Iridium-catalyzed selective arylation of B(6)-H of 3-aryl-o-carboranes with arylboronic acid via direct B-H activation.

This work discloses an iridium-catalyzed selective arylation of B(6)-H of 3-Ar-o-carboranes with arylboronic acid via direct B-H activation for the first time. A series of unsymmetric and symmetric 3,6-diaryl-o-carboranes decorated with diverse active groups have been synthesized with moderate to excellent yields under mild conditions. This work offers an efficient approach for selective arylation of B(6)-H with arylboronic acid and has important value for selective functionalization of o-carboranes.

Iridium-catalyzed selective amination of B(4)-H for the synthesis of o-carborane-fused indolines.

An iridium-catalyzed selective amination of B(4)-H via dehydrogenative cross-coupling of B-H/N-H bonds for the synthesis of o-carborane-fused indolines has been developed for the first time. Various types of unprecedented o-carborane-fused indolines have been synthesized, which would be potential candidates for applications in drug discovery, pharmaceutical chemistry and functional materials. This work offers a valuable reference for the designing and synthesis of o-carborane-fused heterocycles.