Eco-Stoichiometric Characteristics of Rhizosphere and Bulk Soils of Smilax china L. along Vertical Zone Spectrum of Fanjing Mountain.

To explore the correlations between nutrients and stoichiometric characteristics in the rhizosphere and bulk soils of understory Smilax china L. in forest ecosystems at different altitudes and to clarify the rhizosphere effect of understory vegetation in forest ecosystems and its response strategy to altitude, providing a theoretical basis for better forest ecological environment protection and high-quality development in Fanjing Mountain. Understory Smilax china L. at four different altitudes were selected, with the differences and influencing factors of carbon (C), nitrogen (N), phosphorus (P) and potassium (K) mass fractions and stoichiometric ratios in their rhizosphere and bulk soils analyzed. The average mass fractions of total C, total N and alkali-hydrolyzed N in the rhizosphere and bulk soils of Smilax china L. at different altitudes were 224.43 and 181.55 g·kg-1; 9.56 and 6.81 g·kg-1; and 648.19 and 600.70 g·kg-1, respectively. The rhizosphere effect of Smilax china L. was significant at altitudes of 500 m and 1000 m but became not so prominent with the rise of altitude. The C:N ratio in the rhizosphere and bulk soils ranged from 19.51 to 39.75 and the C:P ratio ranged from 225.29 to 543.05. C accumulation is greater than N accumulation in the rhizosphere and bulk soils of Smilax china L., and both present P limitation. Based on the comprehensive analysis of the mass fractions and eco-stoichiometric ratios of soil nutrients, the P limitation in Fanjing Mountain forest ecosystem is commonly seen and should be addressed.

The Short-Term Effects of Ambient Air Pollutants are Associated With Daily Mortality in Northeast China From 2014 to 2018: A Time Series Analysis.

OBJECTIVE: We aimed to examine the associations between ambient air pollutants and daily mortality in Northeast China from 2014 to 2018. METHODS: A two-stage approach was used to estimate particulate matter with an aerodynamic diameter of 10 µm (PM10), nitrogen dioxide (NO2), and sulfur dioxide (SO2) exposure and daily mortality. RESULTS: An increase of 10 µg/m3 of PM10 exposure and NO2 at lag of 0 to16 days was associated with the cumulative relative risk of 1.011 (95% confidence interval [CI]: 1.004, 1.019) and 1.026 (95% CI: 1.004, 1.049), respectively, in non-accident mortality. Meanwhile, significant association was observed in people aged under 60 years between SO2 exposure and respiratory mortality at lag of 0 to 9 days. CONCLUSIONS: Our findings strengthen the evidence of PM10 and NO2 exposures were independent risk for daily mortality.

Evaluation of immunotherapy and targeted therapy treatment on renal cell carcinoma: A Bayesian network analysis.

Clinical trials have previously assessed various therapies for renal cell carcinoma (RCC); however, there is currently a lack of direct comparisons between these therapies. The present study identified published studies on RCC through Web of Science, PubMed, EMBASE, Cochrane Library of Controlled Trials and Clinical trials.gov that were written in the English language and published by February 2019. The data were selected and extracted independently by two reviewers. Standard pair-wise meta-analyses were performed using Stata. Network meta-analyses were subsequently performed using WinBUGS (version 1.4.3). The primary outcome of the present study was progression-free survival (PFS). Secondary outcomes included overall survival (OS), objective response rate (ORR) and adverse events of various targeted therapies. The results were presented as cumulative odds ratio, hazard ratio, corresponding 95% confidence interval and the surface under the cumulative ranking curve, which was used to rank the probabilities and outcome of each treatment in RCC. A total of 31 eligible publications for 18 randomized controlled trials consisting of 11,498 participants were included in the present study. The network meta-analyses revealed that a combination of lenvantinib and everolimus ranked first out of 16 treatments in terms of PFS, OS and ORR (probability of 54.0, 53.4 and 61.0%, respectively).