RESUMO
PURPOSE: N-benzyl-N-methyl-2-[7, 8-dihydro-7-(2-[18F] fluoroethyl) -8-oxo-2-phenyl-9H-purin-9-yl] acetamide ([18F] FEDAC) is a novel positron emission tomography (PET) tracer that targets the translocator protein (TSPO; 18 kDa) in the mitochondrial outer membrane, which is known to be upregulated in various diseases such as malignant tumors, neurodegenerative diseases, and neuroinflammation. This study presents the first attempt to use [18F]FEDAC PET/CT and evaluate its biodistribution as well as the systemic radiation exposure to the radiotracer in humans. MATERIALS AND METHODS: Seventeen whole-body [18F]FEDAC PET/CT (injected dose, 209.1 ± 6.2 MBq) scans with a dynamic scan of the upper abdomen were performed in seven participants. Volumes of interest were assigned to each organ, and a time-activity curve was created to evaluate the biodistribution of the radiotracer. The effective dose was calculated using IDAC-Dose 2.1. RESULTS: Immediately after the intravenous injection, the radiotracer accumulated significantly in the liver and was subsequently excreted into the gastrointestinal tract through the biliary tract. It also showed high levels of accumulation in the kidneys, but showed minimal migration to the urinary bladder. Thus, the liver was the principal organ that eliminated [18F] FEDAC. Accumulation in the normal brain tissue was minimal. The effective dose estimated from biodistribution in humans was 19.47 ± 1.08 µSv/MBq, and was 3.60 mSV for 185 MBq dose. CONCLUSION: [18F]FEDAC PET/CT provided adequate image quality at an acceptable effective dose with no adverse effects. Therefore, [18F]FEDAC may be useful in human TSPO-PET imaging.
Assuntos
Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Compostos Radiofarmacêuticos , Humanos , Distribuição Tecidual , Tomografia por Emissão de Pósitrons/métodos , Proteínas de Transporte/metabolismo , Radiometria , Receptores de GABA/metabolismoRESUMO
ABSTRACT: To support estimations of early individual internal doses to residents who suffered from the 2011 accident at the Fukushima Daiichi Nuclear Power Plant (FDNPP), we have sought to use whole-body counter (WBC) measurement results of subjects who lived in municipalities neighboring the FDNPP at the time of the accident. These WBC measurements started several months after the accident; the targeted radionuclides were 134Cs and 137Cs. Our previous study had analyzed the relationship between the residual Cs contents of individuals and evacuation behaviors in the period immediately after the accident for residents of Namie-town, one of the most radiologically affected municipalities. Those results suggested that the first major release event at the FDNPP on 12 March 2011 caused significant exposure, particularly to those who delayed evacuation on that day. The present study expanded its scope to include subjects from four towns neighboring the FDNPP (Namie, Futaba, Okuma, and Tomioka) to gather additional evidence of the exposure that took place on 12 March 2011. Additionally, we investigated the relationship between individual cesium doses and subjects' destinations following the largest release event on 15 March 2011. The study population was 1,145 adults. We first divided the subjects into two evacuation groups depending on the distance from the FDNPP and their evacuation whereabouts (25-km boundary) as of 15:00 on 12 March 2011: the G1 group (≥25 km) and the G2 group (<25 km). We further divided these two subject groups into seven subgroups based on the subjects' destinations as of 0:00 on 16 March 2011. Our four main findings are as follows. (1) The 137Cs detection rate was significantly different between the G1 and G2 groups of Namie-town and Futaba-town but not for those of Okuma-town and Tomioka-town. This result corresponds to the plume passage (flowing toward the northwest to the north) in the afternoon of 12 March 2011 and supports our previous study. (2) The upper-percentile committed effective doses (CEDs) of the G2 groups were higher than those of the G1 groups for all four towns, although the between-group difference varied with the town. The highest CEDs were found in the G2 group of Futaba-town, and the lowest CEDs were in the Namie-town G1 group: 0.16 mSv and 0.04 mSv at the 90th percentile, respectively. The CEDs for both the G1 and G2 groups were relatively high for Okuma-town and Tomioka-town compared to those of the G1 group of Namie-town, although the former subjects were expected to be less exposed on 12 March 2011 and then evacuated to remote places, as did the residents of the other towns. (3) The CEDs of the G1 subgroup that evacuated outside Fukushima Prefecture were extremely low, suggesting that these subjects were little exposed on both 12 and 15 March 2011. However, the CEDs of the same G1 subgroup were rather higher than those of the corresponding G2 subgroup for Futaba-town and Okuma-town. We thus speculate that the WBC measurements were likely to have been affected by the contamination occurring in the second-round temporary re-entry (except for the Namie-town residents). (4) The analyses of the Namie-town evacuees indicated that the area including the middle and northern parts of Fukushima Prefecture was relatively more affected by the major release event on 15 March 2011. In conclusion, the early cesium intake due to the FDNPP accident remained detectable in the WBC measurements of certain present subjects; however, further analyses of the available data are necessary for a full understanding of the WBC measurement results.
