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1.
Bioethics ; 2024 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-38757538

RESUMO

This article considers aspects of a development aid that provides medical support to strengthen pediatric orthopedics in Rwanda. We present part of the Afriquia foundation work, a nonprofit foundation from Poland involved in supporting the medical sector in Rwanda as a sign of global solidarity and the human right to health. The main foundation's activity is the treatment of orthopedic problems among Rwandan citizens. We present a case study of two children under the care of the Afiquia foundation. 11-year-old Seraphine treated due to the consequences of right tibia osteomyelitis and 11-year-old Lavi suffering from osteogenesis imperfecta. Both children were treated surgically in Poland due to Rwanda's lack of treatment possibilities. After the applied treatment, Seraphine walks correctly without crutches and can attend school and thrive among her peers. Lavi has not sustained any fragility fracture since the surgery in Poland. He is healthy and constantly ongoing his rehabilitation including gait training. The described cases initiated development aid in Rwanda, supplying hospitals with orthopedic implants and training medical staff. The growing number of humanitarian crises across the globe and the people affected requires increasing organizations involved in providing relief. The emphasis should be on global education, aiming to make the recipients reflect and prepare them to face humanitarian crises.

2.
BMC Musculoskelet Disord ; 25(1): 333, 2024 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-38671411

RESUMO

PURPOSE: The aim of this study was to investigate the efficacy of TXA supplemented with local infiltration analgesia (LIA) for reducing blood loss in patients undergoing total knee replacement. MATERIALS: A retrospective study of 530 individuals with a mean age of 71.44 years was performed after posterior stabilized total knee arthroplasty. Patients were divided into three groups according to the method of bleeding control: I - patients without an additional bleeding protocol (control group); II - patients receiving IV TXA (TXA group); and III - patients receiving the exact TXA protocol plus intraoperative local infiltration analgesia (TXA + LIA group). Blood loss was measured according to the maximal decrease in Hb compared to the preoperative Hb level. RESULTS: The mean hospitalization duration was 7.02 (SD 1.34) days in the control group, 6.08 (SD 1.06) days in the TXA group, and 5.56 (SD 0.79) in the TXA + LIA group. The most significant decrease in haemoglobin was found in the control group, which was an average of 30.08%. The average decrease in haemoglobin was 25.17% (p < 0.001) in the TXA group and 23.67% (p < 0.001) in the TXA + LIA group. A decrease in the rate of allogeneic blood transfusions was observed: 24.4% in the control group, 9.9% in the TXA group, and 8% in the TXA + LIA group (p < 0.01). CONCLUSIONS: Compared to the separate administration of tranexamic acid, the combination of perioperative administration with local infiltration analgesia significantly reduced blood loss in patients after total knee replacement.


Assuntos
Antifibrinolíticos , Artroplastia do Joelho , Perda Sanguínea Cirúrgica , Ácido Tranexâmico , Humanos , Ácido Tranexâmico/administração & dosagem , Artroplastia do Joelho/efeitos adversos , Idoso , Feminino , Masculino , Estudos Retrospectivos , Perda Sanguínea Cirúrgica/prevenção & controle , Pessoa de Meia-Idade , Antifibrinolíticos/administração & dosagem , Idoso de 80 Anos ou mais , Resultado do Tratamento , Anestésicos Locais/administração & dosagem , Analgesia/métodos , Hemoglobinas/análise , Hemoglobinas/metabolismo , Anestesia Local/métodos
3.
Ortop Traumatol Rehabil ; 25(4): 219-227, 2023 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-37947146

RESUMO

The incidence of anterior cruciate ligament (ACL) injuries in children and adolescents has been growing recently. This problem is a challenge for the treating orthopedic surgeon, especially when the patient is in the prepubertal period with a high growth potential. Since reconstructive procedures require interventions close to active growth plates, they are associated with the risk of postoperative limb length discrepancies and limb deformities. Postponing ACL reconstruction until the end of growth is not a solution, as persistent knee instability increases the risk of secondary intra-articular damage. The key to success is not only knowledge of the anatomy and biomechanics of the pediatric knee but also the ability to predict the remaining growth potential and familiarity with a wide range of reconstructive surgical procedures available for patients at different ages.


