RESUMO
Hormones are known to influence various body systems that include skeletal, cardiac, digestive, excretory, and immune systems. Emerging investigations suggest the key role played by secretions of endocrine glands in immune cell differentiation, proliferation, activation, and memory attributes of the immune system. The link between steroid hormones such as glucocorticoids and inflammation is widely known. However, the role of peptide hormones and amino acid derivatives such as growth and thyroid hormones, prolactin, dopamine, and thymopoietin in regulating the functioning of the immune system remains unclear. Here, we reviewed the findings pertinent to the functional role of hormone-immune interactions in health and disease and proposed perspective directions for translational research in the field.
Assuntos
Doenças do Sistema Endócrino/metabolismo , Sistema Endócrino/metabolismo , Hormônio do Crescimento/metabolismo , Doenças do Sistema Imunitário/metabolismo , Sistema Imunitário/metabolismo , Prolactina/metabolismo , Timócitos/metabolismo , Animais , Comunicação Celular , Citocinas/genética , Citocinas/imunologia , Citocinas/metabolismo , Dopamina/genética , Dopamina/imunologia , Dopamina/metabolismo , Sistema Endócrino/citologia , Sistema Endócrino/imunologia , Doenças do Sistema Endócrino/genética , Doenças do Sistema Endócrino/imunologia , Doenças do Sistema Endócrino/patologia , Glucocorticoides/genética , Glucocorticoides/imunologia , Glucocorticoides/metabolismo , Hormônio do Crescimento/genética , Hormônio do Crescimento/imunologia , Humanos , Sistema Imunitário/citologia , Sistema Imunitário/imunologia , Doenças do Sistema Imunitário/genética , Doenças do Sistema Imunitário/imunologia , Doenças do Sistema Imunitário/patologia , Lactotrofos/citologia , Lactotrofos/imunologia , Lactotrofos/metabolismo , Prolactina/genética , Prolactina/imunologia , Receptores Dopaminérgicos/genética , Receptores Dopaminérgicos/imunologia , Receptores Dopaminérgicos/metabolismo , Somatotrofos/citologia , Somatotrofos/imunologia , Somatotrofos/metabolismo , Timócitos/citologia , Timócitos/imunologia , Hormônios Tireóideos/genética , Hormônios Tireóideos/imunologia , Hormônios Tireóideos/metabolismoRESUMO
BACKGROUND: Natural products have continually played an important role in drug discovery because it serves as active principles in drugs as well as templates for synthesis of new drugs. Cayratia trifolia (L.) is a medicinal plant, which has been reported to have antiviral, antibacterial, antiprotozoal, hypoglycemic, anticancer and diuretic activities. OBJECTIVE: Therefore, the objective of this study is to isolate and identify the natural compound from the ethanolic extract of Cayratia trifolia (L.) and to predict the Absorption, Distribution, Metabolism and Excretion (ADME) properties of isolated natural compound. MATERIALS AND METHODS: Column chromatography and thin layer chromatography were used to isolate the natural compound and Fourier-transform infrared (FTIR) spectroscopy was used to predict the functional groups present in the isolated natural compound. The structural characterization studies were functionally carried out using (1)H, (13)C, two-dimensional nuclear magnetic resonance (NMR) and mass spectrometry methods. RESULTS: FTIR showed that, the groups of OH, C-H, C = C may be present in the isolated natural compound. (1)H, (13)C, two-dimensional NMR and mass spectrometry data suggests that the isolated natural compound probably like linoleic acid. In silico ADME properties, prediction of the compound was under acceptable range. CONCLUSION: Based on the results, it can be concluded that, the isolated natural compound of linoleic acid that has been exhibited good medicinal properties.