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Nat Commun ; 11(1): 510, 2020 01 24.
Artigo em Inglês | MEDLINE | ID: mdl-31980636

RESUMO

Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus aegyptiacus) as a natural reservoir. However, the largest recorded MVD outbreak with the highest case-fatality ratio happened in 2005 in Angola, where direct spillover from bats was not  shown. Here, collaborative studies by the Centers for Disease Control and Prevention, Njala University, University of California, Davis USAID-PREDICT, and the University of Makeni identify MARV circulating in ERBs in Sierra Leone. PCR, antibody and virus isolation data from 1755 bats of 42 species shows active MARV infection in approximately 2.5% of ERBs. Phylogenetic analysis identifies MARVs that are similar to the Angola strain. These results provide evidence of MARV circulation in West Africa and demonstrate the value of pathogen surveillance to identify previously undetected threats.


Assuntos
Quirópteros/virologia , Marburgvirus/isolamento & purificação , África Ocidental , Animais , Cavernas , Genoma Viral , Geografia , Funções Verossimilhança , Doença do Vírus de Marburg/virologia , Marburgvirus/classificação , Marburgvirus/genética , Filogenia , Análise de Sequência de DNA , Proteínas Virais/metabolismo
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