A Lead(II) Substituted Triplet Carbene.

Reaction of the pincer-type ligand L3 supported complex [L3PbBr][BArF24] (1) with Li[(C(═N2)TMS)] furnishes [L3Pb(C(═N2)TMS)][BArF24] (2). Diazo-compound 2 eliminates dinitrogen upon irradiation affording formal plumba-alkyne 3, which persists in cold fluoroarene solutions. Variable temperature UV/Vis and NMR spectroscopies in combination with quantum-chemical calculations identify 3 as a metal-substituted triplet carbene. In-crystallo irradiation of [L3Pb(C(═N2)TMS)(tol)][BArF24] (2·tol) provides a snapshot of intermolecular C-H bond insertion with toluene (4).

A novel copper(II) complex with a salicylidene carbohydrazide ligand that promotes oxidative stress and apoptosis in triple negative breast cancer cells.

We report the synthesis, characterization, anti-cancer activity and mechanism of action of a novel water-soluble Cu(II) complex with salicylidene carbohydrazide as the ligand and o-phenanthroline as the co-ligand. The synthesized complex (1) was characterized by FT-IR, EPR, and electronic spectroscopy, as well as single crystal X-ray diffraction. This compound was found to be paramagnetic from EPR spectra and X-ray crystallography revealed that the molecule crystallized in an orthorhombic crystal system. The crystal lattice was asymmetric containing two distinct binuclear copper complexes containing the Schiff base as the major ligand, o-phenanthroline as a co-ligand, two nitrate anions, and two water molecules. The Cu(II) in the first site coordinated with the enolised ligand comprising enolate O-, phenolate O-, and the imine N and N,N from o-phen. The major part of this complex exists as Cu(II) coordinated with two H2O molecules at the second site with nitrate acting as the counter anion. However, a smaller portion of the complex exists where Cu(II) is coordinated with NO3- and H2O, and the remaining water molecule acts as lattice water. It was tested for DNA binding and cleavage properties which revealed that it binds in an intercalative mode to CT-DNA with Kb value of 1.25 × 104 M-1. Furthermore, cleavage studies reveal that the complex has potential for efficient DNA cleavage under both oxidative and hydrolytic conditions. It was able to enhance the rate of cleavage by 2.8 × 108 times. The complex shows good cytotoxicity to breast cancer monolayer (2D) as well as spheroid (3D) systems. The IC50 values for MDA-MB-231 and MCF-7 monolayer culture was calculated as 1.86 ± 0.17 µM and 2.22 ± 0.08 µM, respectively, and in (3D) spheroids of MDA-MB-231 cells, the IC50 value was calculated to be 1.51 ± 0.29 µM. It was observed that the complex outperformed cisplatin in both breast cancer cell lines. The cells treated with complex 1 underwent severe DNA damage, increased oxidative stress and cell cycle arrest which finally led to programmed cell death or apoptosis in triple negative breast cancer cells through an intrinsic pathway.

A bis-Phenolate Carbene-Supported bis-µ-Oxo Iron(IV/IV) Complex with a [FeIV(µ-O)2FeIV] Diamond Core Derived from Dioxygen Activation.