Assuntos
Radioisótopos de Césio , Acidente Nuclear de Fukushima , Adulto , Humanos , Cidades , Centrais Nucleares , CésioRESUMO
In a nuclear emergency, one of the actions taken for the sake of public is to monitor thyroid exposure to radioiodines. Japan's Nuclear Regulation Authority recently published a report on such monitoring and proposed direct thyroid measurements with conventional NaI(Tl) survey meters (e.g. Hitachi model TCS-172) as a primary screening method. A previous study proposed screening levels (SLs) used in these simplified measurements as the net reading values of the TCS-172 device. Age-specific SLs were derived from a thyroid equivalent dose of 100 mSv due to the inhalation intake of 131I. This study addressed the possible influence of short-lived iodine isotopes other than 131I on the simplified measurements. In preparation for such measurements, the responses of the device for 132I as an ingrowth component from 132Te, 133I, 134I and 135I in the thyroid were evaluated by numerical simulations using age-specific stylized phantoms in addition to those obtained for 131I in the previous study. The radioactivity ratios of the relevant isotopes were taken from the inventory data of the Fukushima Daiichi Nuclear Power Plant. The results were used to predict the net readings of the device when 132Te-132I and 133I as well as 131I were inhaled at 24 or 72 h after the shutdown of a nuclear power plant. In these cases, the signals from 132Te-132I and 133I become undetectable a couple of days after intake, which could lead to underestimations of the thyroid dose. To estimate the thyroid dose accurately from the simplified measurements, it is necessary to identify the exact time of intake after the shutdown and the actual physiochemical property of 132Te that affects the thyroid uptake of 132I.
Assuntos
Acidente Nuclear de Fukushima , Iodetos , Radioisótopos , Sódio , Tálio , Glândula Tireoide , Glândula Tireoide/diagnóstico por imagem , Radioisótopos do Iodo/análise , Telúrio/análise , Doses de RadiaçãoRESUMO
We experimentally obtained the responses of two personal dosemeters (PDs, D-shuttle and Dose-i) attached on five age-specific phantoms under rotational irradiation geometry, which simulated an environment that was radiologically affected by the 2011 Fukushima nuclear accident using of a 137Cs source. Although the PD responses showed an angular phase shift by the PD position on the phantoms, the angular dependence was small when the contamination was widely distributed. The PD responses decreased as much as ~10% with the increase in the phantoms' body size. Although there were ~17% variations in the PD/ADE (ambient dose equivalent) ratio depending on the different PDs, this variation was due to the fact that D-shuttle was calibrated with the inclusion of a safety margin. The PD/ADE ratios were similar to the effective dose to ADE ratios for corresponding age-specific phantoms. Our results suggest that these two PDs can provide reasonable estimates for age-dependent effective doses.
