Outcomes of an exercise program in patients with dorsal or volar midcarpal laxity: a cohort study of 213 patients.

PURPOSE: Describing the outcomes of an exercise program on wrist and hand function for patients with midcarpal instability (MCI). MATERIALS AND METHODS: This study has a prospective cohort design. Two hundred and thirteen patients with MCI were included. The intervention was a 3-month exercise program consisting of hand therapy and home exercises. The primary outcome was perceived wrist and hand function evaluated with the Patient-Rated Wrist/Hand Evaluation (PRWHE) three months after treatment onset. Secondary outcomes were conversion to surgery, pain, and satisfaction with treatment results. RESULTS: PRWHE total scores improved from 51 ± 19 (mean ± SD) to 33 ± 24 at 3 months (95% CI: 36-30, p < 0.001). All visual analog scales for pain demonstrated clinically relevant improvements at 6 weeks and 3 months (p < 0.001). At 3 months, 81% of the participants would undergo the treatment again. After a median follow-up of 2.8 years, 46 patients (22%) converted to surgery. CONCLUSIONS: We found clinically relevant improvements in hand and wrist function and pain. Most participants would undergo treatment again and 78% of the participants did not convert to surgery. Hence, non-invasive treatment should be the primary treatment choice for patients with MCI.

Midcarpal instability (MCI) is a disabling condition and treatment options are limited.Patients with MCI can benefit from an exercise program aiming to improve the strength and coordination of the wrist muscles.Participants improved in hand/wrist function and 78% did not convert to surgery.Non-invasive treatment should be the primary treatment choice for these patients.

SMoC-Wrist: a sensorimotor control-based exercise program for patients with chronic wrist pain.

STUDY DESIGN: This is a narrative review. INTRODUCTION: Chronic wrist pain is a common disorder that can lead to considerable disability in performing activities in daily living and at work. Patients with nonspecific chronic wrist pain are regularly referred to a physiotherapist/hand therapist. Immobilization, avoiding excessive wrist load, steroid injections, and various physical therapy methods predominantly focus on the pain itself. However, these methods often do not result in a satisfactory long-term pain relief. PURPOSE OF THE STUDY: In this article, we will describe the principles behind and content of a sensorimotor control-based exercise program as introduced by Videler et al., modified and substantiated by current insights into sensorimotor control training and wrist kinetics. METHODS: Both structure and content of the modified exercise program (SMoC-wrist) are substantiated by recent scientific literature. RESULTS: A clear 4-level exercise model based on sensorimotor principles is presented, that is, proprioceptive level, conscious static/isometric level, conscious dynamic level, and unconscious dynamic level. The content of each level and the transition toward the next level are described in detail. DISCUSSION: Besides the substantiation of the exercise program, possible outcome measures for joint position sense and kinesthesia of the wrist are discussed. CONCLUSION: We modified and substantiated a widely used exercise program for patients with nonspecific chronic wrist pain based on recent insights into sensorimotor control principles and wrist kinematics. The presented exercise program (SMoC-wrist) is not primarily focused on reducing pain but on functional reeducation and strengthening of the neuromusculoskeletal system on the basis of sensorimotor control principles.

Tripod pinch strength and thumb opposition are the major determinants of manual dexterity in Charcot-Marie-Tooth disease type 1A.

BACKGROUND: Clinical features of Charcot-Marie-Tooth disease type 1A (CMT1A) include slowly progressive distal muscle weakness, atrophy and sensory loss. Upper-limb involvement results in reduced manual dexterity interfering with the execution of daily activities. OBJECTIVE: To identify which hand function impairments are determinants of manual dexterity in CMT1A. METHODS: In a cross-sectional, observational study, hand function (strength, mobility and sensory function) and manual dexterity (Sollerman hand function test) were evaluated in adults with CMT1A. Multiple linear regression analysis was used to determine the independent contribution of hand function variables on manual dexterity. Multifocal motor neuropathy (MMN) patients were chosen as a reference group with only motor impairments. RESULTS: Forty-nine proven CMT1A patients (21 males, mean age 47+/-12) and 15 MMN patients (12 males, mean age 54+/-8) were studied. Hand strength, mobility and sensory functions were impaired in CMT1A compared with normal values. Limited manual dexterity was found in 94% of the CMT1A patients. From the investigated determinants (age, gender, grip and pinch strength, joint mobility, thumb opposition, touch, discrimination and vibration sense), tripod pinch strength, thumb opposition and, to a lesser degree, vibration sense were independently associated with manual dexterity (69% explained variance). Tripod pinch strength was also most strongly associated with manual dexterity in MMN. CONCLUSIONS: Tripod pinch strength and thumb opposition are major determinants of manual dexterity in CMT1A and should therefore be the focus of intervention strategies that aim to preserve or enhance manual dexterity in CMT1A.

Limited upper limb functioning has impact on restrictions in participation and autonomy of patients with hereditary motor and sensory neuropathy 1a.

