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1.
Plant Signal Behav ; 13(6): e1477907, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29944442

RESUMO

In Arabidopsis thaliana, the bHLH transcription factor, GLABRA3 (AtGL3), is an important regulator of epidermal cell differentiation and positively controls anthocyanin accumulation. In contrast, we previously showed that Solanum lycopersicum GLABRA3 (SlGL3), the AtGL3 homolog, suppressed anthocyanin accumulation in Arabidopsis. To clarify this functional discrepancy in anthocyanin accumulation, we analyzed the SlGL3 expression pattern in anthocyanin-induced tomato. The SlGL3 expression was significantly reduced in tomato seedlings rich in anthocyanin as a result of inorganic phosphate (Pi) starvation. This was consistent with the previous result obtained in Arabidopsis, wherein the overexpression of SlGL3 was shown to inhibit anthocyanin accumulation. Our study suggests that the function of SlGL3 is different from that of AtGL3, and it might inhibit anthocyanin accumulation in tomato.


Assuntos
Antocianinas/metabolismo , Solanum lycopersicum/metabolismo , Arabidopsis/metabolismo , Proteínas de Arabidopsis/metabolismo , Regulação da Expressão Gênica de Plantas , Fosfatos/deficiência , Fosfatos/metabolismo , Plantas Geneticamente Modificadas/genética , Plantas Geneticamente Modificadas/metabolismo , Fatores de Transcrição/metabolismo
2.
Data Brief ; 18: 1773-1776, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29904678

RESUMO

Intercellular movement of transcription factor proteins is essential for plant development. The R3 type MYB transcription factor protein, CAPRICE (CPC), moves from non-hair cells to root-hair cells where it promotes root hair formation in Arabidopsis root epidermis. In contrast, the CPC homolog of ENHANCER OF TRY AND CPC1 (ETC1) cannot move in root epidermal cells. In this work, we present protein localization data of CPC-ETC1 chimeric proteins. Localization of CPC-ETC1-GFP fusion proteins of chimera1 and chimera2 transgenic plants was observed using confocal laser scanning microscope. Insertion of ETC1-specific amino acids into CPC somewhat prevents normal protein localization of CPC in root epidermal cells. Cell-to-cell movement of chimera1 and chimera2 proteins from non-hair cells to root-hair cells was interfered. Nuclear localization was also inhibited, especially in chimera1.

4.
Nat Commun ; 9(1): 1594, 2018 04 23.
Artigo em Inglês | MEDLINE | ID: mdl-29686394

RESUMO

The nuclear shell structure, which originates in the nearly independent motion of nucleons in an average potential, provides an important guide for our understanding of nuclear structure and the underlying nuclear forces. Its most remarkable fingerprint is the existence of the so-called magic numbers of protons and neutrons associated with extra stability. Although the introduction of a phenomenological spin-orbit (SO) coupling force in 1949 helped in explaining the magic numbers, its origins are still open questions. Here, we present experimental evidence for the smallest SO-originated magic number (subshell closure) at the proton number six in 13-20C obtained from systematic analysis of point-proton distribution radii, electromagnetic transition rates and atomic masses of light nuclei. Performing ab initio calculations on 14,15C, we show that the observed proton distribution radii and subshell closure can be explained by the state-of-the-art nuclear theory with chiral nucleon-nucleon and three-nucleon forces, which are rooted in the quantum chromodynamics.

5.
Skin Res Technol ; 23(4): 519-524, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28295641

RESUMO

BACKGROUND/PURPOSE: Presently, skin-cleaning agents that claim to be removed by water or wiping alone are commercially available and have been used for the purpose of bed baths. However, there is a lack of knowledge on how water washing and wiping differently affect skin physiological functions or ceramide content. The aim of this study was to compare the effects of water washing and wiping on skin physiological functions and ceramide content. METHODS: Three kinds of the cleaning agents with different removal techniques (ie, water washing and wiping) were used in this study. Skin physiological functions (ie, transepidermal water loss, skin hydration, and skin pH) and skin ceramide content were measured before and after seven consecutive days of the application of each cleaning agent. RESULTS: No significant differences in skin physiological functions or ceramide content were observed between water washing and wiping. CONCLUSION: Cleaning agents that claim to be removed by water washing or wiping do not affect skin physiological functions or ceramide content by either removal method.


