RESUMO
The arrival of immunotherapy has revolutioned the management of patients with metastatic Merkel cell carcinoma (MCC). We conducted an observational, retrospective study of 14 cases treated with avelumab. The response rate was 57%: complete response was reached in 29% of patients, and partial responses in 29%. The drug proved effective in 83% (5/6) of the patients with a single metastatic site. However, the disease progressed in 75% (3/4) of the patients with bone metastases. PD1-L expression, MCC polyomavirus (MCPyV) positivity, and an impaired neutrophil-to-lypmhocyte ratio (NLR) could not be associated with responses to the therapy. Avelumab is an effective and safe drug for the management of advanced MCC, and its effectiveness appears to be impacted by the number and location of metastases.
RESUMO
The lethal and sublethal effects of the ecdysone agonist methoxyfenozide on the fall armyworm, Spodoptera frugiperda (J. E. Smith), were investigated by feeding a methoxyfenozide-treated diet to fifth instars until pupation in doses corresponding to the LC10 and LC25 for the compound. Larval mortality reached 8 percent and 26 percent in the low and high concentration groups, respectively, on the seventh day of the experiment. A progressive larval mortality of 12 percent for the LC10 and 60 percent for the LC25 was observed before pupation. Treated larvae exhibited lower pupal weights, higher pupal mortality, presence of deformed pupae, and more deformed adults than untreated larvae. The incorporation of methoxyfenozide into the diet had a significant effect on the timing of larval development. The development period for males and females was about seven days longer than the controls for both concentrations tested. In contrast, the compound affected neither pupae nor adult longevity. Finally, S. frugiperda adults that resulted from fifth instars treated with methoxyfenozide were not affected in their mean cumulative number of eggs laid per female (fecundity), nor percentages of eggs hatched (fertility), or the sex ratio. Our results suggest that the combination of lethal and sublethal effects of methoxyfenozide may have important implications for the population dynamics of the fall armyworm.
Assuntos
Animais , Feminino , Masculino , Hidrazinas/farmacologia , Hormônios Juvenis/farmacologia , Spodoptera/efeitos dos fármacos , Spodoptera/fisiologia , Fertilidade/efeitos dos fármacos , Hidrazinas/toxicidade , Hormônios Juvenis/toxicidade , Larva/efeitos dos fármacos , Controle de Pragas , Spodoptera/crescimento & desenvolvimentoRESUMO
Las pancreatitis agudas letales (P.A.L.) son anatomo-patologicamente necrotico-hemorragicas. Se acompanan de una mortalidad cercana al 100%. En un intento de obtener una terapeutica mas eficaz que disminuya la elevada mortalidad de estos pacientes, se analizan retrospectivamente las historias clinicas de 22 enfermos tratados por los autores
Assuntos
PancreatiteRESUMO
Se analizan retrospectivamente las historias clinicas de 22 pacientes portadores de pancreatitis agudas necrotico-hemorragicas (P.A.N.H.), del punto de vista clinico, anatomo -patologico y terapeutico. Se obtiene asi un criterio terapeutico que parece ser el mas efectivo en el tratamiento de las pancreatitis agudas letales (P.A.L.): el soporte multisistemico precoz, la nocion de sentido evolutivo de la enfermedad pancreatica y la conducta reseccionista temprana cuando la enfermedad esta localizada a la logia
Assuntos
PancreatiteRESUMO
La evisceracion terapeutica controlada es un procedimiento consistente en la colocacion de una malla sustitutiva del cierre parietal para conservar la pared en casos de reintervenciones sucesivas, peritonitis hipersepticas, evisceraciones en sujectos en situacion general precaria o en resecciones parietales por sepsis de superficie. Se presentan 23 casos tratados por los autores, destacando la baja incidencia de complicaciones, las indicaciones y tecnica y resultados