Comparison mitochondrial DNA DAMPs changes in platelet prepared by apheresis and PRP.

INTRODUCTION: Mt DNA (DAMPs) plays a key modulatory role in immune cells and may also mediate a variety of adverse transfusion reactions. MATERIAL AND METHOD: The cross-sectional study was performed on 22 (PRP) and 14 (SDP) between February 2019 and 2020. mtDNA DAMPs by quantitative real-time PCR was assessed on days 1, 3, and 5 of platelets storage. The data was entered in REST 2009 software, and the amount of fold change was calculated. Multiple t tests were also used. RESULTS: The mtDNA DAMPs fold change in SDP on days 1-3, 1.3 times, on days 3-5, 1.5 times, and on days 1-5, 2.1 times increased. The fold change on days 1-3, 0.8 times, on days 3-5, 0.6 times, and on days 1-5, 0.49 times decreased in PRP products. CONCLUSION: The method of preparation and processing can affect mtDNA DAMPs fold changes.

The Effects of Comprehensive Home-Based Cardiac Rehabilitation versus Usual Care in Patients with Ischemic Heart Disease in Iran: Study Protocol for a Multicenter Randomized Controlled Trial.

Background: Cardiovascular diseases are the leading causes of mortality all around the world. Patients with Ischemic heart disease (IHD) are at an increased risk of ischemic events; therefore, secondary prevention measures should continue for these patients. Although Cardiac rehabilitation (CR) is one of the secondary prevention measures for IHD patients which has favorable clinical outcomes, only 50% of patients are referred and among them, a small percentage attends CR. Therefore, other strategies should be considered, one of which is home-based cardiac rehabilitation. Methods: A multicenter, parallel-group randomized controlled trial has been conducting in three hospitals in Isfahan and patients have been assigned into a 1:1 ratio for the evaluation of the effectiveness of home-based cardiac rehabilitation versus usual care. Psycho-educational consultation based on the Health Action Process Approach including heart-healthy diet, stress management, lifestyle changes, smoking cessation, and physical activity has been performed. Primary outcomes, including the quality of life, psychological and smoking status, body mass index, blood pressure, blood cholesterol level, and physical activity level have been measured at 6 months after the randomization and intervention. One year after the intervention, primary and secondary outcomes, including cardiovascular events, the frequency of hospital admissions, and the death rates due to cardiovascular reasons will be assessed. Conclusion: HBCR program can increase patient accessibility to CR services its implantation can be reduce burden IHD.

The effect of home-based cardiac rehabilitation on depression score in patients with ischemic heart disease: A longitudinal clinical trial study.

BACKGROUND: Depression is common in patients with cardiovascular disease (CVD). Home-based cardiac rehabilitation (HBCR) is a program that alleviates depression. This study aimed to determine and compare HBCR programs and usual care (UC) effects on depression control in patients with ischemic heart disease (IHD). METHODS: This clinical trial study was performed on 259 patients with IHD that were randomly allocated to the HBCR and UC groups for stress management. Data were collected using the "Beck Depression Inventory" (BDI) at baseline and 6 and 12 months. Generalized estimating equation (GEE) models were applied to examine the associations between times of the groups and changes in outcomes over the study times. Data analysis was done in SPSS software at the significance level of 0.05. RESULTS: A total of 247 participants with a mean age of 55.22 ± 7.40 years participated in this study, and 209 (84.6%) of the study participants were men. Among patients, 128 patients in the UC program and 119 patients in the HBCR program attended at least one of the pre-determined visits (months 6 and 12). The patterns of change of the depression parameter were similar through the course of the study between the two groups (P = 0.04). In the HBCR group, the depression reduced continuously from baseline to 6 months, baseline to 12 months, and 6 to 12 months (P < 0.05). In the UC group, depression was significantly reduced from baseline to 6 months and from baseline to 12 months. CONCLUSION: HBCR was effective in continuous reducing of depression scores in long-term follow-up of patients with IHD. These findings suggest that HBCR can alleviate depression in patients who do not participate in hospital-based cardiac rehabilitation (CR).

Prevalence of Common Postural Disorders Among Academic Dental Staff.

BACKGROUND: Musculoskeletal disorders are common problems among dentists. These conditions may lead to inappropriate postures and impairment in physical and psychological function. On the other hand, poor postures and inappropriate ergonomic may result in a wide variety of musculoskeletal disorders. OBJECTIVES: The aim of this study was to investigate the prevalence of common postural disorders of the spine and shoulder girdle among the dentists and possible correlations between demographic, anthropometric and occupational characteristics with these abnormal postures. PATIENTS AND METHODS: In a cross-sectional study, 96 dental staff including academic staff, residents and senior students of Tehran University of Medical Sciences was enrolled. Data were collected using a questionnaire and posture assessment tools such as plumb-line, checkerboard and flexible ruler. Data analysis was done with SPSS version 17. RESULTS: The prevalence of the forward head posture (FHP), rounded shoulder posture (RSP), scoliosis and hyperlordosis were reported in 85.5%, 68.8%, 18.8% and 17.3% of the participants, respectively. A significant correlation was found between gender and FHP (P = 0.04) and also scoliosis (P = 0.009). On the other hand, a significant correlation was seen between weight and hyperlordosis (P = 0.007). CONCLUSIONS: Our study revealed a high prevalence of postural disorders especially FHP, RSP and scoliosis among Iranian dental staff. The female dentists were less susceptible to FHP and scoliosis.