A Technique for Arthroscopic Fixation of Tibial Eminence Avulsion Fractures: A Physeal-Sparing Construct With All-Suture Anchor Bridge Fixation.

Arthroscopic or open surgical treatment is indicated for displaced tibial spine fractures to obtain anatomic reduction and restore the functionality of the anterior cruciate ligament. Numerous open and arthroscopic techniques for the treatment of tibial spine fractures have been described. The purpose of this technical note is to describe a minimally invasive arthroscopic physeal- and ligament-sparing surgical technique using knotless all-suture anchors to provide stable bridge fixation over displaced tibial spine fractures.

Management of Postoperative Infection After Fixation of a Delbet Type III Pediatric Femoral Neck Fracture: A Case Report.

CASE: A pediatric male patient sustained a postoperative infection of the femoral neck after open anatomic reduction and internal fixation (ORIF) of a Delbet type III femoral neck fracture. Treatment included surgical intervention with antibiotic Steinmann pins incorporated into an external fixator to provide stability to the femoral neck. At the 27-month follow-up, films showed complete healing with a 1.67-cm leg length discrepancy, treated with a 1-cm shoe lift. CONCLUSION: There is insufficient literature for the treatment of postoperative infection after ORIF in a pediatric patient. We present a successful treatment method for treating an infection while sustaining the stability of the femoral neck.

Revision pediatric anterior cruciate ligament reconstruction after failure of iliotibial band technique treated with all-epiphyseal technique in a prepubescent with Ehlers-Danlos syndrome: a case report.

The increasing number of pediatric anterior cruciate ligament (ACL) injuries and the failure of nonoperative management of these patients has elicited a concordant response in the surgical community to devise reconstruction techniques that stabilize the knee joint without causing iatrogenic growth disturbances. Likewise, the rise in pediatric ACL reconstructions forecasts a consequent rise in revision ACL reconstructions in patients with open physes. In this case report, we describe a prepubescent with Ehlers-Danlos syndrome and congenital ACL deficiency, who underwent physeal-sparing iliotibial band ACL reconstruction and revision to an all-epiphyseal ACL reconstruction with allograft. We also underscore the lack of evidence addressing graft choice and outcomes for ACL reconstructions in patients with connective tissue disorders.

Subscapularis avulsion of the lesser tuberosity in adolescents.

BACKGROUND: Lesser tuberosity avulsion fractures in adolescents occur infrequently. Perhaps because of their rarity, many cases are missed on initial physical exam, imaging studies, and even diagnostic arthroscopy, leading to delay in diagnosis. Without operative intervention, these injuries may cause significant morbidity, whereas operative fixation has predictably good results. We review 6 cases and compare them to a review of the previous published cases. METHODS: All cases of isolated lesser tuberosity avulsions in skeletally immature patients treated by the senior author (MTB) at a pediatric referral center were included. The mean follow-up was over 4 years (range, 2 to 7 y). Operative treatment consisted of a diagnostic arthroscopy to evaluate for concomitant pathology, followed by an open reattachment of the tuberosity through an incision in line with the anterior axillary fold. A lasso technique using suture anchors and sutures to loop over and hold down the fragment is our preferred method as it decreases the risk of fracture seen with fixation using screws or sutures through drill holes in the tuberosity. RESULTS: Even with a frequent delay in diagnosis, all patients had a predictably good outcome with an average American Shoulder and Elbow Surgeons score of 97 (range, 88 to 100) and a Western Ontario Shoulder Instability Index of 94 (range, 84 to 100). The patient history, symptoms, and physical exam findings were consistent across the published cases. The prototypical patient is a male, age 13, who sustains an abduction and extension injury during sports. Anterior shoulder pain, positive belly press, and lift-off signs are frequent findings. CONCLUSIONS: A high index of suspicion is needed to recognize this uncommon injury. History, physical exam for subscapularis function, and magnetic resonance imaging should be diagnostic. Operative treatment with a suture anchor lasso technique leads to predictably good results. LEVEL OF EVIDENCE: Level IV therapeutic study.

Infection after spinal fusion for pediatric spinal deformity: thirty years of experience at a single institution.