Assuntos
Lesões do Ligamento Cruzado Anterior , Reconstrução do Ligamento Cruzado Anterior , Traumatismos do Joelho , Adolescente , Humanos , Criança , Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior/cirurgia , Articulação do Joelho/cirurgia , Traumatismos do Joelho/cirurgia , Traumatismos do Joelho/epidemiologia , Reconstrução do Ligamento Cruzado Anterior/métodos
4.
Sci Rep ; 13(1): 17304, 2023 10 12.
Artigo em Inglês | MEDLINE | ID: mdl-37828062

RESUMO

This study aimed to investigate the efficacy of tranexamic acid supplemented with local infiltration analgesia in reducing blood loss in patients undergoing unicompartmental knee arthroplasty (UKA). This retrospective study was conducted on 176 individuals with a mean age of 64.27 (standard deviation [SD], 7.16) years undergoing unicompartmental cemented knee arthroplasty. The patients were divided into three groups according to patient blood management: I, patients without additional bleeding protocol (control group); II, patients intravenously administered tranexamic acid (TXA) (TXA group); and III, patients with exact TXA protocol combined with intraoperative local infiltration analgesia (LIA) (TXA + LIA group). Blood loss was measured as a substitute for blood loss by the maximal haemoglobin (Hb) drop compared with the preoperative Hb level. The mean Hb drops for the control, TXA, and TXA + LIA groups were 2.24 (16.0%), 2.14 (15.4%), and 1.81 (12.6%) g/dl, respectively. The mean hospitalisation days for patients in the control, TXA, and TXA + LIA groups were 5.91 (SD 1.24), 5.16 (SD 0.95), and 4.51 (SD 0.71) days, respectively. The combination of TXA with LIA reduces perioperative blood loss for patients after UKA.


Assuntos
Analgesia , Antifibrinolíticos , Artroplastia do Joelho , Ácido Tranexâmico , Humanos , Pessoa de Meia-Idade , Artroplastia do Joelho/efeitos adversos , Artroplastia do Joelho/métodos , Antifibrinolíticos/uso terapêutico , Estudos Retrospectivos , Perda Sanguínea Cirúrgica/prevenção & controle
5.
Children (Basel) ; 10(2)2023 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-36832507

RESUMO

Extracorporeal membrane oxygenation (ECMO) is an increasingly popular method for the treatment of patients with life-threatening conditions. The case we have described is characterized by the effectiveness of therapy despite resuscitation lasting more than one hour. A 3.5-year-old girl with a negative medical history was admitted to the Department of Cardiology due to ectopic atrial tachycardia. It was decided to perform electrical cardioversion under intravenous anaesthesia. During the induction of anaesthesia, cardiac arrest with pulseless electrical activity (PEA) occurred. Despite resuscitation, a permanent hemodynamically effective heart rhythm was not achieved. Due to prolonged resuscitation (over one hour) and persistent PEA, it was decided to use veno-arterial extracorporeal membrane oxygenation. After three days of intensive ECMO therapy, hemodynamic stabilization was achieved. The time of implementing ECMO therapy and assessment of the initial clinical status of the patient should be emphasized.

6.
Front Pediatr ; 11: 1325459, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38250596

RESUMO

This study reported a case of radius flexible intramedullary nailing complicated by temporary paralysis of the posterior interosseous nerve due to compression of the ESIN on the nerve in an 8-year-old boy. The nerve damage resulted from an essential misconception at the surgery. Despite bad decisions made during qualifications and the procedure undertaken, restoring the nerve function, and gaining satisfactory functional fracture recovery was possible. Although it is generally acknowledged to perform retrograde flexible intramedullary nailing from the level of the distal radial metaphysis, the presentation of our case aims to emphasize the real risk of damage to the motor branch of the radial nerve when approaching the proximal metaphysis.