The diiron(II) complex, [(OCO)Fe(MeCN)]2 (1, MeCN = acetonitrile), supported by the bis-phenolate carbene pincer ligand, 1,3-bis(3,5-di-tert-butyl-2-hydroxyphenyl)benzimidazolin-2-ylidene (OCO), was synthesized and characterized by single-crystal X-ray diffraction, 1H nuclear magnetic resonance, infrared (IR) vibrational, ultraviolet/visible/near-infrared (UV/vis/NIR) electronic absorption, 57Fe Mössbauer, X-band electron paramagnetic resonance (EPR) and SQUID magnetization measurements. Complex 1 activates dioxygen to yield the diferric, µ-oxo-bridged complex [(OCO)Fe(py)(µ-O)Fe(O(C═O)O)(py)] (2) that was isolated and fully characterized. In 2, one of the iron-carbene bonds was oxidized to give a urea motif, resulting in an O(CNHC═O)O binding site, while the other Fe(OCO) unit remained unchanged. When the reaction is performed at -80 °C, an intensively colored, purple intermediate is observed (INT, λmax = 570 nm; ε = 5600 mol L-1 cm-1). INT acts as a sluggish oxidant, reacting only with easily oxidizable substrates, such as PPh3 or 2-phenylpropionic aldehyde (2-PPA). The identity of INT can be best described as a dinuclear complex containing a closed diamond core motif [(OCO)FeIV(µ-O)2FeIV(OCO)]. This proposal is based on extensive spectroscopic [UV/vis/NIR electronic absorption, 57Fe Mössbauer, X-band EPR, resonance Raman (rRaman), X-ray absorption, and nuclear resonance vibrational (NRVS)] and computational studies. The conversion of the diiron(II) complex 1 to the oxo diiron(IV) intermediate INT is reminiscent of the O2 activation process in soluble methane monooxygenases (sMMO). Most importantly, the low reactivity of INT supports the consensus that the [FeIV(µ-O)2FeIV] diamond core in sMMO is kinetically inert and needs to open up to terminal FeIV═O cores to react with the strong C-H bonds of methane.

Iron-Catalyzed Intermolecular C-H Amination Assisted by an Isolated Iron-Imido Radical Intermediate.

Here we report the use of a base metal complex [(tBu pyrpyrr2 )Fe(OEt2 )] (1-OEt2 ) (tBu pyrpyrr2 2- =3,5-tBu2 -bis(pyrrolyl)pyridine) as a catalyst for intermolecular amination of Csp3 -H bonds of 9,10-dihydroanthracene (2 a) using 2,4,6-trimethyl phenyl azide (3 a) as the nitrene source. The reaction is complete within one hour at 80 °C using as low as 2 mol % 1-OEt2 with control in selectivity for single C-H amination versus double C-H amination. Catalytic C-H amination reactions can be extended to other substrates such as cyclohexadiene and xanthene derivatives and can tolerate a variety of aryl azides having methyl groups in both ortho positions. Under stoichiometric conditions the imido radical species [(tBu pyrpyrr2 )Fe{=N(2,6-Me2 -4-tBu-C6 H2 )] (1-imido) can be isolated in 56 % yield, and spectroscopic, magnetometric, and computational studies confirmed it to be an S = 1 FeIV complex. Complex 1-imido reacts with 2 a to produce the ferrous aniline adduct [(tBu pyrpyrr2 )Fe{NH(2,6-Me2 -4-tBu-C6 H2 )(C14 H11 )}] (1-aniline) in 45 % yield. Lastly, it was found that complexes 1-imido and 1-aniline are both competent intermediates in catalytic intermolecular C-H amination.

The role of agostic interaction in the mechanism of ethylene polymerisation using Cr(III) half-sandwich complexes: What dictates the reactivity?

Chromium-based catalysts play a significant role in the production of ultra-high molecular weight polyethylene, and half-sandwich functionalised-metallocene complexes were proven to be one of the most suitable candidates as catalysts for generating such large polymeric-length olefins. Earlier experimental studies on olefin polymerisation using a series of catalysts such as [L1-2CrCl2] (where L1 = 1-((pyridin-2-yl)methyl)indenyl (1) and L2 = 2-methyl-1-{[4-(yridinene-1-yl)yridine-2-yl]methyl}-1H-indenyl (2)) reveal significant variation where peripheral substitution on the ligand was found to influence the reactivity significantly. However, the specific ligand position that affects the reactivity has not been established. As these reactions are fast and robust, it is challenging to establish reactive intermediates via experiments, and therefore, mechanistic clues for such reactions are elusive. Here we have undertaken a detailed computational study by employing an array of DFT (uB3LYP-D3/def2-TZVP, CASSCF/NEVPT2, and DLPNO-CCSD(T) methods to explore the substituted and non-substituted pyridine-cyclo-pentadienyl chromium complexes and their influence on the catalytic activity in ethylene polymerisation. Our study not only unravels the catalytic pathway for olefin polymerisation for such Cr(III)-half-sandwich complexes but also reveals that the energetics of the formation of pseudo-three-coordinate alkyl intermediates is key to the variation in the reactivity observed. A detailed examination using MO and NBO analysis unveils the presence of a C-H⋯Cr agostic interaction that is found to significantly stabilise this intermediate when the pyridine ligand has strong electron-donating groups at its para position. The other substitutions, such as on the cyclopentadienyl ligand, neither yield the desired stability nor the desired interaction. Further studies on models support this proposal. In order to improve the efficiency and selectivity of catalytic systems in olefin polymerisation, we strongly advocate for the integration of agostic interactions as a crucial criterion in the design of future catalysts. Considering the prevalence of electron-deficient metal centres in successful olefin polymerisation catalysts, this research prompts a broader mechanistic inquiry to propose a unified approach for this industrially crucial reaction.

