Fully implanted adaptive deep brain stimulation in freely moving essential tremor patients.

OBJECTIVE: Deep brain stimulation (DBS) is a safe and established treatment for essential tremor (ET) and several other movement disorders. One approach to improving DBS therapy is adaptive DBS (aDBS), in which stimulation parameters are modulated in real time based on biofeedback from either external or implanted sensors. Previously tested systems have fallen short of translational applicability due to the requirement for patients to continuously wear the necessary sensors or processing devices, as well as privacy and security concerns. APPROACH: We designed and implemented a translation-ready training data collection system for fully implanted aDBS. Two patients chronically implanted with electrocorticography strips over the hand portion of M1 and DBS probes in the ipsilateral ventral intermediate nucleus of the thalamus for treatment of ET were recruited for this study. Training was conducted using a translation-ready distributed training procedure, allowing a substantially higher degree of control over data collection than previous works. A linear classifier was trained using this system, biased towards activating stimulation in accordance with clinical considerations. MAIN RESULTS: The clinically relevant average false negative rate, defined as fraction of time during which stimulation dropped below [Formula: see text] clinical levels during movement epochs, was 0.036. Tremor suppression, calculated through analysis of gyroscope data, was 33.2% more effective on average with aDBS than with continuous DBS. During a period of free movement with aDBS, one patient reported a slight paresthesia; patients noticed no difference in treatment efficacy between systems. SIGNIFICANCE: Here is presented the first translation-ready training procedure for a fully embedded aDBS control system for MDs and one of the first examples of such a system in ET, adding to the consensus that fully implanted aDBS systems are sufficiently mature for broader deployment in treatment of movement disorders.

Magnetic diagnostic suite of the C-2W field-reversed configuration experiment.

A fundamental component of any magnetically confined fusion experiment is a firm understanding of the magnetic field. The increased complexity of the C-2W machine warrants an equally enhanced diagnostic capability. C-2W is outfitted with over 700 magnetic field probes of various types. They are both internal and external to the vacuum vessel. Inside, a linear array of innovative in-vacuum annular flux loop/B-dot combination probes provide information about plasma shape, size, pressure, energy, temperature, and trapped flux when coupled with established theoretical interpretations. A linear array of B-dot probes complement the azimuthally averaged measurements. A Mirnov array of 64 3D probes, with both low and high frequency resolution, detail plasma motion and MHD modal content via singular value decomposition analysis. Internal Rogowski probes measure axial currents flowing in the plasma jet. Outside, every feed-through for an internal probe has an external axial field probe. There are many external loops that measure the plasma formation dynamics and the total external magnetic flux. The external measurements are primarily used to characterize eddy currents in the vessel during a plasma shot. Details of these probes and the data derived from their signals are described.

Characterization and calibration of the Thomson scattering diagnostic suite for the C-2W field-reversed configuration experiment.

The new C-2W Thomson scattering (TS) diagnostic consists of two individual subsystems for monitoring electron temperature (Te) and density (ne): one system in the central region is currently operational, and the second system is being commissioned to monitor the open field line region. Validating the performance of the TS's custom designed system components and unique calibration of the detection system and diagnostic as a whole is crucial to obtaining high precision Te and ne profiles of C-2W's plasma. The major components include a diode-pumped Nd:YAG laser which produces 35 pulses at up to 20 kHz, uniquely designed collection lenses with a fast numerical aperture, and uniquely designed polychromators with filters sets to optimize a Te ranging from 10 eV to 2 keV. This paper describes the design principles and techniques used to characterize the main components of the TS diagnostic on C-2W, as well as the results of Rayleigh scattering calibrations performed for the whole system response.

Integrated diagnostic and data analysis system of the C-2W advanced beam-driven field-reversed configuration plasma experiment.

