On the history of neuroscience research in the Max Planck Society, 1948-2002-German, European, and transatlantic perspectives: Introduction.

To further our understanding of the transformations of the modern, globalized world, historical research concerning the twentieth century must acknowledge the tremendous impact that science and technology exerted and continue to exert on political, economic, military, and social developments. To better comprehend a global history of science, it is also crucial to include Germany's most prominent research organization: The Max Planck Society for the Advancement of Science (MPG). Despite the existence of numerous institute chronicles and selected anniversary editions, the overall development of the MPG-historically situated in more than 80 institutes with more than 250 research service departments (of which approximately 50 have reached into the wider field of neuroscience, behavioral science, and cognitive science)-it remains largely terra incognita from a scholarly perspective. From June 2014 to December 2022, the Research Program on the History of the Max Planck Society (GMPG) opened previously neglected vistas on contemporary history, academic politics, and economic developments of the Federal Republic of Germany and its international relations by raising questions such as these: Who were the key scientific actors? In what networks did they work? In what fields had the MPG paved the way for cutting-edge innovations? What were its successes and where did it fail? In what ways were its institutional structures connected to its scientific achievements and its historical legacies? What is specific about the MPG in comparison to other national institutions in and outside of Germany? These questions relate to the emerging interdisciplinary field of the neurosciences. They refer in part to the MPG's founding years-from the late 1940s to the mid-1960s-which faced significant challenges for a "normalization process" in biomedical research and the burgeoning field of neuroscience. This special issue of the Journal of the History of the Neurosciences is composed of an introduction, five articles, and two neuroscience history interviews. It reflects on the multifold dimensions of behavioral psychology, brain research, and cognitive science developments at the MPG since its beginning through the reopening of several former Kaiser Wilhelm Institutes. After World War II, the extra-university research society-named in honor of physicist Max Planck (1858-1947)-was eventually established in the British Occupation Zone in 1946, in the American Zone in 1948, and in 1949 in the French Zone, unifying the MPG as the successor umbrella organization of the Kaiser Wilhelm Institutes (KWIs), now transformed into Max Planck Institutes. Chronologically, the research period covered in this special issue ranges from 1948 to 2002.

The neurosciences at the Max Planck Institute for Biophysical Chemistry in Göttingen.

The Max Planck Institute (MPI) for Biophysical Chemistry (Karl-Friedrich Bonhoeffer Institute) was founded in 1971 in Göttingen. Two of the 11 departments at the institute had a neuroscientific focus. Otto D. Creutzfeldt (1927-1992) and Victor P. Whittaker (1919-2016) were directors of the Neurobiological and Neurochemical Departments, respectively. Creutzfeldt's department researched the structure and function of the cerebral cortex, and Whittaker's department concentrated on the biochemical analysis of synapses and synaptic vesicles. Creutzfeldt and Whittaker were already internationally respected scientists when they were appointed to Göttingen. The next generation of departmental directors, Erwin Neher and Bert Sakmann, were "home-grown" researchers from the institute and, during their time as junior group leaders, they developed the so-called patch clamp technique, with which they were able to measure single ion channels in nerve cells. This technique revolutionized neurophysiology, and Neher and Sakmann were awarded the 1991 Nobel Prize in Physiology or Medicine for their work in this area. Neher was appointed director of the Membrane Biophysics Department in 1983 and, since then, his department has mainly examined the role of Ca2+ in the release of neurotransmitters at synapses and in the secretion of catecholamines from chromaffin cells. From 1985, Sakmann was director of the Cell Physiology Department, and his laboratory concentrated on the molecular and physiological characterization of transmitter receptors in postsynaptic membranes. In 1989, he was appointed to the MPI for Medical Research in Heidelberg. Reinhard Jahn became director of the Neurobiology Department in 1997, researching the molecular mechanisms of the release of neurotransmitters from the presynaptic terminals, and he discovered several proteins associated with the synaptic vesicles. With their work, Neher, Sakmann, and Jahn have made the MPI for Biophysical Chemistry one of the world's leading research centers for the transmission of signals at synapses.

Neuroscience history interview with Professor Wolf Singer, emeritus director at the Department of Neurophysiology, Max Planck Institute for Brain Research in Frankfurt am Main.

Dr. Wolf Singer (b. 1943) is one of Germany's most renowned brain researchers and neurophysiologists. His accomplishments in the creation of new research centers for neuroscience as well as his commitment to European scientific organizations for integrative brain research are highly valued as significant moments of advancement in the neurosciences. Before his appointment as a scientific member of the Max Planck Society and director at the Frankfurt Max Planck Institute for Brain Research, he gained deep insight into the chances and pitfalls of translational initiatives at the Max Planck Institute of Psychiatry in Munich. From the late 1950s onward, the institute adapted to emerging international trends and successfully integrated neurochemistry, neurophysiology, and neuroanatomy into the fledgling interdisciplinary field of neuroscience. This agenda of reorientation was an undertaking of Otto Detlev Creutzfeldt, Detlev Ploog, Gerd Peters, and Horst Jatzkewitz, among others. In the 1970s, Munich's laboratories attracted scientists from several countries in Europe and abroad. This article examines whether specific styles of conducting (neuro)science research existed in the Max Planck Society.

[The province of East Prussia and "euthanasia" during national socialism: the SS-"Aktion Lange" and "Aktion T4"]. / Die Provinz Ostpreussen und die nationalsozialistische "Euthanasie": SS-",Aktion Lange" und "Aktion T4".

During World War II, psychiatric patients hospitalized in asylums in Eastern Prussia became victims of two separate killing programmes: first, by the SS-special command Lange, second by the centrally (in Berlin) organized "euthanasia"-"Aktion T4". By an analysis of the patient files of the victims, the present paper shows that the historical actors responsible for the killings were communicating with each other. It is now also possible to reconstruct the exact dynamic in time and space of the killings. A comparative analysis of the selection criteria within the total population of the asylums documents that in both programs, the responsible historical actors included physicians and provincial administrative personnel; it further shows that under the conditions of war, only patients who were able to contribute to the asylum work and economy, and were behaviourally adapted could survive.