Probing the Origins of Puzzling Reactivity in Fe/Mn-Oxo/Hydroxo Species toward C-H Bonds: A DFT and Ab Initio Perspective.

Activation of C-H bonds using an earth-abundant metal catalyst is one of the top challenges of chemistry, where high-valent Mn/Fe-oxo(hydroxo) biomimic species play an important role. There are several open questions related to the comparative oxidative abilities of these species, and a unifying concept that could accommodate various factors influencing reactivity is lacking. To shed light on these open questions, here, we have used a combination of density functional theory (DFT) (B3LYP-D3/def2-TZVP) and ab initio (CASSCF/NEVPT2) calculations to study a series of high-valent metal-oxo species [Mn+H3buea(O/OH)] (M = Mn and Fe, n = II to V; H3buea = tris[(N'-tert-butylureaylato)-N-ethylene)]aminato towards the activation of dihydroanthracene (DHA). The H-bonding network in the ligand architecture influences the ground state-excited state gap and brings several excited states of the same spin multiplicity closer in energy, which triggers reactivity via one of those excited states, reducing the kinetic barriers for the C-H bond activation and rationalizing several puzzling reactivity trends observed in various high-valent Mn/Fe-oxo(hydroxo) species.

Fluxionality Modulating the Magnetic Anisotropy in Lanthanoarene [(ηCnRn)2Ln(II/III)] (n = 4-8) Single-Ion Magnets.

Lanthanoarenes have emerged as the best bet for the futuristic application of single-ion magnets in information storage devices. While dysprosocenium molecules with various substituents at the arene ring exhibit a very large blocking temperature, the corresponding Er(III) analogues do not, and this is reversed if the size of the arene ring is eight. Using a combination of ab initio CASSCF and DFT-based molecular dynamics (MD) study, we have explored 25 Dy(III)/Er(III)/Ho(II)/Tb(II)/Dy(II) arene complexes with the ring size varying from 4 to 8 to understand the differences observed and decipher the correlation of structure to the spin dynamics behavior. Among the oxidation state of +2 complexes studied, Tb(II) exhibits the highest barrier, with the Cp-Tb-Cp angle being linear. Further, one of the four-membered arene model studied exhibits a very large barrier of 1442 cm-1, suggesting a potential high-blocking SIM. While bulky substituents at the arene ring help increase the axiality and the CR-Ln-CR angle, this also fetches several agostic C-H···Ln interactions, which injects transverse anisotropy. Furthermore, MD coupled with the CASSCF study reveals that the fluxional behavior of the arene ring generates several rotational conformers that are even accessible at lower temperatures offering a shortcut to the magnetization relaxation process. The importance of structural fluctuations in controlling the magnetic anisotropy by choosing apt metal-ion/ring partners and the corresponding substituents has been highlighted to offer clues to the futuristic SIM design.

Strategies to quench quantum tunneling of magnetization in lanthanide single molecule magnets.

