Effect of infiltrating immune cells in tumor microenvironment on metastasis of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent human malignancies, leading to poor prognosis due to its high recurrence and metastasis rates. In recent years it has become increasingly evident that the tumor microenvironment (TME) plays an important role in tumor progression and metastasis. Tumor microenvironment (TME) refers to the complex tissue environment of tumor occurrence and development. Here, we summarize the development of HCC and the role of cellular and non-cellular components of the TME in the metastasis HCC, with particular reference to tumor-infiltrating immune cells. We also discuss some of the possible therapeutic targets for the TME and the future prospectives of this evolving field. SIGNIFICANCE: This review provides a comprehensive analysis of the role of the infiltrating immune cells in TME in the metastasis of HCC and highlights the future outlook for targeted therapy of the TME in the context of recent experiments revealing a number of therapeutic targets targeting the TME.

High-sensitivity distributed transverse load sensor with an elliptical-core fiber based on Brillouin dynamic gratings.

A high-sensitivity distributed transverse load sensor based on Brillouin dynamic gratings (BDGs) is proposed and demonstrated experimentally for the first time, to the best of our knowledge. The principle is to measure the transverse-load-induced birefringence change through exciting and probing a BDG in an elliptical-core polarization-maintaining fiber. A distributed measurement of transverse load is demonstrated experimentally using a 10 m sensing fiber, which features high sensitivity to a transverse load with a measurement accuracy as high as 0.8×10(-3) N/mm at a 20 cm spatial resolution.