.4 times in maximum. This work not only systematically demonstrates the FHG characteristics of KDP-family crystals, which provides a good reference for the deep ultraviolet laser generation, but also offers a new way to measure the basic parameters of nonlinear optical materials.

Defect edge steepness dependence of multiple nonlinear hot-image formation from a single phase defect.

Nonlinear hot image is one of the key elements that limit the output performance of high-power laser systems. In most hot-image researches, only one hot image peak is observed in the conjugate position for a single defect. Generally, multiple hot image peaks occur for multiple defects or cascaded nonlinear media. However, a new phenomenon is found by numerical simulation in our work: one defect can also afford two hot-image peaks near the conjugate position when considering the defect edge steepness. The super-Gaussian defect model is employed to mimic the defect edge steepness. When the super-Gaussian order is higher than one, there could be two hot image peaks under certain conditions. The formation of the double hot image peaks is primarily due to the co-effect of the hard-edge diffraction and the self-focusing effect. The influence of different factors, including the super-Gaussian order, defect size, modulation depth, and Kerr medium thickness, on the double hot image peaks intensity and location is systematically investigated. The results show that with the increase in the super-Gaussian order, the intensity of the double hot image peaks increases gradually. The defect size has a great influence on the position of the two hot image peaks. The modulation depth and thickness of the Kerr medium influence the intensity of the two hot image peaks; however, they have less impact on the peak location. Importantly, the defect edge steepness and size dependences of multiple nonlinear hot-image formation from a single-phase defect are further discussed in this paper. The two hot image peaks are fatal to optical components in high-power laser systems; in particular, the hot image peak behind the conjugate position is totally unexpected for a single defect. This research provides insights into basic physical images and hot-image formation laws. It also provides important guidance for optical defect specification evaluation and optical component layout design, as well as for beam quality control, in high-power laser systems.

First-principles study on the selective hydrogenation of the C[double bond, length as m-dash]O and C[double bond, length as m-dash]C bonds of acrolein on Pt-M-Pt (M = Pt, Cu, Ni, Co) surfaces.

Selective hydrogenation of the C[double bond, length as m-dash]O and C[double bond, length as m-dash]C bonds of acrolein on Pt-M-Pt (M = Pt, Cu, Ni, Co) surfaces has been investigated with first-principles calculations to understand the trends of the activity and selectivity of the reaction. On the pristine Pt(111) surface, the results suggest that the production of allyl alcohol (a product of C[double bond, length as m-dash]O bond hydrogenation) is limited by its desorption, which results in the selective hydrogenation of the C[double bond, length as m-dash]C bond. On the other three bimetallic surfaces, the results show that the desorption of the product is no longer rate-limiting, and the reaction should be selective for the C[double bond, length as m-dash]O bond hydrogenation. Although the calculated trends of activity and selectivity agree well with the experiment, the absolute selectivity predicted on the bimetallic surfaces is in contrast with existing experiments. Therefore, other effects such as the steric effect and reactions at other types of active sites may need to be investigated. On the other hand, the scaling relation analysis shows that the formation free energies of the intermediates, except for H, scale well with that of the adsorbed acrolein. This suggests that modifying the binding of H on the surface may be another dimension for the design of more efficient catalysts for the active and selective hydrogenation of the C[double bond, length as m-dash]O bond of acrolein.

Phase defect detection of large-aperture optics with static multiplanar coherent diffraction imaging.

Phase defect detection with micrometer scale on large aperture optical elements is one of the challenges in precision optical systems. An efficient scheme is proposed to detect phase defects. First, the defects are positioned in a large aperture by dark-field imaging based on large aperture photon sieves to improve the detection efficiency with a relatively low cost. Second, static multiplanar coherent diffraction imaging is used to retrieve the phase of the positioned defects in a small field of view. Here, a spatial light modulator is used as a multifocal negative lens to eliminate the mechanical errors in multiplanar imaging. The use of a negative lens instead of a positive lens has the advantage of a larger imaging space for the system configuration. Compared to the traditional interferometry system, this diffraction detection system has a simpler optical path and doesn't require sparse distribution of the defects. Experiment results demonstrate the success of the proposed scheme with a detection resolution better than 50 µm. We believe this work provides an effective method to rapidly detect phase defects on large aperture optics with high accuracy and high resolution.

Interleukin 17 is an important pathogenicity gene in pediatric sepsis.

