Assuntos
Angiofluoresceinografia , Miopia/diagnóstico , Descolamento Retiniano/diagnóstico , Perfurações Retinianas/diagnóstico , Tomografia de Coerência Óptica , Idoso , Atrofia , Extração de Catarata , Corioide/patologia , Criocirurgia , Feminino , Seguimentos , Humanos , Macula Lutea/patologia , Oftalmoscopia , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/cirurgia , Reoperação , Retina/patologia , Descolamento Retiniano/cirurgia , Recurvamento da Esclera , Corpo Vítreo/patologia , Descolamento do Vítreo/diagnósticoRESUMO
We reported two cases strongly suspected of ocular toxoplasmosis, in which a puncture of anterior eye chamber was performed for a final verification of clinical diagnosis. In both patients, fresh focal lesions of retinochoroiditis associated with old pigmented retinal scars were diagnosed. The 62-year-old women had a serological evidence of recently acquired T. gondii infection with an increasing IgG titre of a low avidity and a presence of specific IgM and IgA antibodies. In the 13-year-old girl, an immunological profile of the chronic infection was shown, confirmed by a high IgG avidity value. In the patient with a clinical picture of recurrent congenital toxoplasmosis, intraocular production of T. gondii-specific IgG was found in anterior eye chamber. The analysis of the specific antibodies synthesis in ocular fluid by the Western blot seems to be a valuable immunodiagnostic method for a final diagnosis of ocular toxoplasmosis.
Assuntos
Anticorpos Antiprotozoários/análise , Humor Aquoso/parasitologia , Coriorretinite/diagnóstico , Imunoglobulinas/análise , Toxoplasmose Congênita/diagnóstico , Toxoplasmose Ocular/diagnóstico , Adolescente , Animais , Humor Aquoso/imunologia , Coriorretinite/parasitologia , Feminino , Humanos , Pessoa de Meia-Idade , Recidiva , Testes Sorológicos , Toxoplasma/isolamento & purificação , Toxoplasmose Congênita/parasitologia , Toxoplasmose Ocular/parasitologiaRESUMO
The effectiveness of neonatal screening for anti-Toxoplasma IgM or IgA and IgM specific antibodies followed by an intensive anti-parasitic therapy for a prevention of clinical and immunological reactivations of congenital infection was studied. Thirty-five congenitally infected infants were included into clinical and serological follow-up. The children were mostly asymptomatic at birth or they expressed some non-specific reversible clinical abnormalities in neonatal period. Clinically overt toxoplasmosis occurred in 10 patients, including one infant with a severe form; 2 children had co-existing CMV infections. During the follow-up period, no clinical relapses were reported. Asymptomatic immunological rebounds of IgG or of IgG and IgA specific antibodies were observed in 16 patients. Anti-parasitic treatment initiated soon after birth seems to be promising in a prevention of early clinical sequelae of congenital T. gondii infection.