Assuntos
Acidente Nuclear de Fukushima , Doses de Radiação , Radioisótopos de Césio , Fatores EtáriosRESUMO
A new in-vivo counting system that functions as both a whole-body counter (WBC) and a lung counter (LC) was developed at the QST to enhance its dose assessment capability. This paper presents an overview of this system and the results of its performance tests. For use of the system as a WBC, three high purity germanium (HPGe) detectors installed in a 20-cm-thick iron shielding chamber are linearly arrayed over a subject lying on the bed, whereas two of the three HPGe detectors are placed over the subject's chest from side to side when using the system as an LC. The new in-vivo system was calibrated using three de-facto phantoms owned by the QST: an adult-male BOttle Manikin ABsorption (BOMAB) phantom, a Lawrence Livermore National Laboratory (LLNL) phantom and a Japan Atomic Energy Research Institute (JAERI) phantom. Monte Carlo simulations were also performed to determine an optimum location for the three detector array in the WBC mode and revealed that the peak efficiency for the BOMAB phantom (662 keV) was little varied as long as the middle detector was placed above the thorax and abdomen parts of the phantom. The calculated peak efficiencies agreed well with the observed peak efficiencies for photons with energies over 100 keV. For lung counting, a tentative Minimum Detectable Activity of 241Am was evaluated as 9.5 Bq for a counting time of 30 minutes, and a Japanese male subject with an average chest wall thinness (2.27 cm). The developed system is now ready for use.
Assuntos
Amerício , Germânio , Masculino , Humanos , Tórax , Contagem Corporal Total , Imagens de Fantasmas , Método de Monte CarloRESUMO
Japan's National Institutes for Quantum Science and Technology (QST) was designated as the core radiation emergency medical support center by the country's Nuclear Regulation Authority (NRA) in 2019. One of the main missions of the QST is to maintain and improve its dose assessment capability for radiation-exposed individuals. Toward the goal of effectively fulfilling this mission, a new facility-the Dose Assessment Building for Advanced Radiation Emergency Medicine-was constructed at the Chiba base of the QST in 2020. An integrated bioassay laboratory was installed in this facility for assessing subjects' internal doses, along with a new integrated in vivo counter. The bioassay capability of the new laboratory is currently expected to screen 5-10 persons simultaneously assuming internal contamination with actinides such as Pu, Am/Cm and U, although this is dependent on the specific contamination circumstances.
Assuntos
Elementos da Série Actinoide , Bioensaio , Laboratórios , Humanos , Elementos da Série Actinoide/análise , JapãoRESUMO
Accidental inhalation intake of plutonium isotopes and 241Am occurred at a Pu research facility in Japan in 2017, and the five workers involved in this accident were treated by the administration of Ca/Zn-diethylenetriaminepentaacetic acid (DTPA). For the worker who was most internally exposed, the therapy was continued over 1 y after the accident. Urinary samples collected before and after each administration were subject to bioassay to evaluate the efficacy of the dose reduction. This study performed numerical analyses using a biokinetic model dealing with 241Am-DTPA with reference to the European Coordinated Network on Radiation Dosimetry approach, which assumes that the complex of actinides and Ca/Zn-DTPA is generated in the designated compartments in the biokinetic model. The results of the model prediction well captured the trend of the observed urinary excretion in the long-term bioassay and would be useful to evaluate the efficacy of the Ca/Zn-DTPA administration for the worker involved in the accident.
Assuntos
Plutônio , Lesões por Radiação , Humanos , Quelantes , Amerício , Japão , Ácido Pentético , Plutônio/urina , Acidentes , Administração por InalaçãoRESUMO
Photon detectors utilised for direct thyroid measurements to determine the radioiodine content in the thyroid are normally calibrated using a phantom that mimics the human neck, including the thyroid. However, such measurements are necessarily subject to uncertainty because of the difference between the phantom and the real human subject and also the morphological differences among individuals. In this study, personal voxel phantoms were created from magnetic resonance images of the necks of 24 adult volunteers (15 males and 9 females), and numerical simulations using these phantoms were performed to examine the variation in a conversion factor (131I kBq in the thyroid per µSv h-1) for a conventional NaI(Tl) survey meter among the individuals and also to confirm the suitability of reference Japanese voxel phantoms as a calibration standard for such measurements. As a result, it was found that the conversion factor obtained from the reference Japanese male (female) phantom was 1.29 (1.18) times larger than the average conversion factor for the male (female) subjects, suggesting that the conversion factors of the reference Japanese adult male and female phantoms would generally overestimate the 131I thyroidal contents and that the thyroid volume would be one of the factors influencing the conversion factor. This study also revealed a wide difference in the thyroid volume among individuals, which would be of concern when performing specific dose assessments for heavily exposed persons.
