RESUMO
The study involved 53 patients with arterial hypertension in chronic kidney disease (chronic glomerulonephritis (CGN)). Lipid peroxidation was studied based on the content of diene conjugates and malondialdehyde. Protein peroxidation was studied based on the content of 2,4-dinitphenyl-aldogidrazons. The patients in all clinical variants of the CGN revealed increased activity of lipid peroxidation and the protein peroxidation, which is most pronounced in patients with nephrotic variant of CGN: increased levels of serum malondialdehyde medians occurred in 3.92 times and diene conjugates in 1.52 times (p<0.01). Increased activity of the oxidation of lipids and proteins has a negative impact on the organization of cell membranes of the renal structures and leads to loss of membrane barrier function.
Assuntos
Hipertensão Renal/sangue , Falência Renal Crônica/sangue , Peroxidação de Lipídeos/genética , Lipídeos/sangue , Adolescente , Adulto , Feminino , Glomerulonefrite/sangue , Glomerulonefrite/complicações , Glomerulonefrite/patologia , Humanos , Hipertensão Renal/complicações , Hipertensão Renal/genética , Hipertensão Renal/patologia , Falência Renal Crônica/complicações , Falência Renal Crônica/patologia , Masculino , Malondialdeído/sangue , Pessoa de Meia-Idade , OxirreduçãoRESUMO
The paper was conducted sonographic study of extracranial atherosclerotic vascular changes in patients with diabetes mellitus, and lipid profile study of the dynamics under the influence of treatment with the inclusion of the drug "Reytoil". Structural changes of the vascular wall correlates with changes of lipid profile in patients with diabetes. Structural assessment of intima-media complex (IMC) can be used as a marker for early diagnosis of vascular remodeling in patients with diabetes, as well as the criterion of efficiency of a treatment. Detection of lipid exchange and evaluation of IMC in the early stages of diabetes mellitus will make it possible pathogenetic approach to providing comprehensive treatment of diabetes with dyslipidemia, including the drug "Reytoil".
Assuntos
Aterosclerose/prevenção & controle , Espessura Intima-Media Carotídea , Diabetes Mellitus Tipo 2/dietoterapia , Gorduras Insaturadas na Dieta/farmacologia , Dislipidemias/dietoterapia , Metabolismo dos Lipídeos/efeitos dos fármacos , Aterosclerose/sangue , Aterosclerose/etiologia , Artérias Carótidas/efeitos dos fármacos , Artérias Carótidas/patologia , HDL-Colesterol/sangue , LDL-Colesterol/sangue , VLDL-Colesterol/sangue , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/complicações , Dislipidemias/sangue , Dislipidemias/complicações , Humanos , Fatores de Risco , Triglicerídeos/sangue , Túnica Íntima/efeitos dos fármacos , Túnica Íntima/patologia , Túnica Média/efeitos dos fármacos , Túnica Média/patologiaRESUMO
Left ventricular diastolic dysfunction in patients with diabetes is formed in the absence of atherosclerotic changes as a consequence of diabetic cardiac autonomic neuropathy in the early stages of diabetes. Progression of autonomic cardiac neuropathy in cardio-vascular type is associated with the violation of energy supply of cells, protein synthesis, electrolyte exchange, the exchange of trace elements, oxidation reduction processes, oxygen-transport function of blood, so that metabolic therapy is carried out to optimize the processes of formation and energy costs. The drug cocarnit activates processes of aerobic oxidation of glucose, as well as providing regulatory influence on the oxidation of fatty acids. Applying of cocarnit in complex therapy in patients with diabetic cardiac autonomic neuropathy found improvement of left ventricular diastolic function, and positive dynamics in the efferent activity balance of the sympathetic and parasympathetic control of heart rate variability, which provides the regression of clinical symptoms.