Hypotension in preterm infants with significant patent ductus arteriosus: effects of dopamine.

OBJECTIVE: To study the effects of dopamine on systemic arterial pressure (SAP) and systemic blood flow (SBF) (estimated with the superior vena cava [SVC] flow) in preterm infants with hypotension and patent ductus arteriosus (PDA). STUDY DESIGN: Clinical and echocardiographic variables were measured before and 2 hours after starting dopamine in premature infants <32 weeks gestational age with PDA and systemic hypotension. RESULTS: Seventeen premature infants were included (gestational age, 28+/-2 weeks; birth weight, 1030 +/- 400 g). A mean rate of 8 +/- 2 microg/kg/min of dopamine raised SAP from 30 +/- 3 to 41 +/- 5 mm Hg (P < .05), and the pulmonary artery pressures from 25 +/- 5 to 32 +/- 8 mm Hg (P < .05). The SVC flow increased by 30% (from 130 +/- 40 to 170 +/- 44 mL/kg/min; P < .05). The left ventricular output and the end-diastolic and mean left pulmonary artery blood flow velocities did not change despite the increase in pulmonary artery pressure. CONCLUSION: In preterm infants with hypotension and PDA, dopamine (<10 microg/kg/min) increases the systemic blood pressure and the systemic blood flow. Our results suggest that dopamine decreases left-to-right shunting across ductus arteriosus, caused by a rise in pulmonary vascular resistances.

Can we apply the European surveillance program of nosocomial infections (HELICS) to pediatric intensive care units?

OBJECTIVE: To evaluate the applicability of the HELICS program [part of the "Improving Patient Safety in Europe" program aiming at controlling nosocomial infections (NI) through surveillance] in European pediatric ICUs. DESIGN AND SETTING: A comparison of HELICS and pediatric definitions of the main NI was performed. The adaptability of the HELICS questionnaire for pediatric patients was examined. Then a European survey was carried out by e-mail questionnaire to analyze NI surveillance programs. PARTICIPANTS: Units affiliated with the European Society of Paediatric and Neonatal Intensive Care or the French Groupe Francophone de Réanimation et Urgences Pédiatriques. MEASUREMENTS AND RESULTS: The main differences between adult and pediatric ICUs were the definition of ICU-acquired pneumonia, severity scores at admission, and scores of risk for NI. A total of 65 answers from 23 countries were collected. Among them 56 had a NI surveillance program that was of local origin for 64%. The most frequently collected NI were blood stream infections (91% of the units), catheter-related infections (88%), acquired pneumonia (86%), and urinary tract infections (77%). Definitions of NI had a local-based origin in 18% of cases, a regional-based or nation-wide origin in 21%, came from the Centers for Disease Control and Prevention in 38% and had multiple origins in 20%. Seventy-five percent of the units declared an interest in joining a European pediatric working group on NI within the European Society of Paediatric and Neonatal Intensive Care. CONCLUSIONS: The adaptation of the HELICS protocol for pediatric ICUs is necessary. Its application is largely wished and may be easily performed.