Seventeen-year clinical outcome of schizophrenia in Bali.

OBJECTIVE: To examine the 17-year clinical outcome of schizophrenia and its predictors in Bali. METHODS: Subjects were 59 consecutively admitted first-episode schizophrenia patients. Their clinical outcome was evaluated by standardized symptomatic remission criteria based on Positive and Negative Syndrome Scale (PANSS) scores and operational functional remission criteria at 17-year follow-up. The standardized mortality ratio (SMR) over 17 years was also calculated as another index of clinical outcome. RESULTS: Among these 59 patients, 43 (72.9%) could be followed-up, 15 (25.4%) had died, and one (1.7%) was alive but refused to participate in the study. Combined remission (i.e. symptomatic and functional remission) was achieved in 14 patients (23.7% of original sample). Duration of untreated psychosis (DUP) was a significant baseline predictor of combined remission. Mean age at death of deceased subjects was 35.7, and SMR was 4.85 (95% CI: 2.4-7.3), indicating that deaths were premature. Longer DUP was associated with excess mortality. CONCLUSIONS: The long-term outcome of schizophrenia in Bali was heterogeneous, demonstrating that a quarter achieved combined remission, half were in nonremission, and a quarter had died at 17-year follow-up. DUP was a significant predictor both for combined remission and mortality.

Eleven-year clinical outcome of schizophrenia in Bali.

OBJECTIVE: To contrast the short-term and long-term outcome of schizophrenia in Bali. METHOD: The clinical outcomes of 46 schizophrenic patients (DSM-IV-TR) consecutively admitted to Bangli Mental Hospital were evaluated by Positive and Negative Syndrome Scale (PANSS) and Eguma's Social Adjustment Scale (ESAS) at a 11-year follow-up, which was subsequent to a 5-year follow-up. RESULTS: Neither the PANSS score nor the ESAS score were significantly different, and there was a significant correlation between the two follow-up data. Subjects categorized into either the best or worst outcome group at the 5-year follow-up tended to be classified into the same category at the 11-year follow-up more often than those who were categorized into the medium outcome groups at the 5-year follow-up. CONCLUSION: The 5-year outcome of schizophrenia strongly predicted the 11-year outcome, especially for subjects who had gone into either a remissive or severe deterioration state within 5 years.