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1.
Thorax ; 75(4): 298-305, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32094154

RESUMO

BACKGROUND: Hospitalisation with severe lower respiratory tract infection (LRTI) in early childhood is associated with ongoing respiratory symptoms and possible later development of bronchiectasis. We aimed to reduce this intermediate respiratory morbidity with a community intervention programme at time of discharge. METHODS: This randomised, controlled, single-blind trial enrolled children aged <2 years hospitalised for severe LRTI to 'intervention' or 'control'. Intervention was three monthly community clinics treating wet cough with prolonged antibiotics referring non-responders. All other health issues were addressed, and health resilience behaviours were encouraged, with referrals for housing or smoking concerns. Controls followed the usual pathway of parent-initiated healthcare access. After 24 months, all children were assessed by a paediatrician blinded to randomisation for primary outcomes of wet cough, abnormal examination (crackles or clubbing) or chest X-ray Brasfield score ≤22. FINDINGS: 400 children (203 intervention, 197 control) were enrolled in 2011-2012; mean age 6.9 months, 230 boys, 87% Maori/Pasifika ethnicity and 83% from the most deprived quintile. Final assessment of 321/400 (80.3%) showed no differences in presence of wet cough (33.9% intervention, 36.5% controls, relative risk (RR) 0.93, 95% CI 0.69 to 1.25), abnormal examination (21.7% intervention, 23.9% controls, RR 0.92, 95% CI 0.61 to 1.38) or Brasfield score ≤22 (32.4% intervention, 37.9% control, RR 0.85, 95% CI 0.63 to 1.17). Twelve (all intervention) were diagnosed with bronchiectasis within this timeframe. INTERPRETATION: We have identified children at high risk of ongoing respiratory disease following hospital admission with severe LRTI in whom this intervention programme did not change outcomes over 2 years. TRIAL REGISTRATION NUMBER: ACTRN12610001095055.


Assuntos
Bronquiectasia/prevenção & controle , Bronquiolite/tratamento farmacológico , Cuidadores/organização & administração , Serviços de Saúde Comunitária/organização & administração , Hospitalização/estatística & dados numéricos , Pneumonia Bacteriana/tratamento farmacológico , Antibacterianos/uso terapêutico , Bronquiectasia/epidemiologia , Bronquiolite/diagnóstico , Feminino , Seguimentos , Humanos , Lactente , Masculino , Nova Zelândia , Avaliação de Resultados em Cuidados de Saúde , Pais , Pneumonia Bacteriana/diagnóstico , Prognóstico , Estudos Prospectivos , Medição de Risco , Índice de Gravidade de Doença , Método Simples-Cego , Fatores de Tempo
2.
J Paediatr Child Health ; 56(2): 244-251, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31355978

RESUMO

AIM: Staphylococcus aureus (SA) causes serious invasive disease in children. Large studies have measured the incidence of SA bacteraemia, but there is less information on the total burden of community-acquired invasive SA (iSA) in children. METHODS: A retrospective, cross-sectional analysis of Auckland resident children aged 0-14 years who were hospitalised with iSA between 2011 and 2015 was performed. Laboratory databases and SA-related international classification of diseases 10 discharge codes were searched to identify community-onset cases with SA isolated from a normally sterile site. Clinical records and coroner's reports were reviewed to determine clinical syndromes and exclude nosocomial infections. RESULTS: A total of 295 children with iSA were identified. The average annual incidence of iSA was 18.6 per 100 000 - for Pacific populations 44.3 per 100 000, Maori 24.3 per 100 000 and New Zealand European and other 8.8 per 100 000; 68% had bacteraemia. The incidence of iSA for Pacific infants was 10 times greater than non-Maori/non-Pacific (113.4/100 000 population vs. 11.8/100 000). Multivariate analysis found a higher risk of admission in Pacific children, males and those living in areas of high deprivation. Thirty-two patients (10.8%) were admitted to the intensive care unit; risk was higher in infants, Pacific children and those with respiratory infection (Relative Risk (RR) 12.2, 95% confidence interval (CI) 5.7-26.4) and multifocal (RR 6.9, 95% CI 3.4-13.8) and endovascular disease (RR 8.9, 95% CI 3.9-20.6). All deaths (n = 7) had respiratory infections, and four were patients <1 year of age. CONCLUSIONS: Studies investigating SA bacteraemia alone significantly underestimate the total burden of iSA disease. There are marked ethnic and socio-economic disparities in iSA disease among Auckland children. Pacific infants are at the highest risk.