Assuntos
Monitoramento de Radiação , Glândula Tireoide , Adulto , Humanos , Masculino , Feminino , Glândula Tireoide/diagnóstico por imagem , Radioisótopos do Iodo/análise , Incerteza , Monitoramento de Radiação/métodos , Imagens de Fantasmas , Método de Monte CarloRESUMO
It is a challenging task to establish a feasible and robust method for the population monitoring of individuals' thyroid exposure following an accidental intake of radioiodines in a nuclear emergency, because of the time restriction. The authors previously proposed a method for such monitoring to obtain as many reliable human data as possible and one of the components is simplified measurements by conventional NaI(Tl) survey meters that are intended to be used for the initial triage to identify significantly exposed individuals and get an overall picture of the exposure levels in a target population in a timely manner. This study determined screening levels (SLs) for a conventional NaI(Tl) survey meter (model TCS-172, Hitachi, Japan) using the conversion factor (131I kBq in the thyroid per µSv h-1) that were obtained from experiments and simulations with age-specific phantoms. The results demonstrated that the derived SLs for 100 mSv thyroid equivalent dose were as follows: 0.2 µSv h-1 (SL1) for the age group ≤ 5-y-olds, 0.5 µSv h-1 (SL2) for the 10- and 15-y-old age groups and 1.0 µSv h-1 (SL3) for adults. These SLs would be reasonably available within 1 week after the intake of 131I on the safe side.
Assuntos
Desastres , Monitoramento de Radiação , Adulto , Humanos , Glândula Tireoide , Radioisótopos do Iodo/análise , Monitoramento de Radiação/métodosRESUMO
ABSTRACT: It has been challenging to obtain reliable estimates of thyroid equivalent doses (TEDs) to residents involved in the 11 March 2011 Fukushima Daiichi Nuclear Power Plant (FDNPP) accident because of the shortage of direct human measurements associated with 131I, the largest contributor to the dose of concern. The present study attempted to perform the estimation of the TEDs by inhalation of 131I to residents from Namie-town, one of the most radiologically-affected municipalities, by means of the latest atmospheric transport and dispersion model (ATDM) simulations with the Worldwide version of System for Prediction of Environmental Emergency Dose Information (WSPEEDI) ver. 2, coupled with personal behavioral data containing the history of the whereabouts of individuals shortly after the accident. We analyzed 1,637 residents who underwent direct measurements with whole-body counters several months after the accident and provided their personal behavioral data. We divided the subjects into two groups based on whether the distances between their locations and the FDNPP were >20 km as of 15:00 on 12 March in relation to the timepoint of the hydrogen explosion at the Unit 1 Reactor building. As a result, the 90th percentile TEDs of the 1,249 prompt evacuees and 388 late evacuees were 3.9 mSv (adult)-6.8 mSv (10-y-old) and 24.1 mSv (adult)-35.6 mSv (5-y-old), respectively, excluding 16 persons whose TEDs exceeded 50 mSv. The 90th percentile (median) TEDs to 1-y-old children (not included in the subjects) for the prompt and late evacuation groups were 8.1 (1.0) mSv and 36.3 (19.7) mSv, respectively. Additionally, this study provided the evidence to support the view that the explosive event at the Unit 1 Reactor building on the afternoon of 12 March 2011 could have caused the critical group among Namie-town's residents, whereas the largest release event on 15 March gave relatively small doses to the residents because their exposure took place mostly at sites that were distant from the FDNPP. However, the present dose estimation has potentially large uncertainty at the individual level; further validations are thus necessary.
