RESUMO
Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatry disorder with several key symptoms, such as inattentiveness, impulsivity and hyperactivity. Neuropsychiatry studies have implicated the frontostriatal circuit in the pathological physiology of the disorder. Using magnetic resonance imaging (MRI), we examined the basal ganglia in 13 ADHD patients and eight unaffected comparison children. The volume of caudate, putamen and globus pallidus was measured. In the ADHD patients, we detected an increased left > right asymmetry of the basal ganglia. This reversal of asymmetry in the globus pallidus and caudate nucleus were statistically significant. These finding provide further evidence of morphological brain abnormalities in ADHD.
Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/patologia , Gânglios da Base/anatomia & histologia , Lateralidade Funcional , Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Gânglios da Base/anormalidades , Gânglios da Base/patologia , Estudos de Casos e Controles , Núcleo Caudado/anormalidades , Núcleo Caudado/anatomia & histologia , Núcleo Caudado/patologia , Estimulantes do Sistema Nervoso Central/uso terapêutico , Criança , Feminino , Humanos , Masculino , Metilfenidato/uso terapêutico , Tamanho do Órgão , Valores de Referência , Estatísticas não ParamétricasRESUMO
Fertilization treatment is established therapy of infertility in the cases, where other approaches have failed or were impossible. In eating disorders, majority of fertility problems has been secondary and so fully reversible if appropriately treated. Fertilization treatment should not be used in patients refusing the psychological treatment of the illness. In patients in active phase of the illness fertility treatment at fertility are contra-indicated. Two cases of negative impact of fertility treatment in patients with anorexia nervosa are presented.
Assuntos
Anorexia Nervosa/complicações , Infertilidade Feminina/terapia , Técnicas de Reprodução Assistida , Adulto , Anorexia Nervosa/terapia , Criança , Transtornos da Nutrição Infantil/psicologia , Feminino , Humanos , Infertilidade Feminina/etiologiaRESUMO
ADHD (attention hyperactivity disorder) is a polygenetic disorder with various candidate genes. At this time, more than thirty dopaminergic, noradrenergic, serotonergic and GABA-ergic genes are known. The research of only some candidate genes (DRD4, DAT, DRD5, DBH, 5HTT, HTR1B and SNAP25) brought relatively consistent results confirming the heredity of ADHD syndromes. The results of research of other genes (DRD2, DRD3, MAO, ADR2A, GABA A3, GABA B3) are not clear yet. This paper summarizes the most important genetic data in correlations with biochemical periphery parameters (especially for DBH, HVA, MHPG, serotonin). Hypothetically, certain subgroups of ADHD may be identified by correlation of biochemical characteristics and some candidate genes. The paper discusses some implications for future research. Review.