Enhancing blocking temperature (TB) is one of the holy grails in Single Molecule Magnets(SMMs), as any future potential application in this class of molecules is directly correlated to this parameter. Among many factors contributing to a reduction of TB value, Quantum Tunnelling of Magnetisation (QTM), a phenomenon that is a curse or a blessing based on the application sought after, tops the list. Theoretical tools based on density functional and ab initio CASSCF/RASSI-SO methods have played a prominent role in estimating various spin Hamiltonian parameters and establishing the mechanism of magnetization relaxation in this class of molecules. Particularly, various strategies to quench QTM effects go hand-in-hand with experiments, and different methods proposed to quell QTM effects are scattered in the literature. In this perspective, we have explored various approaches that are proposed in the literature to quench QTM effects, and these include the role of (i) local symmetry of lanthanides, (ii) super-exchange interaction in {3d-4f} complexes, (iii) direct-exchange interaction in {radical-4f} and metal-metal bonded complexes to suppress the QTM, (iv) utilizing external stimuli such as an electric field or pressure to modulate the QTM and (v) avoiding QTM effects by stabilising toroidal states in 4f and {3d-4f} clusters. We believe the strategies summarized here will help to design new-generation SMMs.

Synthesis, Structure, and Zero-Field SMM Behavior of Homometallic Dy2, Dy4, and Dy6 Complexes.

The synthesis, structure, and magnetic properties of three DyIII complexes of different nuclearity, [Dy2(H2L)2(NO3)] [NO3]·2H2O·CH3OH (1), [Dy4(HL)2(piv)4(OH)2] (2), and [Dy6(H2L)3(µ3-OH)(µ3-CO3)3(CH3OH)4(H2O)8] 5Cl·3H2O (3) [(H4L) = 6-((bis(2-hydroxyethyl)amino)-N'-(2-hydroxybenzylidene)picolinohydrazide)], are described. This variety of complexes with the same ligand could be obtained by playing with the metal-to-ligand molar ratio, the type of DyIII salt, the kind of base, and the presence/absence of coligand. 1 is a dinuclear complex, while 2 is a tetranuclear assembly with a butterfly-shaped topology. 3 is a homometallic hexanuclear complex that exhibits a propeller-shaped topology. Interestingly, in this complex 3, three atmospheric carbon dioxide molecules are trapped in the form of carbonate ions, which assist in holding the hexanuclear complex together. All of the complexes reveal a slow relaxation of magnetization even in zero applied field. Complex 1 is a zero-field SMM with an effective energy barrier (Ueff) of magnetization reversal equal to 87(1) K and a relaxation time of τ0 = 6.4(3) × 10-9 s. Under an applied magnetic field of 0.1 T, these parameters change to Ueff = 101(3) K, τ0 = 2.5(1) × 10-9 s. Complex 2 shows zero-field SMM behavior with Ueff = 31(2) K, τ0 = 4.2(1) × 10-7 s or τ01 = 2(1) × 10-7 s, Ueff1 = 37(8) K, τ02 = 5(6) × 10-5 s, and Ueff2 = 8(4) by considering two Orbach relaxation processes, while 3, also a zero-field SMM, shows a double relaxation of magnetization [Ueff1 = 62.4(3) K, τ01 = 4.6(3) × 10-8 s, and Ueff1 = 2(1) K, τ02 = 4.6(2) × 10-5 s]. The ab initio calculations indicated that in these complexes, the Kramer's ground doublet is characterized by an axial g-tensor with the prevalence of the mJ = ±15/2 component, as well as that due to the weak magnetic coupling between the metal centers, the magnetic relaxation, which is dominated by the single DyIII centers rather than by the exchange-coupled states, takes place via Raman/Orbach or TA-QTM. Moreover, theoretical calculations support a toroidal magnetic state for complex 2.

A nonsymmetric Dy2 single-molecule magnet with two relaxation processes triggered by an external magnetic field: a theoretical and integrated EPR study of the role of magnetic-site dilution.