Assuntos
Acidente Nuclear de Fukushima , Monitoramento de Radiação , Adulto , Criança , Humanos , Radioisótopos do Iodo/análise , Japão , Doses de Radiação , Glândula TireoideRESUMO
The authors' previous study suggested that a simple standing-type whole-body counter called FASTSCAN (Canberra, Meriden, CT, USA), widely installed throughout Japan after the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident in March 2011, could be used for thyroid measurements in internal dose assessment after a future radiological incident accompanied by the release of 131I into the environment. The present study performed Monte-Carlo simulations using a computational human phantom with several patterns of body surface contamination and used the results to formulate a method for probabilistic analyses of 131I thyroid activity in persons with surface contamination. The major advantage of this method is that the upper limit of the thyroid activity can be determined from the relative frequency distribution without identifying where body surface contamination remains. Therefore, this method is especially effective for use in the early phase of a radiological incident when time and resources are limited, making it difficult to physically remove all body surface contamination for the purpose of gaining more accurate population-wide thyroid screening measurements. As a case study of the FDNPP accident, the proposed method was applied to the results of in vivo measurements for a male subject with body surface contamination. In comparing the probabilistic analyses before and after removal of the subject's contaminated work clothes, the uncertainty of the relative frequency distribution of 131I thyroid activity was reduced by their removal. Therefore, in terms of accurate estimates and avoidance of radiation exposure from their contaminated clothes, efforts to remove body surface contamination still should be made as much as possible in the chaotic situation of the early phase of a radiological incident.
Assuntos
Acidente Nuclear de Fukushima , Monitoramento de Radiação , Humanos , Radioisótopos do Iodo/análise , Japão , Masculino , Glândula Tireoide/diagnóstico por imagem , Contagem Corporal TotalRESUMO
ABSTRACT: More than 9 y have passed since the 2011 nuclear disaster in Fukushima Prefecture, Japan. During this period, much effort has been spent on the dose reconstruction for Fukushima residents; however, the estimation of the internal dose due to the potential intake of the short-lived radionuclides (mainly iodine-131) has been challenging because of the lack of direct human measurements at the early phase of the accident. Our previous study revealed that the residual cesium body contents observed in delayed whole-body counter (WBC) measurements of residents from Namie-town, one of the most affected municipalities, varied greatly with the timepoint of their evacuations on 12 March 2011 when the first explosive event occurred at the accident site; i.e., the late evacuees had much higher residual cesium body contents compared to the prompt evacuees. The present study thus aimed to clarify this finding by reproducing the exposure situation based on the evacuees' personal behavioral data in combination with the latest atmospheric transport and dispersion model (ATDM) simulation for 356 selected subjects in adult and 15-y (13-17 y) age groups. The results demonstrated that the ATDM simulation-based method could reasonably reproduce the subjects' exposure situation, supporting the previous finding. However, the residual cesium-137 body contents calculated by this method were only 10%-20% of those in the subjects' WBC measurements. This large discrepancy was considered to be caused by both the present method's underestimation and the overestimation of the subjects' early intake in the WBC measurements due to a conservative intake scenario not assuming potential additional intake. Additional studies are needed to further clarify the reasons for the discrepancy and to evaluate the magnitude of the inhalation dose in the accident.
Assuntos
Acidente Nuclear de Fukushima , Monitoramento de Radiação , Adulto , Radioisótopos de Césio/análise , Humanos , Japão , Centrais Nucleares , Monitoramento de Radiação/métodos , Contagem Corporal TotalRESUMO
ABSTRACT: It is very important to determine the precise internal thyroid doses of Fukushima residents involved in the 2011 Fukushima nuclear disaster, particularly for small children. This has been challenging due to the lack of direct human measurements to identify 131I, the biggest contributor to the thyroid doses. We previously used a dataset of late whole-body counter (WBC) measurements targeting 134Cs and 137Cs for the thyroid dose estimation in comparison with the intake ratios of 131I to 137Cs (or 134Cs) derived from thyroid and whole-body doses individually obtained from different subject groups, assuming simultaneous acute intake via inhalation. Herein, we applied the same method to the doses of residents in Iwaki city (located south of the Fukushima Daiichi Nuclear Power Plant) with a relatively high activity ratio (131I/137Cs) for the ground deposition density. Our analyses revealed that the intake ratio (131I/137Cs) for the Iwaki residents was 4.2-4.3, which is relatively consistent with the values obtained in other studies (average 3.0-5.0). No regional difference in the intake ratios from other areas was observed, but further studies are required to determine the accurate intake ratio in the early phase of the accident, in particular focusing on the reasonable interpretation of results of the late WBC measurements to evaluate the actual Cs intake.
