Worlds apart or two sides of the same coin? Attitudes, meanings, and motives of potential oocyte and sperm donors in Austria.

PURPOSE: Gamete donors and recipients of such donations have been explored by previous studies, which mostly focus on post-donation scenarios. Our study analyses the general willingness to donate oocytes or sperm and focuses on differences between potential female and male donors in attitudes, meanings, and motives in a pre-donation setting. METHODS: An electronic survey (n = 555 students) was used in this anonymous observational study. To enable comparisons between men and women regarding their attitudes, meanings, and motives and their willingness to donate gametes, we designed two separate questionnaires. RESULTS: The sample was divided into three groups based on the willingness to donate: potential donors (n = 133; women: 48.1%, men: 51.9%); doubtful donors (n = 207; women: 75.8%, men: 24.2%); and non-donors (n = 215; women: 68.3%, men: 31.7%). The group of potential male donors (39.2%) was significantly larger than the group of potential female donors (16.9%). Significant differences regarding altruism, the meaning of one's self-worth, and passing on the own genes were found between doubtful and potential donors. Potential donors attached less value to altruism but more value to the enhancement of one's self-worth and passing on one's genes than doubtful donors. The motive of passing on one's genes and altruistic motives were more important to men than to women. CONCLUSION: This study helps to create a better understanding of potential donors in the existing donation framework and supports the evaluation of the given regimes in the context of designing an improved framework.

Legislation of direct-to-consumer genetic testing in Europe: a fragmented regulatory landscape.

Despite the increasing availability of direct-to-consumer (DTC) genetic testing, it is currently unclear how such services are regulated in Europe, due to the lack of EU or national legislation specifically addressing this issue. In this article, we provide an overview of laws that could potentially impact the regulation of DTC genetic testing in 26 European countries, namely Austria, Belgium, Cyprus, the Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, the Netherlands and the United Kingdom. Emphasis is placed on provisions relating to medical supervision, genetic counselling and informed consent. Our results indicate that currently there is a wide spectrum of laws regarding genetic testing in Europe. There are countries (e.g. France and Germany) which essentially ban DTC genetic testing, while in others (e.g. Luxembourg and Poland) DTC genetic testing may only be restricted by general laws, usually regarding health care services and patients' rights.

Rb/Sr isotopic and compositional retentivity of muscovite during deformation.

Permian metapegmatite muscovite from the Upper-Austroalpine Matsch Unit in Southern Tyrol (Italy) was investigated regarding its Rb/Sr and compositional retentivity during Cretaceous Upper-greenschist facies deformation. The data imply that microstructurally relic Permian magmatic muscovite largely maintained its major and trace element compositions during deformation, whereas the Rb/Sr geochronometer is strongly affected by a net loss of Sr. Lower Sr concentrations of muscovite correlate with higher 87Rb/86Sr and 87Sr/86Sr ratios. In most samples, the muscovite grain size- and magnetic-fractions with the lowest 87Rb/86Sr and 87Sr/86Sr ratios preserve a Permo-Triassic muscovite-whole rock Rb/Sr apparent age interpreted as to reflect formation during or cooling after pegmatite emplacement. Contrastingly, muscovite fractions with higher 87Rb/86Sr and 87Sr/86Sr ratios are arranged along a roughly linear array with a positive correlation of the 87Rb/86Sr and 87Sr/86Sr ratios in the 87Rb/86Sr vs 87Sr/86Sr space. They yield successively lower muscovite-whole rock Rb/Sr apparent ages. We explain the variations in the Rb/Sr isotopic character of microstructurally relic muscovite by a, presumably deformation-related, loss of Sr during the Cretaceous event. Contemporaneously, only very limited amounts of isotopically different Sr from the matrix reservoir might possibly have entered the muscovite. Consequently, the Rb/Sr of the relic muscovite is affected by a net loss of Sr. The results imply that at temperatures of < 500 °C, deformation is supposed to be the predominant factor in controlling the Rb/Sr geochronometer of relic muscovite, by significantly reducing the characteristic length scale for volume diffusion. However, variations of the major and trace element compositions within Permian relic muscovite are interpreted to rather reflect primary compositional instead of deformation-related variations.

New geochronological constraints on the thermal and exhumation history of the Lesser and Higher Himalayan Crystalline Units in the Kullu-Kinnaur area of Himachal Pradesh (India).

