RESUMO
Detailed study of a representative clinical sample and monitoring of 410 patients with ocular tuberculosis enabled the authors disclose the pathomorphosis and describe the clinical features of the disease. Tuberculosis of anterior location is observed at middle age and is characterized by frequent relapses, monolateral involvement, predominance of mixed and exudative inflammation, and high incidence of complications. Posterior tuberculous uveitis more often occurs in young people and is characterized by involvement of one or both eyes, productive inflammation, long remissions, and lesser incidence of complications.
Assuntos
Tuberculose Ocular/diagnóstico , Adolescente , Adulto , Fatores Etários , Catarata/complicações , Úlcera da Córnea/complicações , Feminino , Seguimentos , Glaucoma/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Descolamento Retiniano/complicações , Fatores Sexuais , Fatores de Tempo , Tuberculose Ocular/complicações , Uveíte/diagnósticoRESUMO
Based on clinical and immunological examinations of 251 patients with tuberculous uveitis (TU), 3 types of its course (productive, exudative, and mixed) were identified. The immunopathologic pattern of each type was found to be different: the productive type was characterized by delayed hypersensitivity, the exudative one had immediate hypersensitivity, and the mixed one had both. The immunogenetic markers of mixed TU were defined. These included HLA antigens, such as A2, B7, B21, and B27.
Assuntos
Mycobacterium tuberculosis/imunologia , Tuberculose Ocular/imunologia , Uveíte/imunologia , Adolescente , Adulto , Câmara Anterior/microbiologia , Câmara Anterior/patologia , Anticorpos Antibacterianos/análise , Criança , Infecções Oculares Bacterianas/etiologia , Infecções Oculares Bacterianas/imunologia , Infecções Oculares Bacterianas/patologia , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Linfócitos T/imunologia , Lágrimas/microbiologia , Tuberculina/imunologia , Tuberculose Ocular/etiologia , Tuberculose Ocular/patologia , Uveíte/microbiologia , Uveíte/patologiaRESUMO
Clinical and immunological studies carried out in 251 patients with tuberculous uveitis (TU) revealed three types of inflammatory reactions in the uveal tract in this patient population: productive, exudative, and productive-exudative (mixed), differing by the type of immune disorders. The findings helped develop a clinical immunological classification of TU, taking account of the clinical form of uveitis, type of inflammatory reaction of the uveal tract, disease pattern, involvement of one or both eyes, complications, and the immunopathological variants of TU course.