RESUMO
Wood pellets have gained global attention due to their economic availability and increasing demand for bioenergy as part of sustainable energy solutions. Management of the wood pellet supply chains, from feedstock harvesting to bioenergy conversion, is critical to ensure competitiveness in the energy markets. In this regard, wood pellets supply chain coordination can play a strategic role in enhancing the efficiency and reliability of bioenergy generation. This study proposes a contract-based coordination mechanism for wood pellet supply chains and compares its performance in alternative centralized and decentralized decision-making structures. A bi-level nonlinear game-theoretic approach with two economic and environmental objective functions is developed. It utilizes the concept of life cycle assessment in a Stackelberg leader-follower game to obtain the bioenergy equilibrium solutions. Further, this study examines the case of wood pellet supply chains in three remote Canadian communities. The aim is to showcase the practicality and significance of the proposed approach and interpret the findings. By focusing on these communities, the crucial role of supply chain coordination in fostering sustainable development, particularly, in the context of bioenergy generation is emphasized. The study colludes by advocating a number of avenues for future research.
RESUMO
Although leishmaniasis is one of the most common parasitic diseases, its traditional treatments suffer from some serious problems. To solve such issues, we can take advantage of the effective nanoparticle-based approaches to deliver anti-leishmanial agents into leishmania-infected macrophages either using passive targeting or using macrophage-related receptors. Despite the high potential of nanotechnology, Liposomal Amphotericin B (AmBisome®) is the only FDA-approved nanoparticle-based anti-leishmanial therapy. In an effort to find more anti-leishmanial nano-drugs, this 2011-2021 review study aimed to investigate the in-vivo and in-vitro effectiveness of poly (lactic-co-glycolic acid) nanoparticles (PLGA-NPs) in the delivery of some traditional anti-leishmanial drugs. Based on the results, PLGA-NPs could improve solubility, controlled release, trapping efficacy, bioavailability, selectivity, and mucosal penetration of the drugs, while they decreased resistance, dose/duration of administration and organotoxicity of the agents. However, none of these nano-formulations have been able to enter clinical trials so far. We summarized the data about the common problems of anti-leishmanial agents and the positive effects of various PLGA nano-formulations on reducing these drawbacks under both in-vitro and in-vitro conditions in three separate tables. Overall, this study proposes two AmB-loaded PLGA with a 99% reduction in parasite load as promising nanoparticles for further studies.