New geochronological, petrological and structural data from the Beas-Sutlej area of Himachal Pradesh (India) are used to reconstruct the tectonothermal and exhumation history of this part of the Himalayan orogen. Sm-Nd garnet ages at 40.5 ± 1.3 Ma obtained on a pegmatoid from the inverse metamorphic High Himalayan Crystalline (HHC) in the Malana-Parbati area probably mark local melting during initial decompression. Ongoing exhumation in ductilely deformed leuco-gneiss is constrained by Sm-Nd garnet ages at 29 ± 1 Ma and white mica Rb-Sr ages around 24-20 Ma, while Bt Rb-Sr ages indicate a drop of regional metamorphic temperatures below 300 °C between 15 and 12 Ma. The deep Sutlej gorge exposes medium-grade paragneisses and Proterozoic orthogneisses of the Lesser Himalayan Crystalline (LHC), overthrust by the HHC along the Main Central Thrust (MCT). Mica cooling ages in the HHC are in the range of 14-11 Ma. Above the extruded wedge of the HHC, the Leo Pargil leucogranite and associated dykes intrude the Haimanta Unit (HU) below the weakly metamorphic Palaeo-Mesozoic sediments of the Tethyan Himalayas (TH). The Leo Pargil leucogranite yielded a mean Sm-Nd garnet age of 19 ± 1 Ma and Rb-Sr muscovite and biotite cooling ages between 16.4 and 11.6 Ma. Marked young extrusion of LHC units resulted in differentiated exhumation/cooling of more frontal parts of the orogen. Very young ductile deformation of LHC gneisses near Wangtu is constrained by late-kinematic pegmatite intrusions crosscutting the main mylonitic foliation. Sm-Nd garnet and Rb-Sr muscovite ages of these pegmatites range between 7.9 ± 0.9 and 5.5 ± 0.1 Ma. Published apatite FT ages down to 0.6 Ma also document accelerated diachronous sub-recent exhumation of different parts of the orogen. Together with geochronological data from the literature, the new results demonstrate that the HHC and the HU were deformed by shortening and crustal thickening during the Eohimalayan phase (Late Eocene-Oligocene), followed by a strong thermal overprint and intrusions of granitoids during the Neohimalayan Phase (Early to Middle Miocene). The LHC experienced amphibolite facies metamorphic conditions in the Late Miocene prior to extrusion between the HHC and the very low-grade Lesser Himalayan sediments. In conjunction with climate changes, young tectonic activity in this central part of the Himalayan orogen may have strongly influenced fluvial incision and erosion, and therefore, contributed to the accelerated uplift, as indicated by extensive accumulation of Late Miocene to Early Pleistocene fluviatile-lacustrine sediments in the Zanda basin, the Transhimalayan headwaters of the Sutlej, in Western Tibet.

Origin and age of the Eisenkappel gabbro to granite suite (Carinthia, SE Austrian Alps).

The northern part of the Karawanken plutonic belt is a gabbro-granite complex located just north of the Periadriatic lineament near the Slovenian-Austrian border. Petrographic and geochemical studies of the Eisenkappel intrusive complex indicate that this multiphase plutonic suite developed by a combination of crystal accumulation, fractional crystallization and assimilation processes, magma mixing and mingling. The mafic rocks are alkaline and have within-plate geochemical characteristics, indicating anorogenic magmatism in an extensional setting and derivation from an enriched mantle source. The mafic melts triggered partial melting of the crust and the formation of granite. The granitic rocks are alkalic, metaluminous and have the high Fe/Fe + Mg characteristics of within-plate plutons. Temperature and pressure conditions, derived from amphibole-plagioclase and different amphibole thermobarometers, suggest that the analysed Eisenkappel gabbros crystallized at around 1000 ± 20 °C and 380-470 MPa, whereas the granitic rock crystallized at T ≤ 800 ± 20 °C and ≤ 350 MPa. Mineral-whole rock Sm-Nd analyses of two cumulate gabbros yielded 249 ± 8.4 Ma and 250 ± 26 Ma (εNd: + 3.6), garnet-whole rock Sm-Nd analyses of two silicic samples yielded well-constrained ages of 238.4 ± 1.9 Ma and 242.1 ± 2.1 Ma (εNd: - 2.6).