RESUMO
A number of optoacoustic (or photoacoustic) microscopy and mesoscopy techniques have successfully been employed for non-invasive tumor angiography. However, accurate rendering of tortuous and multidirectional neoplastic vessels is commonly hindered by the limited aperture size, narrow bandwidth and insufficient angular coverage of commercially available ultrasound transducers. We exploited the excellent flexibility and elasticity of a piezo polymer (PVDF) material to devise a fisheye-shape ultrasound detector with a high numerical aperture of 0.9, wide 1-30 MHz detection bandwidth and 27 mm diameter aperture suitable for imaging tumors of various size. We show theoretically and experimentally that the wide detector's view-angle and bandwidth are paramount for achieving a detailed visualization of the intricate arbitrarily-oriented neovasculature in experimental tumors. The developed approach is shown to be well adapted to the tasks of experimental oncology thus allows to better exploit the angiographic potential of optoacoustics.
RESUMO
The influence of background ultrasonic field on the ultimate dynamic strength of adhesive joints is studied using fracture mechanics analysis. Winkler foundation-type models are applied to describe the cohesion zone, and the incubation time fracture criterion is used. The challenging task is to study whether relatively weak ultrasound is able to decrease the threshold values of the external impact load depending on a joint model, such as an "elastic membrane" or "beam" approximation, and various boundary conditions at the ends. The specific task was to investigate the case of short pulse loading through application of time-dependent fracture criterion instead of the conventional principle of critical stress. Three different load cases, namely, step constant force, dynamic pulse, and their combination with ultrasonic vibrations, were also studied. The analytical solution to the problem demonstrates that background vibrations at certain frequencies can significantly decrease threshold values of fracture impact load. Specific calculations indicate that even a weak background sonic field is enough to cause a significant reduction in the threshold amplitude of a dynamic short pulse load. Additionally, non-monotonic dependency of threshold amplitude on pulse duration for weak background field was observed, which demonstrates the existence of optimal regimes of impact energy input. Moreover, this phenomenon does not depend on the way in which the beam edges mount, whether they are clamped or hinged, and it could be applied for micro-electro-mechanical switch design processes as an additional tool to control operational regimes.