The new C-2W experiment (also called Norman) at TAE Technologies, Inc. studies the evolution of field-reversed configuration (FRC) plasmas sustained by neutral beam injection. Data on the FRC plasma performance are provided by a comprehensive suite of diagnostics that includes over 700 magnetic sensors, four interferometer systems, multi-chord far-infrared polarimetry, two Thomson scattering systems, ten types of spectroscopic measurements, multiple fast imaging cameras with selectable atomic line filters, bolometry, reflectometry, neutral particle analyzers, and fusion product detectors. Most of these diagnostic systems are newly built using experience and data from the preceding C-2U experiment to guide the design process. A variety of commercial and custom acquisition electronics collect over 4000 raw signals from the C-2W diagnostics. These data are processed into physics results using a large-scale database of diagnostics metadata and analysis software, both built using open-source software tools.

Particle and heat flux diagnostics on the C-2W divertor electrodes.

A suite of diagnostics was developed to measure particle and heat fluxes arriving at the divertor electrodes of the C-2W experiment at TAE Technologies. The divertor electrodes consist of 4 concentric rings, each equipped with a bolometer, electrostatic energy analyzer, and thermocouple mounted at two opposing azimuthal locations. These probes provide measurements of the power flux to the divertor electrodes as well as measurements of the ion current density, ion energy distribution, and total energy deposition. The thermocouples also provide calibration points for inferring the heat deposition profile via thermographic imaging of the electrodes with a fast infrared camera. The combined measurements enable the calculation of the energy lost per escaping electron/ion pair, which is an important metric for understanding electron heat transport in the open field lines that surround the field-reversed configuration plasma in C-2W.

Thomson scattering systems on C-2W field-reversed configuration plasma experiment.

TAE Technologies' newly constructed C-2W experiment aims to improve the ion and electron temperatures in a sustained field-reversed configuration plasma. A suite of Thomson scattering systems has been designed and constructed for electron temperature and density profile measurements. The systems are designed for electron densities of 1 × 1012 cm-3 to 2 × 1014 cm-3 and temperature ranges from 10 eV to 2 keV. The central system will provide profile measurements of Te and ne at 16 radial locations from r = -9 cm to r = 64 cm with a temporal resolution of 20 kHz for 4 pulses or 1 kHz for 30 pulses. The jet system will provide profile measurements of Te and ne at 5 radial locations in the open field region from r = -5 cm to r = 15 cm with a temporal resolution of 100 Hz. The central system and its components have been characterized, calibrated, installed, and commissioned. A maximum-likelihood algorithm has been applied for data processing and analysis.

Calibration and applications of visible imaging cameras on the C-2U advanced beam-driven field-reversed configuration device.

Two filtered, fast-imaging instruments, with radial and axial views, respectively, were used on the C-2U device to visualize line emission from impurities and hydrogenic neutrals. Novel calibration techniques needed to be developed for these instruments because the accelerated pace of C-2U operations precluded access to the interior of the vacuum vessel, targets used in typical calibration methods were not available, and in order to account for effects which have not been sufficiently addressed in the literature. Spatial calibration involved optimizing parameters in a generic camera model: ex situ using a checkerboard target and in situ using the vacuum vessel port geometry. Radiometric calibration was performed ex situ in three stages. First, the camera relative response function was mapped using an algorithm developed for high dynamic-range imaging. Second, the non-uniformity of the optical system was measured using a large LCD monitor with a characterized angular emission pattern. Finally, the absolute photon efficiency of each interference filter was determined using a calibrated uniform radiance source while also accounting for reduction in the filter transmission for off-normal rays. Periodically during the run campaign, line emission from neutral beams fired into a gas target was used as an in situ reference to check for degradation of viewport transmission. One application using calibrated camera data was tomographic reconstruction of passive impurity emission, which provided a sanity check to the excluded-flux radius inferred from wall-mounted magnetic sensors.

Design of a custom insertable probe platform for measurements of C-2W inner divertor plasma parameters.