STUDY DESIGN: A retrospective, consecutive case study of 1571 pediatric patients who underwent spinal deformity surgery and had minimum 2-year follow-up. OBJECTIVE: To identify (1) the rate of infection after pediatric spinal deformity surgery; (2) the number of surgeries required to treat a postoperative infection after a pediatric spinal deformity surgery; (3) the percentage of patients with a postoperative infection after pediatric spinal deformity surgery who require implant removal to quantify the effect of removal on the deformity; and (4) the microbiology of postoperative infections after pediatric spinal deformity surgery. SUMMARY OF BACKGROUND DATA: Several previous reports have discussed the rates of infection after spinal surgery for pediatric spinal deformity. No previous reports have quantified the rate and magnitude of deformity progression after infection in pediatric spinal deformity surgery. METHODS: A retrospective review was performed of the medical records and radiographs of all children undergoing surgery for spinal deformity at the Shriners Hospital for Children in Chicago from January 1, 1975, to June 1, 2005. RESULTS: The rate of infection varied based on underlying diagnosis: idiopathic scoliosis 0.5%, myelomeningocele 19.2%, myopathies 4.3%, and cerebral palsy 11.2%. On average, 2 surgeries were required to eradicate the infection. Approximately half of the patients required removal of the instrumentation to treat their infection. Forty-four percent of patients who developed an infection had significant progression of their deformity, with an average increase in deformity magnitude of 27 degrees. Implant removal predisposed patients to progression of deformity. The 3 most common organisms in order were Staphylococcus aureus, S. epidermidis, and Pseudomonas aeruginosa. CONCLUSION: Infection after spinal deformity in idiopathic scoliosis is rare but is relatively common in neuromuscular conditions. Eradication of infection can be expected, but implant removal is often required. Should implants be totally removed, significant progression of the deformity is possible.

Intravascular ultrasound molecular imaging of atheroma components in vivo.

OBJECTIVES: Our purpose was to quantitate and confirm specific echogenic immunoliposome (ELIP) atheroma component enhancement in vivo. BACKGROUND: Targeted ELIPs for ultrasonic detection and staging of active molecular components of endothelium and atheroma have been developed. METHODS: In Yucatan miniswine, the endothelium was injured from one femoral and one carotid artery, and animals were fed a high-cholesterol diet for two months to create various stages of atheroma. Arteries were imaged with intravascular ultrasound (IVUS) 5 and 10 min after ELIP injection (5-mg dose). Anti-intercellular adhesion molecule-1 (ICAM-1), anti-vascular cell adhesion molecule-1 (VCAM-1), anti-fibrin, anti-fibrinogen, and anti-tissue factor (TF) conjugated ELIPs were used, and immunohistochemistry (IHC) confirmed the presence or absence of molecular expression. Two blinded observers determined if each segment was enhanced by ELIP. Three-dimensional image reconstruction and videodensitometric analysis determined the mean gray-scale (MGS) change of the luminal border. RESULTS: To determine endothelial injury component enhancement, anti-fibrinogen ELIP enhanced exposed fibrin in all arteries (MGS increased 22 +/- 5%; 6 arteries; 2 animals). To determine enhancement of molecular components in atherosclerotic arteries, observers detected enhancement 5 min after anti-VCAM, anti-ICAM, anti-TF, anti-fibrin, and anti-fibrinogen conjugated ELIPs. Furthermore, ELIP enhanced atheroma MGS by 39 +/- 18% (n = 8). The IHC staining confirmed the expression of respective molecular targets in all enhanced segments. CONCLUSIONS: It was shown that ELIPs specifically enhance endothelial injury/atheroma components. This allows better characterization of the type and extent of active atheroma components and may allow more directed therapy.

Left ventricular thrombus enhancement after intravenous injection of echogenic immunoliposomes: studies in a new experimental model.

BACKGROUND: Targeted echogenic immunoliposomes (ELIPs) for ultrasound enhancement of atheroma components have been developed. To date, ELIP delivery has been intra-arterial. To determine whether ELIPs can be given intravenously with enhancement of systemic structures, a left ventricular thrombus (LVT) model was developed. METHODS AND RESULTS: In 6 animals plus 1 dose-ranging animal, the apical coronary arteries were ligated, and an LVT was produced by injecting Hemaseel fibrin adhesive through the apical myocardium. The thrombus was imaged epicardially and transthoracically at 0, 1, 5, and 10 minutes after anti-fibrinogen ELIP injections. The dose of ELIPs was varied. PBS and unconjugated ELIPs were controls. The apical thrombi were easily reproduced and clearly visible with epicardial and transthoracic ultrasound. Enhancement occurred with 2 mg anti-fibrinogen ELIPs and increased with dose. With 8 mg ELIPs, enhancement was different from control within 10 minutes (P<0.05). Rhodamine-labeled anti-fibrinogen ELIPs were seen with fluorescence microscopy of the LVT. Blinded viewing detected enhancement by 10 minutes in all animals after anti-fibrinogen ELIPs. CONCLUSIONS: We describe an easily reproducible LVT model. Anti-fibrinogen ELIPs delivered intravenously, as a single-step process, rapidly enhance the ultrasound image of a systemic target. This allows for future development of ELIPs as a targeted ultrasound contrast agent.