RESUMO
The bark of Dalbergia lanceolaria was undertaken for evaluation of antidiarrhoeal activity in albino mice based on ethnobotanical lead. This bark was collected from Khanapur area of Western Ghats near Pune, Maharashtra, India. The successive solvent extraction of bark was carried out after drying, using petroleum ether (60-80 degrees C) and ethanol in soxhlet apparatus. The ethanol extract showed activity against castor oil, magnesium sulphate induced diarrhoea in albino mice. The extract was also studied for castor oil induced intraluminal fluid accumulation as well as charcoal transit in normal and barium chloride treated animals. The extract reduced significantly intraluminal fluid accumulation and intestinal motility.
Assuntos
Antidiarreicos/uso terapêutico , Dalbergia , Diarreia/tratamento farmacológico , Fitoterapia , Extratos Vegetais/uso terapêutico , Animais , Óleo de Rícino/farmacologia , Feminino , Trânsito Gastrointestinal/efeitos dos fármacos , Mucosa Intestinal/efeitos dos fármacos , Mucosa Intestinal/metabolismo , Sulfato de Magnésio/farmacologia , Masculino , CamundongosRESUMO
Use of Jatropha curcus L. roots in the treatment of diarrhoea is a common ethnobotanical practice in Konkan, a part of the Western coastal area of India. Roots of this species were undertaken for pharmacognostic studies and evaluation of antidiarrhoeal activity in albino mice. Successive solvent extraction was carried out using petroleum ether (60-80 degrees C) and methanol. The methanol extract showed activity against castor oil induced diarrhoea and intraluminal accumulation of fluid. It also reduced gastrointestinal motility after charcoal meal administration in albino mice. The results indicate that action of J. curcus root methanol extract could be through a combination of inhibition of elevated prostaglandin biosynthesis and reduced propulsive movement of the small intestine.
Assuntos
Antidiarreicos/farmacologia , Plantas Medicinais , Animais , Óleo de Rícino , Feminino , Motilidade Gastrointestinal/efeitos dos fármacos , Índia , Mucosa Intestinal/efeitos dos fármacos , Mucosa Intestinal/metabolismo , Masculino , Camundongos , Extratos Vegetais/farmacologia , Plantas Medicinais/químicaRESUMO
Five difference species of plants are known as Kade-Chirayet in different parts of Pune and neighbouring districts. Botanical identification of all the five species is presented in this paper.