Predictors of Quality of Life Following Cognitive Processing Therapy Among Women and Men With Post-Traumatic Stress Disorder.

INTRODUCTION: The effect of evidence-based post-traumatic stress disorder (PTSD) treatments on quality of life (QOL) is not well understood. In light of mixed findings on QOL after PTSD interventions, little is known about why some individuals experience functional and QOL improvements while others do not. This study examined treatment-related changes in depression, anger, and PTSD following cognitive processing therapy (CPT) as potential predictors of QOL change. MATERIALS AND METHODS: Data from two randomized controlled trials, one examining CPT among female civilians and veterans (women's study NCT02362477; n = 126) and the other on CPT delivered to male veterans (men's study NCT00879255; n = 125), were used to test study aims. Linear mixed modeling examined changes in depression, anger, and PTSD as predictors of post-treatment QOL while controlling for baseline QOL. The VA Pacific Island Health Care System's Institutional Review Board approved all study procedures. RESULTS: Among women, reductions in depression from pre- to post-treatment had the strongest predictive value of post-treatment QOL (B = -1.15, 95% confidence interval (-1.71, -0.60), t = -4.07, P < .001). For men, reductions in trait anger from pre- to post-treatment predicted post-treatment QOL (B = -0.55, 95% confidence interval (-0.90, -0.19), t = -3.00, P = .003). CONCLUSIONS: Improvements in QOL may be predicted by different symptoms for men and women following evidence-based PTSD treatment. Our findings suggest that change in depression symptoms is an important predictor of post-treatment QOL among women, while anger symptoms are more influential for men. QOL and functioning is underresearched within the context of PTSD treatment, and this study suggests that these domains should be examined within the context of gender.

PTSD treatment response and quality of life in women with childhood trauma histories.

OBJECTIVE: Childhood trauma is associated with greater psychological problems and poorer quality of life (QOL). This study evaluates the effect of multiple types of childhood trauma on posttraumatic stress disorder (PTSD) and QOL following cognitive processing therapy (CPT). Understanding how the breadth of traumatic experiences in childhood can influence psychosocial treatment outcomes may help to identify the unique needs of this population. METHOD: This secondary data analysis of a randomized controlled trial delivering CPT to civilian (n = 105) and veteran women (n = 21) with PTSD used linear regressions to examine relationships between the number of unique types of childhood trauma, PTSD, and QOL before and after treatment. Models controlled for demographic information, adult trauma, and pretreatment PTSD, depression, and QOL scores. RESULTS: More types of childhood trauma predicted pretreatment PTSD symptoms (B = 1.98, p = .02) but not QOL (B = -.018, p = .18). Significant reductions in Clinician-Administered PTSD Scale for DSM-IV-TR score, t(302) = 10.32, p < .001, and QOL, t(309) = -4.06, p < .001, were reported after treatment; number of traumatic event types was not predictive of QOL change (B = .01, p = .957). Women with more types of trauma reported significantly less PTSD symptom reduction when compared with those with one type (B = 3.12, p = .042). CONCLUSION: Women who experienced a broader range of childhood trauma may experience diminished PTSD symptom reduction following CPT in comparison with women with less exposure. On average, all women, regardless of trauma history, reported small improvements in QOL. Clinical considerations are discussed. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Quality of life following treatment for PTSD: Comparison of videoconferencing and in-person modalities.

INTRODUCTION: Quality of life (QOL) is significantly impaired among individuals with post-traumatic stress disorder (PTSD); however, few treatment outcome studies examine QOL following treatment. Furthermore, the use of videoconferencing to deliver evidence-based treatments for PTSD is increasing dramatically. Although videoconferencing has demonstrated non-inferiority to in-person treatment modalities for improving PTSD symptom severity, no studies to date have directly compared QOL outcomes of an evidence-based intervention delivered via videoconferencing to one delivered in-person. METHODS: This study presents a secondary data analysis of two randomized controlled trials comparing cognitive processing therapy (CPT) delivered via videoconferencing or a traditional in-person modality. The Men's study delivered group CPT to 125 male veterans with PTSD, whereas the Women's study delivered individuals CPT to 126 female civilians and veterans. Multigroup latent growth curve models were used to model changes in QOL Inventory (QOLI) scores over time. RESULTS: There was no effect of treatment modality on changes in QOLI scores over time (modality effect on slope estimate = 0.004 (-0.60, 0.61) and on quadratic estimate = 0.001 (-0.18, 0.20); all ps > 0.33). Model fit was the same for both genders (Δ χ2 (2) = 2.28, p = 0.32) and for the gender × treatment modality interaction (Δ χ2 (2) = 2.87, p = 0.24). QOLI scores improved at post-treatment and three-month follow-up assessments, but declined at the six-month follow-up assessment. DISCUSSION: This secondary analysis extends the findings of the parent studies by establishing the efficacy of the videoconferencing platform in improving QOL. Clinical implications of findings are discussed.