[The blood biochemical indicators as possible markers of destruction of kerato-hyaline tissue of nails in patients with onycholysis].

It is established that the most informative blood biochemical indicators of destructive process in patients with onycholysis are to be considered concentration of oxiproline in blood. The changing of ratio of fractions oxiproline, balance between concentration of enzymes of antioxidant defense and metalloproteinase and concentration of hemoglobin in blood make it possible to diagnose the mixed type of hypoxemia which is a possible cause of destruction of kerato-hyaline tissue in patients with onycholysis.

[Peptide-bound oxyproline content in patients with nail hyperkeratosis and lactic acidosis].

The studies indicate that women with dystrophic changes of the nail in the presence of various skin diseases show a significant blood accumulation of acid products (peptide-bound oxyproline (PO) and lactic acid (LA). A relationship was found between the magnitude of a dystrophic process (hyperkeratosis) and higher blood LA levels with lower PO values that fail to achieve the level observed in the control group.

[The activities of red blood cell superoxide dismutase and catalase and serum alkaline phosphatase in onychodystrophy in women in the stage of nail rejection].

The resistance to a dystrophic process and lysis and the degree of clinical signs in nail lesions in different stages of onychodystrophy were found to be associated with the activity of alkaline phosphatase. A relationship was established between the magnitude of the blood activity of the enzymes superoxide dismutase and catalase with a drop in the serum activity of alkaline phosphatase. At the same time, there was a correlation between the rate of development of onychodystrophy and the magnitude of a change in the activity of antioxidant defense enzymes.

[Peptide-bound oxyproline and the activity of alkaline phosphatase in the serum of women with onychodystrophy].

A clinicobiochemical analysis has revealed a relationship between the elevated peptide-bound oxyproline levels and the lower activity of alkaline phosphatase in women and the presence of the early symptom stratified nails. The degree of the elevated peptide-bound oxyproline levels is informative of the early manifestations of the damage, which is of diagnostic value and enables treatment to be used in proper time. In a group of young subjects with onychodystrophy, the significant increase of peptide-bound oxyproline with the decreased activity of alkaline phosphatase in the serum may reflect the activation of adaptive reactions. The older the organism is, the less intensity of an adaptive reaction to hypoxia that is a principal of onychodystrophy.

[Reactive changes in hemopoiesis in hymenolepiasis]. / Reaktivnye izmeneniia krovetvoreniia pri gimenolepidoze.

Signs of hypoplastic anemia in experimental hymenolepiasis become manifest when immature cestodes develop and gain severity at the stage of mature cestodes. Phagocytic activity of neutrophils acquires an undulating pattern. Dehelminthization of mice with fenasal (1000 mg/kg/day) or asinox (75 mg/kg, daily) made hypoplastic processes in the bone marrow reversible and precluded routine undulation of phagocytosis.