RESUMO
The sole universally recognized diagnostic criterion for the affection of central nervous system by immunodeficiency virus is AIDS-dementia complex. Its main pathognomonic feature is progressive intellect failure although most patients do not experience intellect deficit. Instead, they present with other disorders in the central nervous system. This article focuses on their early diagnosis.
Assuntos
Anticorpos Anti-HIV/análise , Infecções por HIV/complicações , HIV/imunologia , Doenças do Sistema Nervoso/epidemiologia , Progressão da Doença , Infecções por HIV/virologia , Humanos , Incidência , Inteligência , Doenças do Sistema Nervoso/diagnóstico , Doenças do Sistema Nervoso/etiologia , Prevalência , Testes Psicológicos , Federação Russa/epidemiologiaRESUMO
AIM: To ascertain the role of high antibodies (Ab) titers to microsomal antigen (MA) of the thyroid in clinical manifestations of cytopenic syndromes. MATERIAL AND METHODS: Clinical data are presented on 144 patients with depressed hemopoiesis having different levels of thyroid Aab. RESULTS: When the titer was significantly elevated (41% patients with immune cytopenias), hematological malignancies run with recurrences, remission is rare. Treatment of the thyroid pathology improves hematological indices in some cases though does not reduce titers of Ab thyroid MA. CONCLUSION: Detection of autoimmune pathology of the thyroid is necessary not only for specification of the concurrent process diagnosis but also for initiation of adequate combined treatment.
Assuntos
Autoanticorpos/análise , Autoantígenos/imunologia , Doenças Autoimunes/imunologia , Doenças Hematológicas/imunologia , Hematopoese , Iodeto Peroxidase/imunologia , Proteínas de Ligação ao Ferro/imunologia , Glândula Tireoide/imunologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Doenças Autoimunes/sangue , Cobamidas/deficiência , Feminino , Doenças Hematológicas/sangue , Humanos , Masculino , Pessoa de Meia-Idade , Neutropenia/sangue , Neutropenia/imunologia , Púrpura Trombocitopênica Idiopática/sangue , Púrpura Trombocitopênica Idiopática/imunologia , Tireoidite Autoimune/sangue , Tireoidite Autoimune/imunologiaRESUMO
AIM: To study the level of thyroid antibodies (TAB) in blood diseases. MATERIAL AND METHODS: TAB levels dynamics was studied in 413 patients with hematological diseases. RESULTS: Increased incidence of cases with high Ab titer to thyroid microsomal antigen was found. High and moderate titers were revealed in 33% of all examinees, including 41%, 22%, 32% and 29% among patients with immune cytopenia, chronic lymphoid leukemia, generalized mature-cell lymphoma and myeloproliferative diseases, respectively. These high and moderate titers were rather stable. In 15% patients Ab were elevated insignificantly, this rise being unstable. CONCLUSION: Stable high titers of antibodies to thyroid antigens point to increased incidence rates of concomitant autoimmune hyroiditis in patients with blood diseases.