(S)-(+)-1-(4-Bromo-phen-yl)-N-[(4-methoxyphen-yl)methyl-idene]ethyl-amine and bis-{(S)-(+)-1-(4-bromo-phen-yl)-N-[(4-methoxyphen-yl)methyl-idene]ethyl-amine-κN}di-chlorido-palladium(II).

The (S)-(+)-1-(4-bromo-phen-yl)-N-[(4-methoxyphen-yl)methyl-idene]ethyl-amine ligand, C16H16BrNO, (I), was synthesized through the reaction of 4-meth-oxy-anisaldehyde with (S)-(-)-1-(4-bromo-phen-yl)ethyl-amine. It crystallizes in the ortho-rhom-bic space group P212121 belonging to the Sohncke group, featuring a single mol-ecule in the asymmetric unit. The refinement converged successfully, achieving an R factor of 0.0508. The PdII com-plex bis-{(S)-(+)-1-(4-bromo-phen-yl)-N-[(4-methoxyphen-yl)methyl-idene]ethyl-amine-κN}di-chlorido-pal-ladium(II), [PdCl2(C16H16BrNO)2], (II), crystallizes in the monoclinic space group P21 belonging to the Sohncke group, with two mol-ecules in the asymmetric unit. The central atom is tetra-coordinated by two N atoms and two Cl atoms, resulting in a square-planar configuration. The imine moieties exhibit a trans configuration around the PdII centre, with average Cl-Pd-N angles of approximately 89.95 and 90°. The average distances within the palladium com-plex for the two mol-ecules are ∼2.031 Šfor Pd-N and ∼2.309 Šfor Pd-Cl.

X-ray structure analysis of symmetrically substituted 1,1'-diformyl-ruthenocene.

1,1'-Di-formyl-ruthenocene, [Ru(C6H5O)2], crystallizes in the ortho-rhom-bic system in the P212121 space group at room temperature. There are two crystallographically independent mol-ecules in the asymmetric unit. The cyclo-penta-dienyl rings have eclipsed configuration. The mol-ecules self-assemble in a two-dimensional structure by C-H⋯O and C-H⋯π inter-actions with cisoid relative orientations of the two formyl groups. The crystal studied was refined as an inversion twin.

Colombian study to assess the use of noninvasive determination of the endothelium-mediated vasodilation (CANDEV) II: does location of the occlusion device affects the accuracy of the diagnosis?

Endothelial dysfunction (ED), which is often evaluated by flow-mediated vasodilation (FMV) in the brachial artery, has been postulated as a predictor of cardiac events. Although the upper and forearm location of the occlusion device have been used for FMV evaluation, currently there is no consensus whether they provide the same information. The main goal of this study was to evaluate if both techniques have the same accuracy to differentiate subjects with and without cardiovascular risk factors (CRFs). A cross-sectional study in 124 subjects was performed. The volunteers were divided in two groups: 62 subjects (20 women and 42 men) with at least one CRF and 62 (20 women and 42 men) healthy subjects without CRFs. FMV measurements using the cuff in the upper arm and forearm with intervals of 30 min were taken. In all subjects, %FMV with the cuff located in the upper arm was 10.13 +/- 4.5 and 9.8 +/- 4.1 with the cuff located below the elbow. In healthy subjects without CRFs the %FMV in the upper arm was 12.19 +/- 4.0 versus 12.31 +/- 3.4 in the upper forearm, in CRF subjects it was 8.08 +/- 4.0 vs 7.29 +/- 3.2., respectively. FMV was not affected by the location of the cuff in maintaining the test ability and accuracy to differentiate subjects with and without CRFs.

Nimesulide betadex en el tratamiento de pacientes con dorsolumbalgia de origen traumático / Betadex nimesulide in the treatment of patient with low backpain of traumatic origin

La dorsolumbalgia es una patología frecuente e incapacitante, cuyo tratamiento más importante constituye el alivio del dolor mediante el uso de AINES. A los efectos del presente estudio, se evaluaron 90 pacientes con diagnóstico de dorsolumbalgia mecánica, a los cuales se le suministró nimesulide betadex 100 mg dos veces al día durante 10 a 15 días, se evaluaron mediante VAS (0-10 cm) y escala funcional a los tiempos 0-48 h, 5-10 y 15 días. Después de 48 horas de tratamiento se produjo un cambio significativo en la EVA 7.42 a 5.15 (p<0.000) con cambios similares a los 5 y 10 días. Una evolución similar mostró la escala funcional. Los efectos adversos ocurrieron en el 6.6 por ciento de los pacientes, y estos fueron: epistralgia (2), dispepsia (1), acidez (2), reacción alérgica (1), en este último paciente fue necesario suspender el tratamiento. Nimesulide betadex es efectivo, rápido y bien tolerado en el alivio de los pacientes con dorsolumbalgia mecánica

Estudios neuroepidemiológicos colombianos empleando el protocolo de la OMS / Colombian neuroepidemiological studies using the WHO protocol

Empleando el protocolo para estudios neuroepidemiológicos de la Organización Mundial de la Salud, se realizaron seis estudios pilotos de campo de corte transversal en poblaciones urbanas y rurales colombianas para determinar la prevalencia de las principales enfermedades neurológicas. Las investigaciones contemplaron una muestra de 9.800 habitantes y fueron estudiados entre 1983 y 1991. Se utilizaron definiciones y criterios diagnósticos establecidos por la OMS y se utilizó una metodología similar a la empleada en el estudio piloto pionero colombiano de Girón. La prevalencia de las enfermedades neurológicas (por 1.000 habitantes) mostró los siguientes resultados: 1. Migraña:100; 2. Epilepsia:13,2; 3. Neuropatías Perisféricas:9,0; 4. Retardo Mental:7,4; 5. Enfermedad cerebrovscular:6,7; 6. Enfermedades extrapiramidales:6,6. De las enfermedades no neurológicas llamó la atención el Síncope con una prevalencia de 7,1 o/oo. Los resultados anteriores demuestran una alta prevalencia de Migraña, Epilepsia, Neuropatías Perisféricas y Retardo Mental principalmente, que deben confirmarse mediante estudios con un protocolo similar en poblaciones mayores