Translabyrinthine Excision of a Transmodiolar Intralabyrinthine Schwannoma Mimicking Meniere's Disease: A Case Report.

Intralabyrinthine schwannomas (ILSs) are rare tumors involving the otic capsule. Notably, they are often misdiagnosed because their symptoms mimic those of other, more common inner ear pathologies. Diagnosis requires high-resolution contrast-enhanced magnetic resonance imaging (MRI), which reveals filling defects (using a T2-weighted MRI sequence) or focal enhancement (using a T1-weighted MRI sequence with gadolinium enhancement) in the inner ear. A 52-year-old male patient with intractable vertigo or single-sided deafness should raise suspicion of this clinical entity as a differential diagnosis. Translabyrinthine excision of the tumor along with auditory rehabilitation using a cochlear implant can provide good outcomes with minimal morbidity in carefully selected cases. Here, we present an interesting case of a transmodiolar ILS mimicking Meniere's disease, wherein surgery using the translabyrinthine approach and an extended cochleostomy yielded favorable outcomes.

Recalcitrant Epistaxis: A case report of Hereditary Haemorrhagic Telangiectasia.

Hereditary haemorrhagic telangiectasia, also known as Rendu-Osler-Weber disease, is an autosomal dominant disorder of the fibrovascular tissue common in Western countries. It is characterized by the classical triad of mucocutaneous telangiectasia, arteriovenous malformations with recurrent epistaxis. Here we report a rare case of Hereditary haemorrhagic telangiectasia in a 66-year-old Indian male who presented with a history of recurrent epistaxis of forty years duration. The nasal telangiectasias were ablated under narrow band imaging guidance. The rarity of diagnosis was aided by clinical exome sequencing to confirm the disease.

Post Surgical Outcomes in Paediatric Adenotonsillar Hypertrophy with Obstructive Sleep Apnea: Subjective and Objective Evaluation.

The aim of the study was to determine the post surgical outcomes in pediatric adenotonsillar hypertrophy with OSA using portable polysomnography (PSG), OSA 18 Questionnaire and Quality of life (QoL) scores. Secondly to correlate the subjective outcomes with objective scores of polysomonography. A prospective, single-arm, nonrandomized, single center study was performed at a tertiary care centre on children aged 3-12 years (n = 30) with adenoid hypertrophy/ tonsillar hypertrophy/adenotonsillar hypertrophy and symptoms suggestive of OSA. All subjects underwent appropriate surgical intervention. A portable PSG and OSA 18 questionnaire evaluation was performed pre surgery and 06 weeks post surgery to assess objective and clinical assessment for OSA. The mean age of children enrolled in the study was 8.68 ± 3 years. The mean pre treatment AHI was 12.56 ± 13.16 which improved to 1.72 ± 1.53 post surgery and was statistically significant (p < 0.05, Wilcoxon signed rank test). There was a statistically significant improvement in other PSG indices such as RDI and ODI post surgery also. The mean total symptom score (TSS) and QoL score also showed a statistically significant improvement post treatment (p < 0.05). However there was no correlation between the PSG and OSA 18 questionnaire scores pre and post surgery. Children with OSA like symptoms can undergo a portable polysomnography pre and post surgery to demonstrate severity of OSA and objectively monitor improvement in OSA post treatment. In the absence of availability of PSG, OSA 18 questionnaire is a suitable alternative to monitor disease severity and outcomes. Further studies may plan to include impact of paediatric OSA on other function such as the cardiac, dentition & malocclusion and neurocognitive function.

Trends of sensitization pattern to aeroallergens among the patients with allergic rhinitis and/or bronchial asthma in Bangalore: A cross sectional study.

Background: Allergic rhinitis (AR) is rather erroneously viewed as a trivial disease. It is a chronic or recurrent allergen-specific, IgE-mediated inflammation that primarily affects the membrane lining the nose. However, due to the united airway concept, it is also found to be associated with bronchial asthma. AR commonly remains underdiagnosed or misdiagnosed and thus, leads to either undertreatment or inappropriately prolonged medication. Methods: Four hundred adults having allergic rhinitis and/or bronchial asthma, fulfilling the criteria as per Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines, underwent skin prick test (SPT). Those having rhinitis due to nonallergic causes were excluded. SPT was carried out using a customized panel of 21 aeroallergens. The result was compared with the reaction of histamine, which was taken as a positive control. Results: Majority of 228 (58.02%) of the patients showed a positive reaction to the tested panel of allergens. However, 165 (41.98%) showed no reaction to the tested panel of allergens can be due to various factors like reduced skin sensitivity, antihistaminic medications, etc. Conclusion: Skin prick test accurate test for determining offending allergens in allergic conditions. House dust mites (41%) were the most common offending aeroallergen among patients with allergic rhinitis and/or bronchial asthma residing in Bangalore. The identification of offending aeroallergens have helped patients in avoiding unnecessary medications, take appropriate preventive measures or plan appropriate immunotherapy.

Role of subjective visual vertical in patients with posterior canal benign paroxysmal positional vertigo as a prognostic marker after canalith repositioning maneuver.