OBJECTIVE: Sepsis represents a complex disease with the dysregulated inflammatory response. The purpose of this study is to explore the role of interleukin 17 (IL-17, also known as IL-17A) in the occurrence and development of pediatric sepsis. METHODS: We established the sepsis neonatal rat model with the method of intraperitoneal injection of Escherichia coli (E coli). At each target time point, we got the blood from heart after anesthetizing animals, and the lung and liver tissues were fixed in formalin. Immunohistochemistry and enzyme-linked immunosorbent assay assay was used to analyze the expression of IL-17A in the lung/liver and plasma respectively. A public data set of neonatal sepsis gene microarray was used to verify our result, and explore main functions of IL-17A in sepsis. RESULTS: The expression levels of IL-17A in the plasma, lung and liver gradually increased with the extension of the experimental time in sepsis group, and were significantly higher than control group at 4 hours after injection of E coli (P < 0.01). In our study, we found the levels of IL-17A mRNA in pediatric sepsis group were significantly higher than control group, which is consistent with the neonatal rat septicemia model. In addition, through the functional (GO) enrichment analysis, we found the genes associated with IL-17A in pediatric sepsis are mainly enriched in the functions of immune response and cell membrane formation. CONCLUSION: IL-17A might be a potential therapeutic target for pediatric sepsis.

Determination of the damage growth threshold of multilayer dielectric gratings by picosecond laser pulses based on saturation damage size analysis.

We propose two efficient methods of determining damage growth threshold (DGT) based on the saturation damage size analysis (SDSA) for multilayer dielectric gratings by picosecond pulsed lasers. The damage size at laser fluences above DGT increases with the shot number and finally saturates due to the Gaussian focal spot. The DGT is extracted by mapping the boundary of a saturation damage site obtained at single fluence to the beam profile, which is called the monofluence SDSA method. Meanwhile, the saturation damage size decreases when reducing laser fluence. The fitting and extrapolation of the saturation damage sizes at different fluences are also useful to accurately determine the DGT, which is called the multifluence SDSA method. Although the saturation damage site is asymmetric, the DGTs measured with two SDSA methods are almost identical for the same axis, and both are in very good agreement with those obtained with the growth probability method. The underlying mechanisms and advantages of two SDSA methods are extensively discussed. The consistence of two SDSA methods in determining DGT is attributed to the same morphology of the initial damage and the saturation damage boundary, as well as the local damage dynamics. The relation of the lifetime damage threshold and DGT obtained with the SDSA method is also revealed.

Asymmetrical damage growth of multilayer dielectric gratings induced by picosecond laser pulses.

We experimentally investigated the laser damage growth behavior of multilayer dielectric gratings (MLDGs) by the picosecond pulses at 1053nm. The damage growth threshold of 2.43J/cm2 is significantly lower than the 20/1 damage threshold of 3.06 J/cm2. Once the damage site is initiated, the damage area grows linearly with shot number and saturates after sufficient shots due to the Gaussian spot. The barycenter of the growing damage site deviates from the laser spot center and their distance increases with the shot number, which indicates the asymmetry of the damage growth along the laser propagation axis. The growth rate of the damage site along the laser propagation direction is larger than that in the reverse direction by a factor of ~1.8 for various fluences. The comparison of the experimental and numerical results reveals that the asymmetrical intensity modulation induced by the damage sites causes the asymmetry in growth. The revealed characteristics and mechanisms of the damage growth can be of great significance to predict the lifetime of the MLDGs in high-power laser systems.

Temperature-insensitive frequency conversion by phase mismatch self-compensation in the same type of crystals.

Aiming at high-power laser frequency conversion, we present a new scheme that can self-compensate for the thermally induced phase mismatch. The basic design of the scheme is that three crystals with the same type are cascaded, of which the crystals at both ends are used for frequency conversion and the middle crystal is used for compensating phase mismatch. By configuring the polarization states of the interacting waves in the middle crystal, the sign of the first temperature derivative of the phase mismatch is opposite to that of the frequency conversion crystals. The thermally induced phase mismatch in the first crystal can thus be self-compensated in the middle crystal. To verify the utility of the proposed scheme, we experimentally demonstrated temperature-insensitive second and third harmonic generation using KH2PO4 crystals. The results show that the temperature acceptance bandwidth is about two times larger than that of using a single crystal. Since the crystals used are of the same type, this scheme has excellent universal applicability and is almost completely free from the limitations of the laser wavelength, crystal and phase-matching type. Therefore, the scheme can be widely applied to various frequency conversion processes and is scarcely any limitations.