RESUMO
High density lipoproteins (HDL) are small plasma particles which may be able to pass through the blood-brain barrier. We have therefore studied the fatty acids of HDL in patients with dementia to determine whether the changes are consistent with those previously reported in brain tissue. The HDL phospholipid and the HDL cholesteryl ester both showed reduced concentrations of arachidonic acid (20:4n6) as compared to normal controls. HDL may be a useful plasma fraction for study of lipids in neurodegenerative diseases.
Assuntos
Envelhecimento/metabolismo , Demência/metabolismo , Ácidos Graxos/análise , Lipoproteínas HDL/química , Idoso , Idoso de 80 Anos ou mais , Envelhecimento/patologia , Doença de Alzheimer/metabolismo , Doença de Alzheimer/psicologia , Ácido Araquidônico/metabolismo , Interpretação Estatística de Dados , Demência/psicologia , Ácido Eicosapentaenoico/metabolismo , Ácidos Graxos/química , Ácidos Graxos/metabolismo , Ácidos Graxos Insaturados/análise , Ácidos Graxos Insaturados/química , Ácidos Graxos Insaturados/metabolismo , Feminino , Humanos , Lipoproteínas HDL/metabolismo , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Fosfolipídeos/química , Fosfolipídeos/metabolismo , Estatísticas não Paramétricas , Triglicerídeos/química , Triglicerídeos/metabolismoRESUMO
To examine the relationship between plasma lipoproteins and apolipoproteins in men with convictions for violent offences, blood was obtained from 15 men with a history of violence who were serving prison sentences for violent offences, and 25 age-matched male controls from the staff of the Argyll and Bute Psychiatric Hospital, who had no criminal records. The two groups did not differ in plasma total cholesterol concentrations, HDL-C, LDL-C, VLDL-C or in HDL subfractions. The most significant differences in the offenders were higher apoprotein AIV (3.62 vs 0.85: p = < 0.000001) and higher apoprotein E (7.70 vs 5.19: p = < 0.0002).
Assuntos
Colesterol/metabolismo , Crime , Violência , Adulto , Apolipoproteínas/sangue , Humanos , Lipoproteínas/sangue , Lipoproteínas HDL/sangue , MasculinoRESUMO
Serum elements and fatty acids of red cell and plasma phospholipids, cholesterol esters and high density lipoproteins, were studied in patients with Alzheimer's disease (SDAT) and with multi-infarct dementia (MID). Increased 20:4n6 in MID was the finding most consistent in the different tissues. The red cell phospholipids were more unsaturated in MID than in SDAT but in SDAT the plasma phospholipids were more saturated. Serum Al, Sn and V concentrations were higher in SDAT than in MID while serum Mn concentrations were higher in MID. Sn and V correlated negatively with the unsaturation index of the red cell phospholipids and Sn showed a striking pattern of correlations with the red cell phospholipid fatty acids in SDAT: it was significantly positively correlated with 16:0 and 18:1n-9 and negatively correlated with 20 and 22 carbon n-3 and n-6 essential fatty acids. Since we have shown elevated tin levels in patients with Alzheimer's disease, and since organic tin compounds given to animals produce a syndrome with similarities to Alzheimer's disease, there is a need for investigation of the role of tin in lipid metabolism in dementia.
Assuntos
Demência/sangue , Ácidos Graxos/sangue , Estanho/sangue , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/sangue , Demência por Múltiplos Infartos/sangue , Eritrócitos/metabolismo , Feminino , Humanos , Masculino , Metais/sangue , Fosfolipídeos/sangueRESUMO
A case of renal cell carcinoma in a multilocular renal cyst is reported. Excretory urography showed a mass, and ultrasound revealed multiple renal cysts in the middle part of the left kidney. This finding could also be visualized by computer tomography, a solid structure could not be detected. During operation a 6-cm multiloculated cyst was enucleated from the left kidney. A frozen section of the cystic lesion did not indicate a malignancy; however, further histopathological examination revealed a renal cell carcinoma, especially in the septal parts of the tumor.