7.
Children (Basel) ; 9(12)2022 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-36553339

RESUMO

(1) Background: Anterior cruciate ligament avulsion fractures are characteristic for skeletally immature patients, and appropriate treatment is currently debated in the literature. The study aimed to evaluate the clinical and functional outcomes in patients with tibial eminence fractures treated with bioabsorbable nails in one orthopedic clinic. (2) Methods: After retrospective evaluation, we found 17 patients with tibial eminence fractures treated in orthopedic departments between January 2013 and July 2022 using bioabsorbable fixation nails. The study group comprised 12 boys and five girls aged 5 to 15.2 (average 10.1). The mean follow-up was 28 months. We diagnosed five type II fractures, ten type III fractures, and two type IV fractures according to Meyers-McKeever classification. (3) Results: We obtained a high healing rate-17 patients with the complete union on the control radiographs. We diagnosed two cases of malunion, of which one required revision surgery. Only one patient showed a slight anterior knee laxity. The treatment effect at follow-up was assessed using the Lysholm Knee Score and IKDC Score. The median Lysholm Score was 96.64 (SD 4.54), and the median IKDC Score was 84.64 (SD 3.10), which were both excellent results. (4) Conclusions: Based on our results, surgery using bioabsorbable devices for type II, III, and IV tibial eminence fractures in young individuals is an effective alternative, allowing good outcomes and restoring proper knee stability. The crucial factor for a good effect is a stable fracture fixation. Arthroscopic surgery gives good outcomes with minimal invasion. It is important not to prolong the attempts of arthroscopic reduction and to perform the open reduction to shorten the procedure's time and avoid complications.

8.
Medicina (Kaunas) ; 58(11)2022 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-36363527

RESUMO

Background and Objectives:Due to the rarity of radial nerve palsy in humeral shaft fractures in the paediatric population and the lack of data in the literature, the purpose of our study was to report the treatment results of six children who sustained a radial nerve injury following a humeral shaft fracture. Materials and Methods: We treated six paediatric patients with radial nerve palsy caused by a humeral shaft fracture in our department from January 2011 to June 2022. The study group consisted of four boys and one girl aged 8.6 to 17.2 (average 13.6). The mean follow-up was 18.4 months. To present our results, we have used the STROBE protocol designed for retrospective observational studies. Results:We diagnosed two open and four closed humeral shaft fractures. Two simple transverse AO 12A3c; one simple oblique AO 12A2c; two simple spiral AO 12A1b/AO 12A1c and one intact wedge AO 12B2c were recognized. The humeral shaft was affected in the distal third five times and in the middle third one time. In our study group, we found two cases of neurotmesis; two entrapped nerves within the fracture; one stretched nerve over the bone fragments and one case of neuropraxia. We found restitution of the motor function in all cases. For all patients, extensor muscle strength was assessed on the grade M4 according to the BMRC scale (except for a patient with neuropraxia-M5). The differences in patients concerned the incomplete extension at the radiocarpal and metacarpophalangeal (MCP) joints. Conclusions: In our small case series, humeral shaft fractures complicated with radial nerve palsy are always challenging medical issues. In paediatric patients, we highly recommend an US examination where it is possible to be carried out to improve the system of decision making. Expectant observation with no nerve exploration is reasonable only in close fractures caused by low-energy trauma. Early surgical nerve exploration related with fracture stabilisation is highly recommended in fractures after high-energy trauma, especially in open fractures and where symptoms of nerve palsy appear at any stage of conservative treatment.