Assuntos
Detergentes/farmacologia , Higiene , Fenômenos Fisiológicos da Pele/efeitos dos fármacos , Ceramidas/análise , Fármacos Dermatológicos/farmacologia , Voluntários Saudáveis , Humanos , Concentração de Íons de Hidrogênio/efeitos dos fármacos , Estado de Hidratação do Organismo/efeitos dos fármacos , Pele/química , Higiene da Pele , Água , Perda Insensível de Água/efeitos dos fármacos , Adulto Jovem
6.
CPT Pharmacometrics Syst Pharmacol ; 3: e115, 2014 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-24850445

RESUMO

Model-based meta-analysis of dose response is a sophisticated method to guide dose and regimen selection. In this report, the effects of paclitaxel dose and regimen (weekly or every 3 weeks) on the efficacy and safety in cancer patients were quantified by model-based meta-analysis of 29 monotherapy trials. Logistic regression models were developed to assess the relationship between dose and objective response rate or neutropenia rate. Survival models were developed to assess the relationship between dose and overall survival or progression-free survival. Paclitaxel efficacy (e.g., objective response rate, median overall survival, and progression-free survival) is correlated with average dose per week (mg/m(2)/week), whereas safety (e.g., neutropenia rate) is correlated with dose per administration (mg/m(2)). Weekly paclitaxel regimen at 65-80 mg/m(2) is supported to have comparable to better efficacy and lower neutropenia incidence than an every-3-week regimen at 175 mg/m(2).

7.
Spectrochim Acta A Mol Biomol Spectrosc ; 128: 176-82, 2014 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-24667422

RESUMO

Pulsed ArF excimer laser (193 nm)-CW infrared (IR) tunable diode laser Herriott type absorption spectroscopic technique has been made for the detection of product hydrochloric acid HCl. Absorption spectroscopic technique is used in the reaction chlorine atoms with methyl iodide (Cl+CH3I) to the study of kinetics on reaction Cl+CH3I and the yield of (HCl). The reaction of Cl+CH3I has been studied with the support of the reaction Cl+C4H10 (100% HCl) at temperature 298 K. In the reaction Cl+CH3I, the total pressure of He between 20 and 125 Torr at the constant concentration of [CH3I] 7.0×10(14) molecule cm(-3). In the present work, we estimated adduct formation is very important in the reaction Cl+CH3I and reversible processes as well and CH3I molecule photo-dissociated in the methyl [CH3] radical. The secondary chemistry has been studied as CH3+CH3ICl = product, and CH3I+CH3ICl = product2. The system has been modeled theoretically for secondary chemistry in the present work. The calculated and experimentally HCl yield nearly 65% at the concentration 1.00×10(14) molecule cm(-3) of [CH3I] and 24% at the concentration 4.0×10(15) molecule cm(-3) of [CH3I], at constant concentration 4.85×10(12) molecule cm(-3) of [CH3], and at 7.3×10(12) molecule cm(-3) of [Cl]. The pressure dependent also studied product of HCl at the constant [CH3], [Cl] and [CH3I]. The experimental results are also very good matching with the modelling work at the reaction CH3+CH3ICl = product (k = (2.75±0.35)×10(-10) s(-1)) and CH3I+CH3ICl = product2 (k = 1.90±0.15)×10(-12) s(-1). The rate coefficients of the reaction CH3+CH3ICl and CH3I+CH3ICl has been made in the present work. The experimental results has been studied by two method (1) phase locked and (2) burst mode.


