RESUMO
Malignant melanoma is the most aggressive form of skin cancer showing extremely high metastatic rate and leading to high levels of lethality. The continually growing incidence of malignant melanoma in the world and his difficult early diagnosis are the occasion for numerous studies. The individual risk for malignant transformation of melanocytes is determined by a number of etiologic factors--endogenous and exogenous. Ultraviolet radiation has a leading role in the group of exogenous factors. Within the group of endogenous factors, besides the well-known photo type skin, as well as genes mutations, are added and the sex hormones, with their significant prognostic importance. The differences, which are observed in the progression and prognosis of malignant melanoma in pre- and postmenopausal women, and men, have defined this cutaneous neoplasma as hormone-dependent tumor. We present two seemingly similar clinical cases of 52 year old woman and 53-year-old man diagnosed with malignant melanomas, developed on the basis of pigmented lesions located on the upper back, as we attempt a comparative analysis on etiopathogenetic factors led to radically different course and prognosis of the disease in these two patients.
Assuntos
Melanoma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Pele/patologia , Procedimentos Cirúrgicos Dermatológicos , Progressão da Doença , Feminino , Humanos , Masculino , Melanoma/etiologia , Melanoma/patologia , Melanoma/cirurgia , Pessoa de Meia-Idade , Prognóstico , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgiaRESUMO
Congenital melanocytic nevi are common subject of scientific debates nowadays, because of their possibility for transformation in malignant melanoma, although relatively rare. The diagnosis is difficult, due to their non-specific clinical and histological presentation, while the therapeutic methods are varied, depending on their size and localization. Surgical excision, however, is the most secure among them, because a complete removal of the lesion could be achieved, which, firstly provides a prevention of a possible malignant transformation, as well as this approach provides material for histological examination. We present a case of a 23-year-old female patient with congenital melanocytic nevus, located on the upper back, which increased significantly its size during her pregnancy, successfully treated by single surgical excision, with excellent aesthetic results.
Assuntos
Nevo Pigmentado/cirurgia , Complicações Neoplásicas na Gravidez/cirurgia , Neoplasias Cutâneas/cirurgia , Adulto , Procedimentos Cirúrgicos Dermatológicos , Feminino , Humanos , Nevo Pigmentado/diagnóstico , Nevo Pigmentado/patologia , Gravidez , Complicações Neoplásicas na Gravidez/diagnóstico , Complicações Neoplásicas na Gravidez/patologia , Ombro/patologia , Ombro/cirurgia , Pele/patologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/patologia , Adulto JovemRESUMO
Malignant melanoma is the most aggressive form of skin cancer showing extremely high metastatic rate and leading to high levels of lethality. The continually growing incidence of malignant melanoma in the world and his difficult early diagnosis are the occasion for numerous studies. The individual risk for malignant transformation of melanocytes is determined by a number of etiologic factors--endogenous and exogenous. Ultraviolet radiation has a leading role in the group of exogenous factors. Within the group of endogenous factors, besides the well-known photo type skin, as well as genes mutations, are added and the sex hormones, with their significant prognostic importance. The differences, which are observed in the progression and prognosis of malignant melanoma in pre- and postmenopausal women, and men, have defined this cutaneous neoplasma as hormone-dependent tumor. We present two seemingly similar clinical cases of 52 year old woman and 53-year-old man diagnosed with malignant melanomas, developed on the basis of pigmented lesions located on the upper back, as we attempt a comparative analysis on etiopathogenetic factors led to radically different course and prognosis of the disease in these two patients.
Assuntos
Melanoma/patologia , Neoplasias Hormônio-Dependentes/patologia , Neoplasias Cutâneas/patologia , Pele/patologia , Feminino , Humanos , Masculino , Melanoma/diagnóstico , Melanoma/etiologia , Melanoma/genética , Pessoa de Meia-Idade , Neoplasias Hormônio-Dependentes/diagnóstico , Neoplasias Hormônio-Dependentes/etiologia , Neoplasias Hormônio-Dependentes/genética , Prognóstico , Fatores de Risco , Pele/efeitos da radiação , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/genética , Raios UltravioletaRESUMO
We report a case of a pregnant woman with PNH. She was at 31 w.g. During the pregnancy our patient was hypertransfused and used anticoagulation treatment. The patient developed Preeclampsia, Intra-uterine growth retardation and Oligohydramnion. An induced vaginal delivery was done. A healthy child was delivered. There were no other postpartum complications. She was discharged from hospital in satisfactory condition.