Can pelvic radiotherapy induce a leiomyosarcoma of the prostate? (A case report).

Leiomyosarcoma of the prostate is an extremely rare neoplasm. It represents less than 0.1% of all prostate malignancies. It is considered to have a poor prognosis, an aggressive nature, and high metastatic potential. Additionally, the relationship between radiation exposure for the treatment of primary prostatic cancer and the occurrence of leiomyosarcoma as second cancer at the irradiated site is rare, with unknown etiology. We reported a 72-year-old male known case of prostate adenocarcinoma with radio-hormonotherapy for six years who presented with acute urinary retention. Magnetic resonance imaging revealed a large malignant obstructive prostate with direct invasion of surrounding organs and multiple metastases. Trans-urethral resection of the prostate was performed, and the histopathology result showed high-grade leiomyosarcoma. The patient passed away after four months due to multiorgan failure. In conclusion, there may be a causal relationship between radiation therapy to the prostate and the development of prostate leiomyosarcoma.

Penile calciphylaxis in a patient with end-stage renal disease and chronic hemodialysis: a case report.

Penile calciphylaxis is a rare and highly morbid condition mainly affecting diabetic patients with chronic renal failure (CRF). It is characterized by ischemic skin ulceration and necrosis secondary to dystrophic calcification of the subcutaneous penile tissue and penile arterioles. We report a 52-year-old male with a 6-year history of diabetes mellitus and CRF on hemodialysis, who presented with a painful penile necrotic lesion in the last three weeks. He firstly treated with medical treatment, which was failed. Then underwent total penectomy. The histopathology result confirmed the diagnosis of penile calciphylaxis. Unfortunately, he passed away due to septic shock and multisystem organ failure ten days after surgery. In conclusion, the diagnosis of penile calciphylaxis must be evoked in the presence of any minimal necrotic penile lesion in a patient with CRF; this will initiate quick medical and/or minimally invasive surgical treatment to improve the patient's prognosis and avoid serious complications.

An efficient approach based on 3D reconstruction of CT scan to improve the management and monitoring of COVID-19 patients.

PURPOSE: To reconstruct a 3D visualization from CT images of COVID-19 patients in order to improve understanding of the disease for better management and follow-up. MATERIALS AND METHODS: We have retrieved CT images of 185 COVID-19 patients from the Cheikh Zaid International University Hospital in Rabat, Morocco. We then performed computer processing that allowed us to obtain a 3D visualization of these patients. RESULTS: In this article, we have chosen to do 3D reconstruction of three specific cases among 185 patients:- Cases (A1, A2) which are negative RT-PCR patient with normal CT images.- Cases (B1, B2) which are positive RT-PCR patient with abnormal CT images.- Case (C) which is a negative RT-PCR patient with CT abnormalities.To improve our results and have a better quality of the 3D reconstruction, we used different algorithms and a specific row data processing. CONCLUSION: 3D reconstruction has a significant role in the diagnosis and management of COVID-19 patients. The quality and reliability of 3D reconstructions allow the clinician to make a quick and efficient diagnosis and avoid an eventual false negative (produced by the RT-PCR test). We suggest including chest 3D reconstruction in the patient management and prognosis evaluation.