Objective: To study the potential role of subjective visual vertical (SVV) as a prognostic marker for canalith repositioning maneuver (CRM) in patients with posterior canal benign paroxysmal positional vertigo (PC-BPPV) for the Indian population. Methods: SVV was examined in 30 patients with PC-BPPV before and after canalith repositioning maneuver and after complete resolution of PC-BPPV. Study parameters included the mean of 10 angular tilt readings and direction of deviation, which were compared before and after CRM and following complete resolution of PC-BPPV. Results: The angle of SVV tilt was greater and deviated towards the affected ear before CRM in all patients, which decreased significantly shortly after CRM and continued to decrease after complete resolution of PC-BPPV (p < 0.0001). Conclusions: SVV can be used to test utricular dysfunction in PC-BPPV. The angle of tilt improves in response to CRM, which may be used as a prognostic marker in patients with PC-BPPV receiving CRM.

A study on relationship between Neural Response Telemetry and behavioural Threshold/Comfort levels in children with cochlear implant.

BACKGROUND: Our study was a prospective, non-randomised, single tertiary care centre study involving 50 children below 10 years, all implanted with Nucleus 24™ cochlear implants to find the relationship between intra-operative NRT (Neural Response Telemetry) values and post-operatively behaviourally obtained Threshold (T) and Comfort (C) levels. METHODS: NRT threshold values were obtained intra-operatively by using Custom Sound EP Software V 4.4™ (Cochlear Corporation). At switch-on after three weeks, behavioural T and C levels were measured based on behavioural responses given by patients using Custom Sound Version 4.4 software™ (Cochlear Corporation). NRT values were also measured at switch-on, 2 months, 3 months and 6 months. RESULTS: Intra-operative NRT levels (187.96 ± 12.48) were higher than both T (160.63 ± 22.69) and C (181.21 ± 22.41) levels obtained after 3 weeks. In addition, there was a weak correlation of NRT values with T (P value: 0.05, r = 0.391) and C (P value: 0.05, r = 0.390) levels. CONCLUSION: NRT is a quick and non-invasive tool to confirm cochlear implant integrity. There is a weak correlation of NRT values with both T and C levels and therefore, intra-operative NRT is a weak predictor for setting both T and C levels at switch-on.

Cost-effectiveness of Pediatric Unilateral/Bilateral Cochlear Implant in a Developing Country.

OBJECTIVE: To determine the cost-effectiveness of unilateral and bilateral cochlear implantation (CI) for children suffering from bilateral profound SNHL. STUDY DESIGN: This was a cost benefit analysis study where quality-adjusted life years (QALY) and the expenditure involved post unilateral and bilateral CI were calculated to assess the cost per QALY gained. SETTING: The study was conducted in a tertiary-care hospital in a city of a developing country. PATIENTS: A total of 59 patients were studied during the years 2015 to 2019 of which a study cohort of 29 patients underwent bilateral cochlear implantation and a control cohort of 30 patients received U/L CI but did not undergo B/L CI. MAIN OUTCOME: The QALY parameters HUI3 and VAS when patient had no implant, post unilateral and bilateral CI were calculated along with the total lifelong expenditure involved. The outcomes improvement post CI was compared in the study and control groups. The discounted net cost per QALY gained was assessed and compared with the PCGDP of the country for cost effectiveness. RESULTS: Significant QALY was gained post unilateral and bilateral CI and the expenditure for both was within the cost thresholds. The net costs per QALY gained post the discounting in unilateral and bilateral CI were found to be 1,345 US$ and 1,977 US$ respectively. The PCGDP (nominal) of India in 2018 was 2,016 US$. The cost involved per QALY gained was found to be lesser than the per capita GDP of India. CONCLUSION: Unilateral CI was found to be highly cost effective with bilateral CI involving a little higher cost per QALY gained but well within the cost effectiveness threshold.

Tracheal Stenosis: Evaluation of an Institutional Protocol and Introduction of Novel Surgical Criteria and Scoring System.

Treatment modalities for treatment of post intubation and post tracheostomy tracheal stenosis are many. However, well defined surgical criteria and prognostic classification eluding us till date. A prospective study of 57 cases of post intubation and post tracheostomy tracheal stenosis managed as per well defined surgical criteria followed in our institution. Patients were divided into three groups as per the primary surgical procedure used. The stenosis was classified into mild, moderate and severe based on our proposed prognostic classification. The success rate of endoscopic procedure was 81% with average 1.6 number of procedures per patient, for tracheoplasty success rate was 63% with 1.4 number of procedure per patient, and similarly for tracheal resection and anastomosis was 90% with 1.1 procedure per patient. The patient score as per our proposed classification correlated well with the prognosis. Our surgical criteria correlates well with success rate reported by other authors and can be helpful for institutions or surgeons dealing with tracheal stenosis occasionally. Our prognostic classification can be used to predict prognosis.

A study to determine factors influencing outcomes of paediatric cochlear implants.

BACKGROUND: Cochlear implantation is a powerful tool for helping children with severe to profound sensorineural hearing loss to gain the ability to hear, achieve age appropriate communication skills. However patient selection is of utmost importance to achieve optimum results. METHOD: A cross sectional study was done on 75 children who had undergone unilateral cochlear implantation. Hearing was assessed by, The Meaningful Auditory Integration Scale (MAIS) and speech perception was assessed by the Meaningful Use of Speech Scale (MUSS) as a parent reported scale in an interview format. RESULTS: The cochlear implantation improved auditory skills and speech perception of the children who underwent cochlear implantation. Children who had less than 40 months auditory deprivation and those who had higher educated parents had better auditory skills and speech perception. CONCLUSION: Early cochlear implantation and good auditory verbal therapy have better outcomes of hearing and speech.