The 1 : 2 reaction between Dy(O2CMe)3·4H2O and 1-acetyl-2-napthol (LH) in MeOH has provided access to the complex [Dy2L6(MeOH)]·MeOH (1·MeOH) in a good yield. The structures of the isomorphous complex 1·MeOH and its doped diamagnetic yttrium analogue [Dy0.14Y1.86L6(MeOH)]·MeOH (Dy@Y2) have been determined by single-crystal X-ray crystallography and characterized based on elemental analyses, IR spectra, and powder X-ray patterns. Combined dc and ac magnetic susceptibility and the magnetization data for 1 suggest that this complex shows slow magnetic relaxation. Under a 0 Oe dc field, a single relaxation mechanism is seen while two magnetization relaxation processes are evident under a 1500 G external magnetic field. The fit to the Arrhenius law has been performed using the 1.8-10 K ac data, affording an effective barrier for the magnetization reversal of 13 K and 7 K under the external dc field. Theoretical studies have been performed using ab initio and density functional methodologies to understand the electronic structure and the magnetic relaxation dynamics resulting from the single DyIII ion as well as from the dinuclear exchange-coupled states. Rich powder EPR spectra at the X-band and Q-band were obtained from Dy@Y2, as well as from the 1·MeOH dimer, while simulation studies revealed the ferromagnetic nature of the interaction between the DyIII ions in accordance with theoretical studies.

Role of Coordination Geometry on the Magnetic Relaxation Dynamics of Isomeric Five-Coordinate Low-Spin Co(II) Complexes.

To investigate the influence of the coordination geometry on the magnetization relaxation dynamics, two geometric isomers of a five-coordinate low-spin Co(II) complex with the general molecular formula [Co(DPPE)2Cl]SnCl3 (DPPE = diphenylphosphinoethane) were synthesized and structurally characterized. While one isomer has a square pyramidal geometry (Co-SP (1)), the other isomer figures a trigonal bipyramidal geometry (Co-TBP (2)). Both complexes were already reported elsewhere. The spin state of these complexes is unambiguously determined by detailed direct current (dc) magnetic data, X-band, and high-frequency EPR measurements. Slow relaxation of magnetization is commonly observed for systems with S > 1/2. However, both 1 and 2 show field-induced slow relaxation of magnetization. Especially 1 shows relaxation times up to τ = 35 ms at T = 1.8 K, which is much longer than the reported values for undiluted Co(II) low-spin monomers. In 2, the maximal field-induced relaxation time is suppressed to τ = 5 ms. We attribute this to the change in g-anisotropy, which is, in turn, correlated to the spatial arrangement of ligands (i.e., coordination geometry) around the Co(II) ions. Besides the detailed electronic structure of these complexes, the experimental observations are further corroborated by theoretical calculations.

Are lanthanide-transition metal direct bonds a route to achieving new generation {3d-4f} SMMs?

Lanthanide based single-molecule magnets are gaining wide attention due to their potential applications in emerging technologies. One of the main challenges in this area is quenching quantum tunnelling of magnetisation (QTM), which often undercuts the magnetisation reversal barrier. Among the several strategies employed, enhancing exchange coupling has been studied in detail, with large exchanges resulting in stronger quenching of QTM effects. Lanthanides, however, suffer from weak exchanges offered by the deeply buried 4f orbitals and the numerous attempts to enhance the exchange coupling in the {3d-4f} pairs have not exceeded values larger than 30 cm-1. In this work, using a combination of DFT and the ab initio CASSCF/RASSI-SO method, we have explored lanthanide-transition metal direct bonds as a tool to quench QTM effects. In this direction, we have modelled [PyCp2LnMCp(CO)2] (Ln = Gd(III), Dy(III), and Er(III) and M = V(0), Mn(0), Co(0) and Fe(I) and here PyCp2 = [2,6-(CH2C5H3)2C5H3N]2- using [PyCp2DyFeCp(CO)2] as an example as reported by Nippe et al. (C. P. Burns, X. Yang, J. D. Wofford, N. S. Bhuvanesh, M. B. Hall and M. Nippe, Angew. Chem., Int. Ed. 2018, 57, 8144). Bonding analysis reveals a dative Ln-TM bond with a donation of π(V/Mndxy-π*CO) to 5dz2 (Gd) in the case of Gd-V and Gd-Mn and 4s(Co) to 5dxy/5dyz (Gd) for Gd-Co with the transition metal ion being found in the low-spin S = ½ configurations in all the cases. B3LYP/TZV (Gd;CSDZ) calculations on [PyCp2GdMCp(CO)2] yield JGd-V = -46.1 cm-1, JGd-Mn = -57.1 cm-1, JGd-Co = +55.3 cm-1, JGd-Fe+ = +13.9 cm-1, JGd-Vhs = -162.1 cm-1 and JGd-Mnhs = -343.9 cm-1 and unveiling record-high J values for {3d-4f} complexes. The mechanism of magnetic coupling is developed, which discloses the dominating presence of strong 3d-4f orbital overlaps in most of the cases studied, leading to antiferromagnetic exchange. When these overlaps are weaker and 3d to Gd(5dz2), charge transfer dominates, yielding a ferromagnetic coupling for the Gd-Co/Gd-Fe+ complexes. Calculations performed on the anisotropic Dy(III) and Er(III) complexes reveal that the ground state gzz axis lies along the Cp-Ln-Cp axis and the Ln-TM bonds, respectively. Thus the Ln-TM bond hinders the single-ion anisotropy of Dy(III) by offering equatorial ligation and lowering the mJ = ±½ state energy, and at the same time, helping in enhancing the axiality of Er(III). When strong {3d-4f} exchange couplings are introduced, record-high barrier heights as high as 229 cm-1 were accomplished. Furthermore, the exchange coupling annihilates the QTM effects and suggests the lanthanide-transition metal direct bond as a viable alternative to enhance exchange coupling to bring {3d-4f} complexes back in the race for high-blocking SMMs.