Assuntos
Efeitos Psicossociais da Doença , Staphylococcus aureus , Adolescente , Criança , Pré-Escolar , Estudos Transversais , Humanos , Incidência , Lactente , Recém-Nascido , Masculino , Nova Zelândia/epidemiologia , Estudos Retrospectivos , Fatores de Risco
3.
J Paediatr Child Health ; 55(6): 652-658, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30311280

RESUMO

AIM: A retrospective Auckland-wide (total population approximately 1.4 million) study of hospital admissions from 2007 to 2015 was conducted to assess trends in admissions for acute post-streptococcal glomerulonephritis (APSGN) in children aged 0-14 years. METHODS: International Statistical Classification of Diseases (ICD10) discharge codes were used to identify potential cases of APSGN, and electronic clinical records and laboratory data were compared with established case definitions for definite or probable APSGN. RESULTS: A total of 430 cases of APSGN were identified (definite n = 337, probable n = 93), with a mean annual incidence of 15.2/100 000 (95% confidence interval (CI) 14.9-15.6). Incidence (0-14 years) was 17 times higher in Pacific peoples (50.2/100 000, 95% CI 48.6-51.8) and almost 7 times higher in Maori (19.6/100 000, 95% CI 18.6-20.7) than European/other populations (2.9/100 000, 95% CI 2.7-3.1). Multivariate analysis found ethnicity, deprivation, male gender, age (peak 3-8 years) and season (summer/autumn) to be associated with admission risk. Admission rates showed a significant change of -9.0% (95% CI -10.4, 7.4%) per year, with 2011 being an exception. Low C3 complement, hypertension, elevated streptococcal titres, oedema and heavy proteinuria were present in 94, 65, 67, 52 and 49% of cases, respectively. Relying on ICD10 codes without further review of clinical notes would result in an overcount of cases by 25%. CONCLUSIONS: There is severe disparity in APSGN admission rates, with a disproportionate burden of disease for Pacific and Maori children and those living in deprived circumstances. Rates trended downward from 2007 to 2015.


Assuntos
Glomerulonefrite/epidemiologia , Disparidades nos Níveis de Saúde , Havaiano Nativo ou Outro Ilhéu do Pacífico , Admissão do Paciente/tendências , Infecções Estreptocócicas/complicações , Doença Aguda , Adolescente , Criança , Pré-Escolar , Feminino , Glomerulonefrite/microbiologia , Humanos , Incidência , Lactente , Recém-Nascido , Masculino , Nova Zelândia/epidemiologia , Estudos Retrospectivos , Fatores de Risco
4.
J Paediatr Child Health ; 54(4): 377-382, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29125216

RESUMO

AIM: Sudden unexpected death in infancy (SUDI) rates for Maori and Pacific infants remain higher than for other ethnic groups in New Zealand and bed-sharing is a major risk factor when there is smoking exposure in pregnancy. Sleep space programmes of education and Pepi-Pod baby beds require evaluation. METHODS: Two hundred and forty Maori and Pacific women and infants were randomised 1:1, to the Pepi-Pod sleep space programme, or to a control group with 'usual care'. When infants were under 2 weeks of age, baseline interviews occurred, followed up by interviews at 2 and 4 months of age to assess safe sleep knowledge, infant care practices and Pepi-Pod use and acceptability. All participants were offered a New Zealand Standard approved portable cot. RESULTS: At baseline, 25% of babies did not have a baby bed. Knowledge of smoking and bed-sharing as SUDI risks improved at follow-up in both groups. One quarter regularly bed-shared at follow-up in both groups. Intention to bed-share was a strong predictor of subsequent behaviour. Pepi-Pods were regularly used by 46% at 2 months and 16% at 4 months follow-up. CONCLUSIONS: Bed-sharing and knowledge improvement were similar irrespective of group. It is likely that the impact of the intervention was reduced because the control group received better support than 'usual care' and all participants had a baby bed. New Zealand SUDI rates have declined since sleep space programmes have been available. Sleep space programmes should be prioritised for those with modifiable SUDI risk.