Assuntos
Acidente Nuclear de Fukushima , Monitoramento de Radiação , Radioisótopos de Césio/análise , Criança , Humanos , Radioisótopos do Iodo/análise , Japão , Doses de Radiação , Monitoramento de Radiação/métodos , Glândula Tireoide , Contagem Corporal Total/métodosRESUMO
Estimating the internal thyroid dose received by residents involved in the 2011 Fukushima Daiichi Nuclear Power Plant (FDNPP) accident has been a challenging task because of the shortage of direct human measurements related to the largest contributing radioisotope to the dose, I. In a previous dose estimation, we used the results of whole-body counter (WBC) measurements targeting Cs and Cs, based on the assumption that these radioisotopes were incorporated at the same time as I in the early phase of the accident. The main purpose of this study was to clarify whether the trace of the early intake remained in the WBC measurements that were started several months after the accident. In the present work, WBC data of 1,639 persons from Namie town, one of the heavily contaminated municipalities, were analyzed together with their evacuation behavior data. The results demonstrated that the cesium detection rate in the WBC results was several times higher in the late evacuees [who evacuated outside the 20-km radius of the FDNPP at 3:00 p.m. (Japanese Local Time) on 12 March or later] compared to the prompt evacuees (who evacuated before 3:00 p.m. on 12 March). Among the adults, the cesium detection rates (and the 90th percentile values of the Cs intake) of the prompt and late evacuees were about 20% (5.4 × 10 Bq) and 60% (1.6 × 10 Bq), respectively. Approximately 20% of the individuals analyzed were categorized as late evacuees. These differences in cesium would be caused by exposure to the radioactive plume in the afternoon on 12 March, which was likely to influence the late evacuees. On the other hand, the intake on 15 March, when the largest release event occurred, was expected to be relatively small for Namie town's residents. In conclusion, the trace of the early intake remained in the WBC measurements, although this would not necessarily be true for all subjects. The results obtained from this study would provide useful information for the reconstruction of the early internal thyroid doses from radioiodine in the future.
Assuntos
Radioisótopos de Césio/análise , Planejamento em Desastres/estatística & dados numéricos , Acidente Nuclear de Fukushima , Exposição à Radiação/análise , Monitoramento de Radiação/métodos , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Doses de Radiação , Fatores de Tempo , Contagem Corporal TotalRESUMO
The dose reconstruction of populations potentially affected by the accident at the Fukushima Daiichi nuclear power plant in March 2011 is of great importance. However, it has been difficult to assess internal thyroid doses to Fukushima residents (mainly from their intake of I) due to the lack of direct measurements. For the residents, only about 1,300 data points related to I are available, and 1,080 of the data points were obtained from the screening campaign that was conducted by the Nuclear Emergency Response Local Headquarters at the end of March 2011 in Kawamata Town, Iwaki City, and Iitate Village. Here, we reassessed thyroid doses to 1,080 subjects aged ≤15 y old using new age-specific conversion factors to determine I thyroid contents from net signals of the devices used, with consideration for the possible uncertainty related to the measurements. The results demonstrated that thyroid equivalent doses to the subjects were <30 mSv (excluding outliers). We also demonstrate dose distributions of each age group from the above three municipalities and those of subjects from Minamisoma City and Fukushima City. One of the findings was that the I intake was similar among different age groups in each of the three municipalities. This was consistent with the assumption that ingestion was a dominant route of intake rather than inhalation. The range of thyroid doses to Iitate Village residents was similar to that to Iwaki City residents even though the I concentration in tap water was much higher in Iitate Village than Iwaki City. The range of thyroid doses to Minamisoma City residents was similar to that to Iitate Village and Iwaki City residents, and the range for Fukushima City residents was smallest among the five municipalities. Since the major route of intake has remained unclear, this paper presents the plausible upper and lower thyroid doses, between which the actual doses are thought to mostly exist, based on two intake scenarios: single inhalation and repeated ingestion. Further research is thus necessary to extract useful evidence from the individual evacuation behaviors for improving the present internal thyroid dose assessment.