Quantifying magnetic anisotropy using X-ray and neutron diffraction.

In this work, the magnetic anisotropy in two iso-structural distorted tetrahedral Co(II) complexes, CoX 2tmtu2 [X = Cl(1) and Br(2), tmtu = tetra-methyl-thio-urea] is investigated, using a combination of polarized neutron diffraction (PND), very low-temperature high-resolution synchrotron X-ray diffraction and CASSCF/NEVPT2 ab initio calculations. Here, it was found consistently among all methods that the compounds have an easy axis of magnetization pointing nearly along the bis-ector of the compression angle, with minute deviations between PND and theory. Importantly, this work represents the first derivation of the atomic susceptibility tensor based on powder PND for a single-molecule magnet and the comparison thereof with ab initio calculations and high-resolution X-ray diffraction. Theoretical ab initio ligand field theory (AILFT) analysis finds the d xy orbital to be stabilized relative to the d xz and d yz orbitals, thus providing the intuitive explanation for the presence of a negative zero-field splitting parameter, D, from coupling and thus mixing of d xy and . Experimental d-orbital populations support this interpretation, showing in addition that the metal-ligand covalency is larger for Br-ligated 2 than for Cl-ligated 1.

Enhancing the barrier height for magnetization reversal in 4d/4f RuIII2LnIII2 "butterfly" single molecule magnets (Ln = Gd, Dy) via targeted structural alterations.