Assuntos
Leitos , Educação em Saúde , Conhecimentos, Atitudes e Prática em Saúde , Cuidado do Lactente , Morte Súbita do Lactente/prevenção & controle , Aleitamento Materno/estatística & dados numéricos , Humanos , Lactente , Havaiano Nativo ou Outro Ilhéu do Pacífico , Nova Zelândia , Pais , Comportamento de Redução do Risco , Fumar , Morte Súbita do Lactente/etnologia
5.
J Paediatr Child Health ; 53(6): 551-555, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28430397

RESUMO

AIM: To describe respiratory virus detection in children under 2 years of age in a population admitted with lower respiratory infection and to assess correlation with measures of severity. METHODS: Nasopharyngeal aspirates from infants admitted with lower respiratory tract infection (n = 1645) over a 3-year time period were tested by polymerase chain reaction. We collected epidemiological and clinical data on all children. We assessed the correlation of presence of virus with length of hospital stay, intensive care admission and consolidation on chest X-ray. RESULTS: Of the children admitted 34% were Maori, 43% Pacific and 75% lived in areas in the bottom quintile for socio-economic deprivation. A virus was found in 94% of those tested including 30% with multiple viruses. Picornavirus was present in 59% including 34% as the sole virus. Respiratory syncytial virus was found in 39%. Virus co-detection was not associated with length of stay, chest X-ray changes or intensive care unit admission. CONCLUSION: In this disadvantaged predominately Maori and Pacific population, picornavirus is commonly found as a sole virus, respiratory syncytial virus is frequent but immunisation preventable influenza is infrequent. We did not find that co-detection of viruses was linked to severity.


Assuntos
Hospitalização/estatística & dados numéricos , Infecções por Picornaviridae/diagnóstico , Infecções por Vírus Respiratório Sincicial/diagnóstico , Vírus Sincicial Respiratório Humano/isolamento & purificação , Infecções Respiratórias/virologia , Fatores Etários , Pré-Escolar , Estudos de Coortes , Feminino , Hospitais Pediátricos , Humanos , Incidência , Lactente , Tempo de Internação , Masculino , Nova Zelândia/epidemiologia , Infecções por Picornaviridae/epidemiologia , Prognóstico , Infecções por Vírus Respiratório Sincicial/epidemiologia , Infecções Respiratórias/diagnóstico , Infecções Respiratórias/epidemiologia , Estudos Retrospectivos , Índice de Gravidade de Doença
6.
N Z Med J ; 129(1443): 77-83, 2016 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-27736855

RESUMO

Admissions for skin and soft-tissue infections have been increasing steadily in children and in the general population. Concerns have been raised recently about the increasing widespread use of topical fusidic acid and concurrent increase of fusidic acid-resistant Staphylococcus aureus. Fusidic acid resistance and methicillin resistant Staphylococcus aureus (MRSA) are both more prevalent in youngest age group (<5 year-olds) and particularly in the North island. In New Zealand, fusidic acid is recommended for treatment of minor impetigo and is the only fully-funded topical antibiotic. The evidence base for alternative treatment strategies for mild impetigo is limited. Most children with impetigo in the current Counties Manukau skin and sore throat schools programme received care with wound management with only a few requiring escalation. An upcoming randomised controlled trial comparing topical hydrogen peroxide cream, topical fusidic acid and wound management only (clean and cover) will help provide evidence about the effectiveness of alternative treatments in the New Zealand setting.


Assuntos
Antibacterianos/administração & dosagem , Ácido Fusídico/administração & dosagem , Impetigo/tratamento farmacológico , Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos , Infecções Estafilocócicas/epidemiologia , Administração Tópica , Adolescente , Criança , Pré-Escolar , Farmacorresistência Bacteriana , Humanos , Lactente , Recém-Nascido , Nova Zelândia , Infecções Estafilocócicas/tratamento farmacológico
7.
N Z Med J ; 126(1380): 27-38, 2013 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-24126747

RESUMO

BACKGROUND: Skin infection is the commonest medical cause of hospitalisation in school children. Disadvantaged children, usually Maori or Pacific, have high rates of preventable diseases. AIM: To improve access to early treatment for skin infections using nurse-led school clinics in South Auckland, including provision of antibiotics under delegated standing orders. METHOD: Evidence-based protocols for the recognition and treatment of skin sepsis were developed following a literature search. A training package was developed for health professionals involved and outcome data were collected from a pilot study in which the protocols were trialled. RESULTS: An algorithm for diagnosis of skin infections was adapted from Steer et al (Bull World Health Organ. 2009;87:173-9). Fusidic acid ointment was recommended as first-line treatment for localised impetigo. Twice daily oral cephalexin was recommended for extensive impetigo and cellulitis, for palatability and simplicity of dosing. Fifty-six episodes of skin infection received treatment under standing orders in the first 15 weeks of the pilot study. CONCLUSION: Robust evidence to determine optimal choice, dosage and duration of antibiotic therapy for skin sepsis in children is lacking. The algorithms described are consistent with available evidence and provide a pragmatic approach for use in registered nurse (RN)-led school clinics.