Assuntos
Acidente Nuclear de Fukushima , Radioisótopos do Iodo/análise , Programas de Rastreamento/métodos , Exposição à Radiação/análise , Monitoramento de Radiação/métodos , Medição de Risco/métodos , Glândula Tireoide/efeitos da radiação , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Exposição por Inalação/análise , Masculino , Doses de Radiação , Inquéritos e Questionários , Contagem Corporal Total , Adulto JovemRESUMO
One of the authors (O.K.) stayed in the area located ~110 km south from the Fukushima Daiichi Nuclear Power Plant during the arrival of radioactive plumes released into the environment due to the accident in March 2011 in Japan. A previous study determined his 131I thyroid content using an NaI(Tl) spectrometer. The one remaining issue was to investigate the measurement error due to inevitable differences in the configuration (e.g. the thyroid shape and volume) between the physical phantom employed for calibration of the spectrometer and the real subject. In the present study, Monte Carlo simulations for the thyroid measurements were performed using the Monte Carlo N-Particle (MNCP) code to investigate discrepancies in peak efficiencies of the spectrometer between the personalised voxel phantom created from O.K.'s magnetic resonance images and the several typical/reference phantoms that exist. As a result, the peak efficiencies for the Oak Ridge Institute of Nuclear Studies (ORINS) phantom were found to be comparable to those for the reference voxel phantoms reproducing realistic human anatomy (the Adult Male phantom and the Japanese Male phantom). The peak efficiency for the personalised phantom, on the other hand, was fairly close to that of the other physical phantom (the Transfer phantom) actually used for the calibration of the spectrometer, suggesting that the 131I thyroid content determined for him in the previous study was sufficiently accurate. The discrepancies of peak efficiencies at the primal photon energy of 131I (365 keV) among the different phantoms were improved by extending the distance between the neck and the spectrometer; however, the appropriate measurement geometry in an actual situation will depend on the primary purpose of the measurements and should be determined accordingly.
Assuntos
Simulação por Computador , Iodetos/química , Radioisótopos do Iodo/análise , Método de Monte Carlo , Imagens de Fantasmas , Monitoramento de Radiação/instrumentação , Sódio/química , Tálio/química , Glândula Tireoide/metabolismo , Humanos , Centrais Nucleares , Monitoramento de Radiação/métodosRESUMO
As a response to the Tokyo Electric Power Company's Fukushima Daiichi nuclear power plant accident in 2011, seven TEPCO workers whose exposure doses were expected to be >250 mSv (a tentative dose limit stipulated by the Japanese central authority) attended Japan's National Institute for Radiological Sciences for additional internal dose measurements. The National Institute for Radiological Sciences examination revealed that these workers' internal doses came mainly from their intake of the radionuclide I during emergency operations. In this study, we performed numerical simulations based on individual volume-pixel (voxel) phantoms of six of the seven workers for a more sophisticated evaluation of their internal doses, taking into account the individual thyroid size and other specific parameters. The voxel phantoms were created from magnetic resonance imaging scan images. As a result, the individual thyroid volumes ranged from 6.5 to 28.2 cm and were considerably smaller than the reference value (~20 cm) adopted in the International Commission on Radiation Protection's dosimetric model for four of the six subjects. Compared to the original estimates of the thyroid absorbed dose, our preliminary evaluation revealed values that were increased by approximately 3-fold or decreased by 30% at maximum. A wide difference in the individual thyroid size would be one of the significant modifiers in the current dose estimation of subjects of the ongoing epidemiological study project. The present simulations also provided evidence that the direct thyroid measurements by the National Institute for Radiological Sciences to determine the workers' I thyroid contents were sufficiently accurate.