A custom motor controlled probe system has been designed to make spatially resolved measurements of temperature, density, flow, and plasma potential in the C-2W inner divertors. Measurements in the inner divertors, which have a 1.7 m radius and are located on either end of the confinement vessel, are critical in order to gauge exactly how local settings affect the plasma conditions, confinement, and stability in the field-reversed configuration core. The inner Divertor Insertable Probe Platform (iDIPP) system consists of a custom motor controlled linear rack and pinion transporter that has a 1.9 m travel length in order to reach the center of the divertor. Mounted to the end of the transporter is a 1 m long segmented probe shaft made of individually floating stainless steel rings to prevent shorting out the electrode plates, which are biased up to 5 kV/m. A variety of interchangeable probe tips, including a triple Langmuir probe, a baffled probe, and a Gundestrup probe, can plug into the end of the probe shaft. Custom UHV coiled cabling comprised of 9 shielded conductors expands/retracts with the motion of the transporter in/out of the divertor. The physics motivating plasma parameter measurements in the inner divertors and the details of the design of the iDIPP system will be discussed.

Jet outflow and open field line measurements on the C-2W advanced beam-driven field-reversed configuration plasma experiment.

Accurate operation and high performance of the open field line plasma surrounding the field reversed configuration is crucial to achieving the goals of successful temperature ramp up and confinement improvement on C-2W. Knowledge and control of the open field line plasma requires extensive diagnostic efforts. A suite of diagnostics, which consists of microwave interferometry, dispersive spectroscopy, and spatial heterodyne spectroscopy, is being developed to measure electron density, ion temperature, and particle outflow velocity at various locations along the open magnetic field lines. A detailed overview of these diagnostics is presented.

Development of a Z eff diagnostic using visible and near-infrared bremsstrahlung light for the C-2W field-reversed configuration plasma.

In C-2W, an elevated impurity concentration can lead to significant degradation of plasma performance and energy losses through radiation. To gauge plasma contamination from impurities, the effective ion charge (Z eff) can be determined from measurements of bremsstrahlung continuum radiation over a small spectral range free from line radiation. To this end, a diagnostic system including visible and near-infrared bremsstrahlung detectors was deployed in C-2W to measure time-dependent radial distributions of Z eff. The system is complemented by an array of survey spectrometers which enable full-range spectroscopic measurements of impurity emission lines from the vacuum ultraviolet to the near infrared, providing a good picture of the plasma composition. Here, the design scheme for this integrated diagnostic system is presented and discussed.

The upgrade of the Thomson scattering system for measurement on the C-2/C-2U devices.

The C-2/C-2U Thomson scattering system has been substantially upgraded during the latter phase of C-2/C-2U program. A Rayleigh channel has been added to each of the three polychromators of the C-2/C-2U Thomson scattering system. Onsite spectral calibration has been applied to avoid the issue of different channel responses at different spots on the photomultiplier tube surface. With the added Rayleigh channel, the absolute intensity response of the system is calibrated with Rayleigh scattering in argon gas from 0.1 to 4 Torr, where the Rayleigh scattering signal is comparable to the Thomson scattering signal at electron densities from 1 × 1013 to 4 × 1014 cm-3. A new signal processing algorithm, using a maximum likelihood method and including detailed analysis of different noise contributions within the system, has been developed to obtain electron temperature and density profiles. The system setup, spectral and intensity calibration procedure and its outcome, data analysis, and the results of electron temperature/density profile measurements will be presented.

End loss analyzer system for measurements of plasma flux at the C-2U divertor electrode.

An end loss analyzer system consisting of electrostatic, gridded retarding-potential analyzers and pyroelectric crystal bolometers was developed to characterize the plasma loss along open field lines to the divertors of C-2U. The system measures the current and energy distribution of escaping ions as well as the total power flux to enable calculation of the energy lost per escaping electron/ion pair. Special care was taken in the construction of the analyzer elements so that they can be directly mounted to the divertor electrode. An attenuation plate at the entrance to the gridded retarding-potential analyzer reduces plasma density by a factor of 60 to prevent space charge limitations inside the device, without sacrificing its angular acceptance of ions. In addition, all of the electronics for the measurement are isolated from ground so that they can float to the bias potential of the electrode, 2 kV below ground.

Jet outflow and open field line measurements on the C-2U advanced beam-driven field-reversed configuration plasma experiment.