Assuntos
Fraturas do Úmero , Neuropatia Radial , Masculino , Feminino , Humanos , Criança , Neuropatia Radial/etiologia , Neuropatia Radial/diagnóstico , Neuropatia Radial/cirurgia , Estudos Retrospectivos , Fraturas do Úmero/complicações , Fraturas do Úmero/cirurgia , Nervo Radial/lesões , Nervo Radial/cirurgia , Úmero , Fixação Interna de Fraturas/efeitos adversos
9.
J Clin Med ; 11(18)2022 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-36143038

RESUMO

(1) Background: This is the first systematic review concerning the treatment of osteochondritis dissecans with the use of bioabsorbable implants. The study was done as a comprehensive review to identify important factors affecting the results of OCD treatment in children and adolescents; (2) Methods: We searched electronic bibliographic databases including PubMed, Cochrane Library, Scopus, and Web of Knowledge until May 2022. This systematic review was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and PICO (Patients, Interventions, Comparisons, Outcomes) guidelines; (3) Results: We identified 2662 original papers of which 11 were found to be eligible for further analysis. The study group included a total of 164 OCD lesions in 158 patients. In 94.86% of postoperative cases, there was complete healing or local improvement on follow-up CT or MRI scans. The great majority of patients achieved a good clinical effect. Out of 164 OCD lesions, 10 did not heal (6.09%); (4) Conclusions: Surgical treatment of stable and unstable OCD in children with the use of bioabsorbable implants facilitates a high rate of healing and a good clinical outcome; treatment of juvenile OCD is associated with a better outcome compared to adult OCD; the use of bioabsorbable implants for the treatment of humeral capitellum OCD is associated with a more frequent incidence of synovitis (18.2%).

10.
Adv Orthop ; 2022: 4012125, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35449895

RESUMO

Purpose: The purpose of our study was to evaluate the clinical outcome following open reduction and internal fixation of humeral capitellum fractures in adolescents and to assess the usefulness of bioresorbable implants in that procedure. Due to the rarity of these fractures, there are not many studies dealing with the problem in the literature. Methods: We retrospectively evaluated a group of 6 skeletally immature patients aged 10.6-15.3 treated at our department from January 2015 to December 2021. Four type I and two type IV were diagnosed based on the Bryan and Morrey classification. Our patients underwent an open reduction and internal fixation of coronal shear fractures with the use of SmartNail®. Results: All patients were satisfied with the treatment outcome and had full pronation and flexion after surgery. Two patients presented minor deficits of extension and supination compared with the contralateral elbow. At the one-year follow-up, all patients scored 100 on the Mayo Elbow Performance Score. Conclusions: Correct diagnosis and early surgical intervention in humeral capitellum fractures are crucial. That fractures should be anatomically reduced with no articular cartilage damage in order to prevent osteoarthritis. Based on our experience, SmartNail® implant is accurate for the osteochondral fragment fixation.

11.
Ortop Traumatol Rehabil ; 24(3): 201-207, 2022 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-36883426

RESUMO

BACKGROUND: Humeral shaft fractures are relatively rare in the paediatric population. The purpose of our study was to retrospectively evaluate all humeral shaft fractures treated at a children's trauma centre and assess cases involving radial nerve injury. MATERIAL AND METHODS: We retrospectively evaluated a group of 5 skeletally immature patients with radial nerve palsy out of a total of 104 patients with humeral shaft fractures treated in our hospital between January 2011 and December 2021. RESULTS: The study group consisted of four boys and one girl aged 8.6 to 17.2 years (average age 13.6). Mean follow-up duration was 18.4 months. We diagnosed two open and three closed fractures. There were two cases of neurotmesis, two cases of nerve entrapment within the fracture site and one case of neuropraxia. Bone union and functional recovery was achieved in all five patients. CONCLUSIONS: 1. Humeral shaft fractures complicated with radial nerve palsy are a challenging medical problem; 2. The incidence of radial nerve injury in the paediatric population is significantly lower than in adults; in our study, it accounted for 4.8% of all humeral shaft fractures; 3. Expectant observation without nerve exploration is reasonable in fractures caused by a low-energy trauma; 4. Early surgical nerve exploration combined with fracture stabilisation is highly recommended in fractures due to a high-energy trauma.