Assuntos
Cloro/química , Hidrocarbonetos Iodados/química , Ácido Clorídrico/química , Modelos Químicos , Cinética , Espectrofotometria Atômica
8.
Clin Exp Obstet Gynecol ; 40(4): 604-6, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24597269

RESUMO

Early detection of ovarian pregnancy (OP) is essential for successful laparoscopic conservative surgery. However, early preoperative ultrasonography-based diagnosis is often difficult when fetal cardiac activity or the yolk sac is absent. The authors report a case of OP diagnosed at eight weeks gestational age in a natural pregnancy. The patient presented with amenorrhea and transient vaginal bleeding, and slight tenderness in the right ovary was noted during vaginal ultrasonography. Furthermore, ultrasonography showed a gestational sac (GS) without fetal cardiac activity or yolk sac, consistent with OP, and an adjacent compressible lutein cyst. The uterus, fallopian tubes, and left ovary were normal, and no cul-de-sac blood or ascites were found. Laparoscopy showed a two-cm mass partially covering the right ovary, which contained an unruptured GS. Subsequently, the mass was removed, and OP was histologically confirmed.


Assuntos
Laparoscopia , Gravidez Ectópica/cirurgia , Adulto , Amenorreia , Feminino , Idade Gestacional , Humanos , Gravidez , Gravidez Ectópica/diagnóstico por imagem , Gravidez Ectópica/patologia , Ultrassonografia , Hemorragia Uterina
9.
Obes Rev ; 14(2): 110-28, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23174017

RESUMO

Taxes and subsidies are increasingly being considered as potential policy instruments to incentivize consumers to improve their food and beverage consumption patterns and related health outcomes. This study provided a systematic review of recent U.S. studies on the price elasticity of demand for sugar-sweetened beverages (SSBs), fast food, and fruits and vegetables, as well as the direct associations of prices/taxes with body weight outcomes. Based on the recent literature, the price elasticity of demand for SSBs, fast food, fruits and vegetables was estimated to be -1.21, -0.52, -0.49 and -0.48, respectively. The studies that linked soda taxes to weight outcomes showed minimal impacts on weight; however, they were based on existing state-level sales taxes that were relatively low. Higher fast-food prices were associated with lower weight outcomes particularly among adolescents, suggesting that raising prices would potentially impact weight outcomes. Lower fruit and vegetable prices were generally found to be associated with lower body weight outcomes among both low-income children and adults, suggesting that subsidies that would reduce the cost of fruits and vegetables for lower-socioeconomic populations may be effective in reducing obesity. Pricing instruments should continue to be considered and evaluated as potential policy instruments to address public health risks.


Assuntos
Peso Corporal , Dieta/economia , Alimentos/economia , Programas Governamentais , Saúde Pública , Bebidas/economia , Bebidas/provisão & distribuição , Custos e Análise de Custo , Dieta/normas , Dieta/estatística & dados numéricos , Fast Foods/economia , Fast Foods/provisão & distribuição , Alimentos/normas , Alimentos/estatística & dados numéricos , Abastecimento de Alimentos/economia , Abastecimento de Alimentos/normas , Abastecimento de Alimentos/estatística & dados numéricos , Frutas/economia , Frutas/provisão & distribuição , Programas Governamentais/economia , Programas Governamentais/legislação & jurisprudência , Promoção da Saúde/economia , Humanos , Obesidade/economia , Obesidade/epidemiologia , Obesidade/prevenção & controle , Marketing Social , Fatores Socioeconômicos , Impostos/economia , Estados Unidos/epidemiologia , Verduras/economia , Verduras/provisão & distribuição
10.
Phys Rev Lett ; 108(17): 172701, 2012 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-22680857

RESUMO

Clustering in low density nuclear matter has been investigated using the NIMROD multidetector at Texas A&M University. Thermal coalescence modes were employed to extract densities, ρ, and temperatures, T, for evolving systems formed in collisions of 47A MeV (40)Ar+(112)Sn, (124)Sn and (64)Zn+(112)Sn, (124)Sn. The yields of d, t, (3)He, and (4)He have been determined at ρ=0.002 to 0.03 nucleons/fm(3) and T=5 to 11 MeV. The experimentally derived equilibrium constants for α particle production are compared with those predicted by a number of astrophysical equations of state. The data provide important new constraints on the model calculations.

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