MOFs with Open Metal(III) Sites for the Environmental Capture of Polar Volatile Organic Compounds.

Metal-Organic Frameworks (MOFs) with open metal sites (OMS) interact strongly with a range of polar gases/vapors. However, under ambient conditions, their selective adsorption is generally impaired due to a high OMS affinity to water. This led previously to the privilege selection of hydrophobic MOFs for the selective capture/detection of volatile organic compounds (VOCs). Herein, we show that this paradigm is challenged by metal(III) polycarboxylates MOFs, bearing a high concentration of OMS, as MIL-100(Fe), enabling the selective capture of polar VOCs even in the presence of water. With experimental and computational tools, including single-component gravimetric and dynamic mixture adsorption measurements, in situ infrared (IR) spectroscopy and Density Functional Theory calculations we reveal that this adsorption mechanism involves a direct coordination of the VOC on the OMS, associated with an interaction energy that exceeds that of water. Hence, MOFs with OMS are demonstrated to be of interest for air purification purposes.

Effective Degradation of Novichok Nerve Agents by the Zirconium Metal-Organic Framework MOF-808.

Novichoks are a novel class of nerve agents (also referred to as the A-series) that were employed in several poisonings over the last few years. This calls for the development of novel countermeasures that can be applied in protective concepts (e.g., protective clothing) or in decontamination methods. The Zr metal-organic framework MOF-808 has recently emerged as a promising catalyst in the hydrolysis of the V- and G-series of nerve agents as well as their simulants. In this paper, we report a detailed study of the degradation of three Novichok agents by MOF-808 in buffers with varying pH. MOF-808 is revealed to be a highly efficient and regenerable catalyst for Novichok agent hydrolysis under basic conditions. In contrast to the V- and G-series of agents, degradation of Novichoks is demonstrated to proceed in two consecutive hydrolysis steps. Initial extremely rapid P-F bond breaking is followed by MOF-catalyzed removal of the amidine group from the intermediate product. The intermediate thus acted as a competitive substrate that was rate-determining for the whole two-step degradation route. Under acidic conditions, the amidine group in Novichok A-230 is more rapidly hydrolyzed than the P-F bond, giving rise to another moderately toxic intermediate. This intermediate could in turn be efficiently hydrolyzed by MOF-808 under basic conditions. These experimental observations were corroborated by density functional theory calculations to shed light on molecular mechanisms.