RESUMO
Pathogenic mechanisms of B-cell lymphoproliferative disorders in chronic hepatitis C virus (HCV) infection are unclear. We studied t(14;18) translocation by polymerase chain reaction in peripheral blood mononuclear cells from 50 patients with HCV-related liver disease (group A), 7 with mixed cryoglobulinemia syndrome (group B), 55 with HCV-negative liver disease (group C), and 30 with HCV-negative chronic rheumatic disorders or chronic infection by nonhepatotropic agents (group D). T(14;18) was significantly more frequent in group A (13/50 patients = 26 %) and group B (5/7 = 71.4%) patients than in group C (1/55 = 3.6%) and group D (1/30 = 3.3%) ones. Immunoblot analysis showed bcl-2 over-expression in all t(14;18)-positive samples. In group A, 10/13 (77%) patients with t(14;18) and 13/37 (35%) without t(14;18) had serum cryoglobulins in the absence of mixed cryoglobulinemia symptoms (P <.05). These data indicate that t(14;18) and bcl-2 over-expression in lymphoid cells are frequent in chronic HCV infection and suggest that this event may contribute to the pathogenesis of HCV-related lymphoproliferative disorders.
Assuntos
Cromossomos Humanos Par 14/genética , Cromossomos Humanos Par 18/genética , Hepatite C Crônica/genética , Translocação Genética/genética , Idoso , Idoso de 80 Anos ou mais , Doença Crônica , Crioglobulinemia/sangue , Crioglobulinemia/genética , Crioglobulinas/análise , Feminino , Frequência do Gene , Hepatite C Crônica/sangue , Hepatite C Crônica/complicações , Humanos , Infecções/sangue , Infecções/genética , Hepatopatias/sangue , Hepatopatias/genética , Hepatopatias/virologia , Masculino , Pessoa de Meia-Idade , Monócitos/fisiologia , Proteínas Proto-Oncogênicas c-bcl-2/sangue , Doenças Reumáticas/sangue , Doenças Reumáticas/genéticaRESUMO
We present three cases of colonic lipomas; the first lipoma was removed endoscopically, the other two lesions were left in situ following recognition of their benign natures. We recommend that lesions of the colon recognized as lipomas and found incidentally be left alone.