A series of 4d-4f {RuIII2DyIII2} and {RuIII2GdIII2} 'butterfly' (rhombohedral) complexes have been synthesized and characterized and their magnetic properties investigated. Earlier, we have reported the first 4d/4f SMM - [RuIII2DyIII2(OMe)2(O2CPh)4(mdea)2(NO3)2] (1Dy) with a Ueff value of 10.7 cm-1. As the structural distortion around the DyIII centres and the RuIII⋯DyIII exchange interactions are key to enhancing the anisotropy, in this work we have synthesised three more {Ru2Dy2} butterfly complexes where structural alteration around the DyIII centres and alterations to the bridging groups are performed with an aim to improve the magnetic properties. The new complexes reported here are [Ru2Dy2(OMe)2(O2C(4-Me-Ph)4(mdea)2(MeOH)4], 2Dy, [Ru2Dy2(OMe)2(O2C(2-Cl,4,5-F-Ph)4(mdea)2(NO3)2], 3Dy, and an acac derivative [Ru2Dy2(OMe)2(acac)4(NO3)2(edea)2], 4Dy, where acac- = acetylacetonate, edea2- = N-ethyldiethanolamine dianion. Complex 2Dy describes alteration in the DyIII centers, while complexes 3Dy and 4Dy are aimed to alter the RuIII⋯DyIII exchange pathways. To ascertain the 4d-4f exchange, the Gd-analogues of 1Dy and 4Dy were synthesised [Ru2Gd2(OMe)2(O2CPh)4(mdea)2(NO3)2], 1Gd, [Ru2Gd2(OMe)2(acac)4(NO3)2(edea)2], 4Gd. Both ac and dc susceptibility studies were performed on all these complexes, and out-of-phase signals were observed for 3Dy in zero-field while 2Dy and 4Dy show out-of-phase signals in the presence of an applied field. Complex 3Dy reveals a barrier height Ueff of 45 K. To understand the difference in the magnetic dynamic behavior compared to our earlier reported {RuIII2DyIII2} analogue, detailed theoretical calculations based on ab initio CASSCF/RASSI-SO calculations have been performed. Calculations reveal that the JRu⋯Dy value varies from -1.8 cm-1 (4Dy) to -2.4 cm-1 (3Dy). These values are also affirmed by DFT calculations performed on the corresponding GdIII analogues. The origin of the largest barrier and observation of slow magnetic relaxation in 3Dy is routed back to the stronger single-ion anisotropy and stronger JRu⋯Dy exchange which quenches the QTM effects more efficiently. This study thus paves the way forward to tune local structure around the LnIII center and the exchange pathway to enhance the SMM characteristics in other {3d-4f}/{4d-4f} SMMs.

Azide-Coordination in Homometallic Dinuclear Lanthanide(III) Complexes Containing Nonequivalent Lanthanide Metal Ions: Zero-Field SMM Behavior in the Dysprosium Analogue.

A series of homometallic dinuclear lanthanide complexes containing nonequivalent lanthanide metal centers [Ln2(LH2)(LH)(CH3OH)(N3)]·xMeOH·yH2O [1, Ln = DyIII, x = 0, y = 2; 2, Ln = TbIII, x = 1, y = 1] have been synthesized [LH4 = 6-((bis(2-hydroxyethyl)amino)-N'-(2-hydroxybenzylidene)picolinohydrazide] and characterized. The dinuclear assembly contains two different types of nine-coordinated lanthanide centers, because the nonequivalent binding of the azide co-ligand as well as the varying coordination of the deprotonated Schiff base ligand. Detailed magnetic studies have been performed on the complexes 1 and 2. Complex 1 and its diluted analogue (15%) are zero-field SMMs with effective energy barriers (Ueff) of magnetization reversal equal to 59(3) K and 66(3) K and relaxation times of τ0 = 10(4) × 10-6 s and 10(4) × 10-8 s, respectively. On the other hand, complex 2 shows a field-induced SMM behavior. Combined ab initio and density functional theory calculations were performed to explain the experimental findings and to unravel the nature of the magnetic anisotropy, exchange-coupled spectra, and magnetic exchange interactions between the two lanthanide centers.

Enantiopure Polyradical Tetrahedral Pd12 L6 Cages.

The synthesis of cages with a polyradical framework remains a challenging task. Herein is reported an enantiomeric pair of quinoid-bridged polyradical tetrahedral palladium(II) cages that are stabilized by an unusual dianionic diradical form (dhbq..2- ). These cages have been characterized by electron paramagnetic resonance and UV-visible spectroscopy, squid magnetometry and mass spectrometry. Single-crystal-derived X-ray investigations of the iso-structural cages built on fluoranilate linkers confirm the tetrahedral structure of the obtained radical cages. Theoretical calculations showed that the diradical state of the dhbq anions is more stable than the usual monoradical state. A weak ferromagnetic exchange between adjacent radical centers was observed in DFT studies.

Validation of Ab-Initio-Predicted Magnetic Anisotropies and Magneto-structural Correlations in Linear Hetero-trinuclear DyIII -NiII 2 Compounds.