Knowledge and control of the axial outflow of plasma particles and energy along open-magnetic-field lines are of crucial importance to the stability and longevity of the advanced beam-driven field-reversed configuration plasma. An overview of the diagnostic methods used to perform measurements on the open field line plasma on C-2U is presented, including passive Doppler impurity spectroscopy, microwave interferometry, and triple Langmuir probe measurements. Results of these measurements provide the jet ion temperature and axial velocity, electron density, and high frequency density fluctuations.

Diagnostic suite of the C-2U advanced beam-driven field-reversed configuration plasma experiment.

The C-2U experiment at Tri Alpha Energy studies the evolution of field-reversed configuration (FRC) plasmas sustained by neutral beam injection. Data on the FRC plasma performance are provided by a comprehensive suite of diagnostics that includes magnetic sensors, interferometry, Thomson scattering, spectroscopy, bolometry, reflectometry, neutral particle analyzers, and fusion product detectors. While many of these diagnostic systems were inherited from the preceding experiment C-2, C-2U has a variety of new and upgraded diagnostic systems: multi-chord far-infrared polarimetry, multiple fast imaging cameras with selectable atomic line filters, proton detector arrays, and 100 channel bolometer units capable of observing multiple regions of the spectrum simultaneously. In addition, extensive ongoing work focuses on advanced methods of measuring separatrix shape and plasma current profile that will facilitate equilibrium reconstruction and active control of the FRC plasma.

Enhanced magnetic field probe array for improved excluded flux calculations on the C-2U advanced beam-driven field-reversed configuration plasma experiment.

External flux conserving coils were installed onto the exterior of the C-2U [M. W. Binderbauer et al., Phys. Plasmas 22, 056110 (2015)] confinement vessel to increase the flux confinement time of the system. The 0.5 in. stainless steel vessel wall has a skin time of ∼5 ms. The addition of the external copper coils effectively increases this time to ∼7 ms. This led to better-confined/longer-lived field-reversed configuration (FRC) plasmas. The fringing fields generated by the external coils have the side effect of rendering external field measurements invalid. Such measurements were key to the previous method of excluded flux calculation [M. C. Thompson et al., Rev. Sci. Instrum. 83, 10D709 (2012)]. A new array of B-dot probes and Rogowski coils were installed to better determine the amount of flux leaked out of the system and ultimately provide a more robust measurement of plasma parameters related to pressure balance including the excluded flux radius. The B-dot probes are surface mountable chip inductors with inductance of 33 µH capable of measuring the DC magnetic field and transient field, due to resistive current decay in the wall/coils, when coupled with active integrators. The Rogowski coils measure the total change in current in each external coil (150 A/2 ms). Currents were also actively driven in the external coils. This renders the assumption of total flux conservation invalid which further complicates the analysis process. The ultimate solution to these issues and the record breaking resultant FRC lifetimes will be presented.

High sensitivity far infrared laser diagnostics for the C-2U advanced beam-driven field-reversed configuration plasmas.

A high sensitivity multi-channel far infrared laser diagnostics with switchable interferometry and polarimetry operation modes for the advanced neutral beam-driven C-2U field-reversed configuration (FRC) plasmas is described. The interferometer achieved superior resolution of 1 × 1016 m-2 at >1.5 MHz bandwidth, illustrated by measurement of small amplitude high frequency fluctuations. The polarimetry achieved 0.04° instrument resolution and 0.1° actual resolution in the challenging high density gradient environment with >0.5 MHz bandwidth, making it suitable for weak internal magnetic field measurements in the C-2U plasmas, where the maximum Faraday rotation angle is less than 1°. The polarimetry resolution data is analyzed, and high resolution Faraday rotation data in C-2U is presented together with direct evidences of field reversal in FRC magnetic structure obtained for the first time by a non-perturbative method.

Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein.

We report the crystal structure of a novel 60-subunit dodecahedral cage that results from self-assembly of a re-engineered version of a natural protein (PduA) from the Pdu microcompartment shell. Biophysical data illustrate the dependence of assembly on solution conditions, opening up new applications in microcompartment studies and nanotechnology.

