[Use of microcolon gradient high performance liquid chromatography for urine dimedrol assay in combined poisoning].

A technique of a rapid urine dimedrol assay by gradient microcolon high performance liquid chromatography is proposed. Dimedrol is detected selectively in the presence of large amounts of medicinal and narcotic substances metabolites. Threshold of detectability was 0.005 mcg/ml, optimal range of quantitation -0.02 - 1 mcg/ml, extraction degree in sampling -85%. It was found that concentration of dimedrol in the urine obtained for chemicotoxicological tests ranges from 0.01 to 2.5 mcg/ml. Establishment of dimedrol intake by presence of its metabolites was studied.

[The methodological aspects and prospects of using dynamically modified sorbents for the analysis of biological specimens by means of high-performance liquid chromatography]. / Metodicheskie aspekty i perspektivy primeneniia dinamicheski modifitsirovannykh sorbentov dlia analiza biologicheskikh ob''ektov s pomoshch'iu vysokoéffektivnoi zhidkostnoi khromatografii.

Published reports and authors' experience gained in high-performance liquid chromatographic analysis of dynamically modified adsorbents are reviewed. The advantages of this variant of liquid chromatography are shown: the method is economic and more effective for analysis of mixtures of a complex composition, including biological objects. Examples of mycotoxin, morphine, and other toxicologically significant agents are offered. The method is recommended for wide use in forensic medical expert evaluations.