RESUMO
Plasma levels of total 5-aminosalicylic acid (5-ASA) were determined after a single administration of 2 g and 4 g 5-ASA enemas to 6 patients with ulcerative colitis. The mean plasma levels and AUC values confirmed that the active substance is poorly absorbed by rectal route.
Assuntos
Ácidos Aminossalicílicos/sangue , Colite Ulcerativa/metabolismo , Adulto , Ácidos Aminossalicílicos/administração & dosagem , Ácidos Aminossalicílicos/farmacocinética , Colite Ulcerativa/tratamento farmacológico , Enema , Feminino , Humanos , Masculino , Mesalamina , Pessoa de Meia-IdadeRESUMO
Thirty-nine patients with documented active distal proctitis (less than 20 cm) received either 5-aminosalicylic acid (5-ASA) enemas (2 g in 100 ml) or suppositories 1 g b.i.d., in a controlled study. Twenty patients received enemas, while 19 patients received suppositories, for 30 days. No difference could be observed in terms of efficacy; however, it was the patients' opinion that treatment with suppositories was easier than that with enemas (p less than 0.01).
Assuntos
Ácidos Aminossalicílicos/administração & dosagem , Colite Ulcerativa/tratamento farmacológico , Administração Retal , Enema , Humanos , Mesalamina , Autoadministração , SupositóriosRESUMO
A controlled trial has been carried out in order to compare the efficacy of enemas containing a high dosage of 5-ASA (4 g) versus enemas containing hydrocortisone 100 mg. The trial was conducted on 86 patients, 44 of whom received 5-ASA and 42 received hydrocortisone. The results were favorable in terms of clinical, sigmoidoscopic, and histologic criteria for 5-ASA treatment. Other aspects have been investigated, such as retrograde spread of enemas which have been shown to reach the left colon. No nephrotoxicity was detected. The long term experience confirmed the preliminary positive results.