Utilization of Cavity Vortex To Delay the Wetting Transition in One-Dimensional Structured Microchannels.

Frictional resistance across rough surfaces depends on the existence of slip on the liquid-gas interface; therefore, prolonging the existence of liquid-gas interface becomes relevant. In this work, we explore manipulation of the cavity shape in order to delay the wetting transition. We propose that liquid-driven vortices generated in the air cavity dissipate sufficient energy to delay the Cassie-Wenzel transition. Toward this, we fabricated cavities on the side walls of a polydimethylsiloxane-based microchannel for easy visualization and analysis of the dynamics of the liquid-gas interface. Two distinct flow regimes are identified in the experimental envelope. In the first regime, the liquid-gas interface is found to be protruding into the flow field, thus increasing the pressure drop at low Reynolds number. In the second regime, flow rate and geometry-based wetting transitions are established at moderate to high Reynolds numbers. We then investigate the effect of different cavity shapes (square, trapezoidal, and U-shape) in delaying the wetting transition by manipulating liquid-driven vortices. Out of the shapes considered in this study, trapezoidal cavities perform better than cavities with vertical walls in delaying the wetting transition due to geometrical squeezing of vortices toward the liquid-gas interface. Numerical simulations corroborate the experimental findings in that cavities with inclined walls exert more force on the liquid-gas interface, thus delaying their wetting transition. The proposed method being passive in nature appears more attractive than previous active methods.

Overview of C-2 field-reversed configuration experiment plasma diagnostics.

A comprehensive diagnostic suite for field-reversed configuration (FRC) plasmas has been developed and installed on the C-2 device at Tri Alpha Energy to investigate the dynamics of FRC formation as well as to understand key FRC physics properties, e.g., confinement and stability, throughout a discharge. C-2 is a unique, large compact-toroid merging device that produces FRC plasmas partially sustained for up to ∼5 ms by neutral-beam (NB) injection and end-on plasma-guns for stability control. Fundamental C-2 FRC properties are diagnosed by magnetics, interferometry, Thomson scattering, spectroscopy, bolometry, reflectometry, and NB-related fast-ion/neutral diagnostics. These diagnostics (totaling >50 systems) are essential to support the primary goal of developing a deep understanding of NB-driven FRCs.

The all-ceramic, inlay supported fixed partial denture. Part 4. Fracture surface analyses of an experimental model, all-ceramic, inlay supported fixed partial denture.

BACKGROUND: In the previous three papers, the authors sought to conduct a thorough analysis of the feasibility for the use of zirconia in inlay supported, fixed partial dentures via finite element analysis (FEA). Correlating the response of the numerical model against the experimental model has never been satisfactorily performed for an anatomically accurate ceramic bridge; such validation is crucial if the results from the FEA are to be confidently relied upon. Part 4 of this series is a detailed fractographic analysis of the zirconia bridge that was the model for the experimental validation, performed in order to confirm the fracture origin/s and fracture trajectory as predicted from the FEA. METHODS: Established fractographic techniques involving optical examination followed by examination with scanning electron microscopy were conducted. The porous, granular surface of zirconia (both partially and fully sintered) does not lend itself to easy surface analysis but the classic fractographic signs (hackle lines, wake hackle lines and compression curl) are present. Use of linear fracture elastic mechanics allowed the calculation of theoretical critical flaw size and a comparison to two defects or inclusions found at the primary origin of fracture. RESULTS: Excellent agreement between the fracture sites and paths of travel as predicted in the numerical analysis exist with fractographic analysis. Furthermore, the calculated critical flaw size of 30 µm to 40 µm equates very well with defects seen at the general vicinity of the primary fracture origin and the general observed size of critical flaws in machined ceramics which range between 20 µm to 50 µm, thus providing further confirmation. CONCLUSIONS: The fractographic analysis detailed in this study provides validation of the 'zones of failure' as predicted in our FEA. Additionally, the excellent correlation between the calculated critical flaw size and the defects observed at the primary fracture site demonstrates that field of experimental mechanics is a powerful predictive tool.