Reported are single crystal SQUID and single crystal high-frequency/high-field EPR data of a trinuclear complex with a rare six-coordinate coordination sphere of a DyIII center coupled to two terminal six-coordinate NiII ions. The analysis of the single crystal spectroscopic parameters allows for an accurate description of the ground state wavefunction. The experimental analysis is supplemented by the analysis of the paramagnetic NMR spectra, allowing for a thorough description of the DyIII center. The experimental data are interpreted on the basis of an ab initio ligand field analysis, and the computed parameters are in good agreement with the experimental observations. This supports the quality of the theoretical approach based on a pseudo-spin Hamiltonian for the electronic ground state. Further support emerges from the ab initio ligand field theory based analysis of a structurally very similar system that, in contrast to the complex reported here, shows single molecule magnetic properties, and this is in agreement with the quantum-chemical prediction and analysis.

Lanthanoid pyridyl-ß-diketonate 'triangles'. New examples of single molecule toroics.

Trinuclear lanthanoid clusters have been synthesised and investigated as toroidal spin systems. A pyridyl functionalised ß-diketonate, 1,3-bis(pyridin-2-yl)propane-1,3-dione (o-dppdH) has been used to synthesise a family of clusters of the form [Dy3(OH)2(o-dppd)3Cl2(H2O)4]Cl2·7H2O (1), [Tb3(o-dppd)3(µ3-OH)2(CH3CH2OH)3Cl3][Tb3(o-dppd)3(µ3-OH)2(H2O)(CH3CH2OH)2Cl3]Cl2·H2O (2), [Ho3(OH)2(o-dppd)3Cl(H2O)5]Cl3·3H2O (3) and [Er3(OH)2(o-dppd)3Cl2(H2O)3(CH3OH)]Cl2·3H2O·CH3OH (4). Despite the previous occurrence of this structural motif in the literature, these systems have not been widely investigated in terms of torodic behaviour. Magnetic studies were used to further characterise the complexes. DC susceptibility studies support weak antiferromagnetic exchange in the complexes. Slow magnetic relaxation behaviour is observed in the dynamic AC magnetic studies for complex 1. Theoretical studies predict that complex 1 and 3 have a non-magnetic ground state based on a toroidal arrangement of spins. Changes to the coordination environment in 2 do not support a toroic spin state. The prolate nature of the ErIII centres in complex 4 and large transverse anisotropy do not support the toroidal arrangement of lanthanoid spins in the complex.

Oral versus intravenous iron therapy in iron deficiency anemia: An observational study.

BACKGROUND: Intravenous (IV) iron sucrose is claimed to have better safety profile and efficacy in treatment of iron deficiency anemia than conventional oral iron supplements. AIM: The aim of the study was to compare the efficacy and safety of IV iron therapy with oral iron supplements in iron deficiency anemia. METHODS: An observational study was carried out by allocating 100 patients with baseline hemoglobin between 5 and 10 g/dL into two groups of oral iron and IV iron group. Hemoglobin and serum ferritin levels were measured at admission, on day 14 and on day 28. Adverse effect profile for each group was tabulated. Mean and standard deviation were calculated for each group and compared. RESULTS: A total of 100 patients participated consisting of 37 males and 63 females. Baseline hemoglobin and serum ferritin for both groups were comparable. After initiation of therapy, hemoglobin in oral iron group raised from 6.45 (0.72) to 8.84 (0.47) on day 14 and to 9.69 (0.47) on day 28. Hemoglobin in IV iron group increased from 6.34 (0.86) to 10.52 (0.61) on day 14 and to 11.66 (0.84) on day 28. Serum ferritin in oral iron group increased from 8.3 (1.9) to 33.8 (1.29) on day 14 and to 43.61 (8.8) on day 28. Serum ferritin in IV iron group raised from 8.23 (4.64) to 148.23 (11.86) on day 14 but decreased to 115.76 (15.3) on day 28. The data were statistically significant for IV iron therapy on day 14 and day 28. Of 100 patients, 18 patients (12 in oral and 6 in IV iron groups) had adverse effects. Among the oral iron group, metallic taste and constipation were major side effects followed by heart burn and nausea. In the IV iron group, arthralgia (4 patients of 6) was the major side effect observed. One patient (of 6) in IV group had hypotension. Anaphylaxis was not observed in any patient in either group. CONCLUSION: IV iron therapy is effective and safe for management of iron deficiency anemia.