Assuntos
Protocolos Clínicos , Avaliação em Enfermagem , Serviços de Enfermagem Escolar , Dermatopatias Infecciosas/enfermagem , Adolescente , Algoritmos , Anti-Infecciosos/uso terapêutico , Criança , Pré-Escolar , Medicina Baseada em Evidências , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Nova Zelândia/epidemiologia , Projetos Piloto , Guias de Prática Clínica como Assunto , Prevalência , Dermatopatias Infecciosas/epidemiologia
8.
N Z Med J ; 126(1378): 26-35, 2013 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-24045313

RESUMO

AIM: To assess the change in admission rates for all Lower Respiratory Infection (LRI) including pneumonia for children resident in Counties Manukau District Health Board (CMDHB) with the introduction of the Pneumococcal Conjugate Vaccine 7 valent (PCV7) in June 2008. METHOD: National Minimum dataset ICD10 coded LRI admissions to any NZ hospital August 2001-July 2011 for children <2 year resident in CMDHB were analysed using Poisson regression, omitting 1 August 2008 to 31 July 2009, the first-year post vaccine introduction. RESULTS: Pneumonia but not bronchiolitis admissions have been declining since 2001. Pneumonia admissions decreased significantly after PCV7 introduction (incidence risk ratio (IRR) (95% CI) 1.51 (1.08-1.77), additional to the gradual decline since 2001. There was significant decline for Pacific children post PCV7 introduction IRR 1.70(1.39, 2.07) but not for Maori children, IRR 1.05 (0.78-1.40). Maori and Pacific children are at increased risk of admission with LRI compared to European children (relative risk (RR) (95%CI) 4.6 (4.3-5.0) and 5.0(3.7-5.3) respectively) as are those living in Decile 9, 10 compared with those from other deciles, RR 1.43 (1.36-1.50). CONCLUSION: The introduction of PCV7 is associated with reduced admissions for pneumonia in young children yet there has been less impact for Maori in CMDHB.


Assuntos
Admissão do Paciente/estatística & dados numéricos , Vacinas Pneumocócicas/administração & dosagem , Pneumonia/imunologia , Infecções Respiratórias/imunologia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Nova Zelândia/epidemiologia , Pneumonia/epidemiologia , Infecções Respiratórias/complicações , Medição de Risco , Vacinas Conjugadas/administração & dosagem
9.
N Z Med J ; 125(1367): 15-23, 2012 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-23321880

RESUMO

AIM: To describe household characteristics of admissions for lower respiratory tract infection (LRI) in children aged less than 2 years in Counties Manukau, South Auckland, New Zealand. METHODS: Prospective recruitment of all children aged less than 2 years admitted with a primary diagnosis of LRI from August to December 2007 with caregiver questionnaire. RESULTS: There were 580 admissions involving 465 children, 394 of whom had completed questionnaires (85% response rate). Sixty-four percent of admissions had a diagnosis of bronchiolitis and 26% of pneumonia. Relative risk of admission was 4.4 (95% CI 3.2-6.2) for Maori, 5.8 (4.4-7.9) for Pacific peoples compared with European/others and 3.1 (2.4-3.9) for the most deprived quintile compared with other quintiles. Longer total stay was more likely in those of younger age, who were premature or of Maori or Pacific ethnicity. Household characteristics demonstrate that 25% live with =7 other people, 33% live with 4 or more children, 65% of children are exposed to cigarette smoke and 27% use no form of heating. CONCLUSIONS: Among young children admitted with LRI there is a high rate of exposure to known avoidable risk factors such as smoking, lack of heating and large households in overcrowded conditions.


Assuntos
Características da Família , Infecções Respiratórias/epidemiologia , Aglomeração , Feminino , Hospitalização/estatística & dados numéricos , Temperatura Alta , Humanos , Lactente , Recém-Nascido , Tempo de Internação/estatística & dados numéricos , Masculino , Nova Zelândia/epidemiologia , Estudos Prospectivos , Análise de Regressão , Infecções Respiratórias/terapia , Fatores de Risco , Fumar/efeitos adversos , Fumar/epidemiologia , Inquéritos e Questionários
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