OBJECTIVE: To evaluate upper limb functioning, restrictions on participation and the independent contribution of upper and lower limb disability to participation in hereditary motor and sensory neuropathy 1a. DESIGN: Descriptive cross-sectional study. SUBJECTS: Forty-nine patients with hereditary motor and sensory neuropathy 1a. METHODS: Perceived upper limb functioning was evaluated using the Michigan Hand Outcomes Questionnaire and participation restrictions with the Impact on Participation and Autonomy Questionnaire. Upper and lower limb domains of Guy's Neurological Disability Scale were used to determine their impact on participation restrictions. RESULTS: Limitations in upper limb functioning were perceived by 98% of the patients. Median scores ranged between 70 points for overall hand function and 100 points for aesthetics (scale 0-100). Patients were least satisfied with dominant hand performance. Most patients (46-78%) reported their participation to be sufficient. Restrictions were reported in the domains work, family roles, and autonomy outdoors. Minor problems with restricted participation were indicated by 22-55%, severe problems by 2-12%. Upper limb functioning correlated significantly with all participation subscales. Upper limb disability was independently associated with participation restrictions, whereas lower limb disability was not. CONCLUSION: Limitations in upper limb functioning were perceived by the majority of patients with hereditary motor and sensory neuropathy 1a and strongly related to restricted participation.

Manual dexterity in hereditary motor and sensory neuropathy type 1a: severity of limitations and feasibility and reliability of two assessment instruments.

OBJECTIVE: To assess the prevalence and significance of impaired manual dexterity in hereditary motor and sensory neuropathy type 1a (HMSN 1a), with the Sollerman hand function and the Functional Dexterity test, and compare the reliability and agreement of the tests. DESIGN: Descriptive cross-sectional study. SUBJECTS: Forty-nine subjects with HMSN 1a. RESULTS: Forty-six (94%) subjects had an abnormal Sollerman sum score (< 80) for the dominant hand. The most difficult subtests required finger grips such as pulp, tripod and lateral pinches. Dexterity scores of both hands were categorized as "moderately functional". Test-retest reliability was excellent for the Sollerman test, with intraclass correlation coefficients between 0.98 and 0.99 (95% confidence interval (CI) 0.97-0.99), and good for Functional Dexterity test scores with correlation coefficients between 0.83 and 0.95 (95% CI. 71-0.97). The 95% limits of agreement between Sollerman tests showed that differences greater than 3 points can be interpreted as a change in dexterity. The Functional Dexterity test limits were wide. CONCLUSION: Impaired manual dexterity is common among subjects with HMSN 1a, stressing that the evaluation of dexterity is an essential element of the functional assessment. Both tests are able to detect impaired manual performance in HMSN 1a. For monitoring of disease progression and the effects of treatment programmes the Sollerman test is most suitable.

Manual dexterity and related functional limitations in hereditary motor and sensory neuropathy. An explorative study.

PURPOSE: To explore impairments in manual dexterity and perceived limitations in upper extremity-related activities in subjects with Hereditary Motor and Sensory Neuropathy (HMSN). METHOD: Cross-sectional study of 20 HMSN subjects. Manual dexterity was assessed using the Jebsen test of hand function. Perceived limitations were assessed using the Rehabilitation Activities Profile (RAP) and the Disabilities of Arm, Shoulder and Hand questionnaire (DASH). RESULTS: Impaired manual dexterity was found in four out of seven Jebsen sub-tests. Turning over cards, lifting large light and large heavy objects were most impaired, as reflected by median z scores of 5.7, 12.0 and 16.9, respectively. Perceived limitations, as reflected by median and percentile (P25; P75) sum-scores, were 7.5 (3; 11.7) for the RAP domains of personal care (scale 0-69) and 6.0 (1.25; 15.5) for the domains of occupation (scale 0-42). The median (P25; P75) DASH score (scale 0-100) was 13.3 (2.7; 48.1). Jebsen test scores were significantly associated with RAP and DASH scores. CONCLUSIONS: Manual dexterity of HMSN subjects, especially requiring the manipulation of flat and of large objects, was impaired and associated with the amount of perceived limitations in upper extremity function. Major limitations were perceived in activities related to upper extremity function by 25% of HMSN subjects. Measurement of manual dexterity and perceived limitations should be incorporated into the evaluation and treatment of HMSN subjects.

Hand strength and fatigue in patients with hereditary motor and sensory neuropathy (types I and II).

OBJECTIVES: To compare maximal isometric hand strength and fatigue between subjects with hereditary motor and sensory neuropathy (HMSN) and healthy controls and to test the reproducibility of handgrip strength (peak force of handgrip [PFgrip]) and fatigue. DESIGN: PFgrip and the decline in PFgrip during 3 sets of 15 contractions were compared. SETTING: University hospital in The Netherlands. PARTICIPANTS: Twenty subjects with HMSN and 20 age- and sex-matched healthy controls; 15 healthy subjects for the reproducibility part of the study. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: PFgrip and the decline in PFgrip were compared by using a digital handgrip dynamometer. Two-point and lateral pinch measurements of subjects with HMSN were standardized against reference values. Reproducibility measurements were performed on 15 healthy subjects on 2 separate occasions within a 1-week interval. RESULTS: PFgrip was significantly lower in the HMSN subjects compared with controls (P<.05). Pinch measurements also showed a large variance from average normal performance. No significant difference was found in the decline in percentage of PFgrip. Reproducibility was excellent for PFgrip (intraclass correlation coefficient [ICC]=.98; 95% confidence interval [CI],.95-.99) but poor for fatigue (ICC=.62; 95% CI,.20-.85). CONCLUSION: PFgrip and 2-point and lateral pinch in HMSN subjects were significantly reduced compared with healthy controls. Our findings indicated that the rate of decline of PFgrip during effort does not vary between groups.