Assuntos
Radioisótopos do Iodo/análise , Centrais Nucleares , Exposição Ocupacional/análise , Imagens de Fantasmas , Monitoramento de Radiação/métodos , Poluentes Radioativos/análise , Glândula Tireoide/efeitos da radiação , Adulto , Feminino , Acidente Nuclear de Fukushima , Humanos , Japão , Masculino , Análise Numérica Assistida por Computador , Doses de Radiação , Proteção RadiológicaRESUMO
In the aftermath of the 2011 Fukushima nuclear disaster, a screening survey for thyroid internal exposure from intake of radioiodine was performed on 1080 children using handheld NaI(Tl) survey meters. This article presents the design and results of a practical exercise conducted to develop the skills of personnel who would be potentially engaged in such a survey. Participants of this exercise were asked to measure manikin heads in which point sources were installed under normal (~0.05 µSv h-1) and elevated (~0.5 µSv h-1) background conditions. The results demonstrated that the measurements were less dependent on the background radiation level, and the deviation of net signals obtained by the participants were within 10-20% for dose rates above 0.2 µSv h-1. This result suggests that dose rates can be reliably obtained above a provisional operational intervention level for the device, 0.5 µSv h-1 under a real nuclear accident situation.
Assuntos
Radioisótopos do Iodo/análise , Centrais Nucleares , Monitoramento de Radiação/métodos , Glândula Tireoide/efeitos da radiação , Humanos , Radioisótopos do Iodo/efeitos adversos , Doses de Radiação , Liberação Nociva de Radioativos , Medição de Risco , Inquéritos e QuestionáriosRESUMO
Whole-body counter measurements of residents of Fukushima Prefecture have been extensively performed after the Fukushima Dai-ichi Nuclear Power Plant accident in March 2011. These measurements have demonstrated that the levels of internal contamination with radioactive cesium (Cs and Cs) in the residents are very low. This article provides an overview of and lessons learned from these whole-body counter measurements with emphasis on the technical problems encountered, and it discusses the effective use of whole-body counters for assessing the internal thyroid doses of individuals when direct measurements of I in the thyroid are difficult or impossible to implement for the total affected population in a short time after a nuclear reactor accident. The application of this dose reconstruction method requires determining the intake ratio of I to cesium isotopes at appropriate times and considers the short biological half-lives of cesium isotopes, in particular for children.
Assuntos
Acidente Nuclear de Fukushima , Radioisótopos do Iodo/análise , Imagens de Fantasmas , Vigilância da População , Monitoramento de Radiação/métodos , Glândula Tireoide/efeitos da radiação , Contagem Corporal Total/métodos , Adulto , Criança , Feminino , Humanos , Masculino , Doses de RadiaçãoRESUMO
The Tokyo Electric Power Company's Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident exposed members of the public to radiation. This study analyses the relation between personal behavior data obtained from 112 out of 174 subjects who underwent whole-body measurements by the National Institute of Radiological Sciences (NIRS) during the period from 27 June to 28 July 2011 and their committed effective doses (CEDs) from Cs and Cs. The whereabouts of the 112 persons living in municipalities near the FDNPP (mainly, Namie town) on several days in March 2011 are graphed on maps. It was confirmed that most subjects started evacuation promptly and had left the 20-km-radius of the FDNPP by the end of 12 March. The individual CEDs were poorly correlated with the person's distances from the FDNPP at any day in March. Meanwhile, the percentage of persons remaining within the 20-km radius of the FDNPP was 100% at 16:00 on 12 March and 42.9% at 0:00 on 15 March for those with CEDs > 0.1 mSv, whereas the corresponding values were much lower for those with CEDs ≤ 0.1 mSv. This suggests that the time of evacuation would be one of the crucial factors for the early intake; however, more personal behavior data are needed to be analyzed to clarify the relevance to the individual internal dose.