1.
Org Lett
; 16(17): 4634-7, 2014 Sep 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25158282
RESUMO
A sequence of oxidation reactions of alkenamides with hypervalent iodine is described. Oxidation of ortho-alkenylbenzamide substrates selectively gave isochroman-1-imine products. The products underwent further oxidation in the presence of a Pd salt catalyst leading to regioselective C-H acetoxylation at the 8-position. A series of oxidations was applied to the crucial steps of asymmetric synthesis of 4-hydroxymellein derivatives.