Novel 3D polycaprolactone scaffold for ridge preservation--a pilot randomised controlled clinical trial.

OBJECTIVES: This pilot randomised controlled clinical trial aimed to evaluate the feasibility and effectiveness of using a polycaprolactone (PCL) scaffold in fresh extraction sockets for ridge preservation. The hypothesis was that the insertion of a 3D bioresorbable PCL scaffold in fresh extraction sockets allowed for normal bone healing and better maintenance of ridge dimensions after 6 months as compared to extraction sockets without the scaffold. MATERIAL AND METHODS: Thirteen patients were randomised to either the test group (N = 6) where a PCL scaffold was inserted in the tooth socket after extraction or the control group (N = 7) where no space filler was used. Alveolar ridge height and width measurements were made at baseline and 6 months post-extraction, for the evaluation of bone resorption. At 6 months, a core of bone was trephined out from the healed ridge for microcomputed tomographic (micro CT) and histological analyses, immediately before Stage I dental implant surgery. Stage II dental implant surgery was performed 4-6 months later. RESULTS: There was less vertical ridge resorption in the test group compared to the control group, and the difference was statistically significant in the mesio-buccal aspect (P = 0.008). Micro CT and histological observations showed mainly mineralised bone formation in both groups, except for one specimen in the test group. CONCLUSIONS: The insertion of a 3D bioresorbable PCL scaffold in fresh extraction sockets allowed for normal bone healing, and there was better maintenance of ridge height after 6 months as compared to extraction sockets without the scaffold.

Immediate repair of transected inferior alveolar nerves in sagittal split osteotomies.

BACKGROUND: Injury to the inferior alveolar nerve (IAN) in orthognathic surgery is a well-documented complication with the incidence of IAN transection in sagittal split osteotomies (SSOs) ranging from 1.3% to 7.0%. PATIENTS AND METHODS: We describe our clinical experience with 3 cases of immediate microneural repair of IANs transected during SSO. RESULTS: Three cases of IAN transection (2 Sunderland degree V injuries, and 1 degree VI injury) that occurred during SSO were microsurgically repaired immediately by a trained microsurgeon. The other orthognathic surgery sites were positioned and fixed before the nerve repair commenced, and fixation of the nerve injury site was completed by the microsurgeon after nerve repair. All 3 patients were followed for at least 1 year with neurosensory testing, and showed recovery to mild or no sensory impairment. None had functional problems such as drooling, lip-biting, or speech difficulties at 1 year after surgery. CONCLUSION: Immediate nerve repair for transected IANs during SSO may be a feasible option, but requires the availability of a microsurgeon, instrumentation, and operating-room time.