1.
Bioorg Med Chem Lett
; 19(17): 5233-6, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19643611
RESUMO
A convenient route to N-substituted bis-C-alkylamidines possessing antiplasmodial activity and their oxadiazolone and amidoxime prodrug candidates, is described. These three families of compounds were available after a key N-alkylation step of the parent oxadiazolone 1a. Testing of the three compound classes in vitro and in vivo is also presented.