Assuntos
Fraturas do Úmero , Neuropatia Radial , Adulto , Masculino , Feminino , Humanos , Criança , Adolescente , Neuropatia Radial/epidemiologia , Neuropatia Radial/etiologia , Neuropatia Radial/cirurgia , Estudos Retrospectivos , Incidência , Fraturas do Úmero/complicações , Fraturas do Úmero/cirurgia , Úmero
12.
Ortop Traumatol Rehabil ; 24(4): 251-261, 2022 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-36722498

RESUMO

BACKGROUND: Humeral shaft fractures are relatively rare in children, with incidence between 0.4% and 3% of all fractures in children and between 10% and 20% of all humeral fractures. The purpose of our study was to retrospectively evaluate all humeral shaft fractures treated at children's trauma center from january 2012 till december 2021. MATERIAL AND METHODS: We retrospectively evaluated the group of 104 skeletally immature patients with humeral shaft fracture treated in our hospital. We have analyzed: age; sex; fracture type, management; time of bone healing; final effect and complications. RESULTS: The non-surgical group consisted of 73 patients (27 girls and 46 boys) with an average age of 8.03 (0.6 - 17.7), while the surgical group consisted of 31 patients (16 girls and 15 boys) with an average age of 12.47 (5,7- 17.8). The mean follow-up was 7.65 months (4-12) in non-surgical group, and 13.38 months (4-24) in surgical group. We have analyzed the results statistically, confirming increase the frequency of the above-mentioned fractures and increase the number of patients treated with surgery. We achieved good effect in all patients. CONCLUSIONS: 1. Humeral shaft fractures in children are relatively rare. Although in recent years, we have observed an increase of their frequency; 2. The vast majority of humeral shaft fractures are treated non-surgically with good clinical results; 3. Increase of number of patients treated surgically has been noticeable in the last decade; 4. Surgery is associated with a relatively low risk of complications and allows for cast withdrawal, which significantly improves the patients comfort.


Assuntos
Fraturas do Úmero , Masculino , Feminino , Humanos , Criança , Estudos Retrospectivos , Incidência , Fraturas do Úmero/epidemiologia , Fraturas do Úmero/cirurgia , Úmero , Diáfises
13.
J Anat ; 239(6): 1409-1418, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34254669

RESUMO

Menisci are wedge-shaped cartilage discs that are divided into two parts: the avascular and vascular regions. They are formed by fibrocartilage tissue, which contains round cartilage-like cells and extracellular matrix. Meniscus injury in animals is a common orthopedic problem, but data on the natural healing process mainly deals with the vascular zone. The healing processes in the avascular zone of the meniscus are significantly limited. Thus, this study aimed to evaluate autologous growth plate chondrocytes' impact on the healing process of a damaged meniscus in the avascular zone based on a growing animal model. The study group consisted of 10 pigs at about three months of age. From each animal, chondrocytes from the iliac growth plate and from concentrated bone marrow were taken. Knee joints were divided into right (R) and left (L). The medial meniscus of the R knee joint was treated with a hyaluronic acid based scaffold incubated with bone marrow cells from marrow aspirates (nCHON). The medial meniscus of the L knee joint was treated with a hyaluronic acid based scaffold incubated with bone marrow cells from marrow aspirates supplemented with immature chondrocytes isolated from growth plates (wCHON). The meniscus was damaged in the avascular zone in both knee joints. Followingly, the damaged part of the meniscus was filled with a scaffold with cells from the concentrated bone marrow and from growth plate chondrocytes. In the control group, a scaffold with concentrated bone marrow cells was used. After three months the animals were euthanized and preparations (microscopic slides) were made from the meniscus' damaged part. A qualitative and quantitative analysis have been prepared. The wCHON group in comparison with the nCHON group showed a statistically significantly higher number of fusiform cells on the surface of the graft as well as better healing of the graft. In addition, the degree of vascularization was higher in specimens from the wCHON group than in the nCHON group. The results of our research on immature pig knees revealed that mesenchymal stem cell and growth plate chondrocytes could be treated as the cell source for meniscus reconstruction, and growth plate chondrocytes enhance healing processes in the avascular zone of the injured meniscus.


Assuntos
Menisco , Células-Tronco Mesenquimais , Animais , Condrócitos , Modelos Animais de Doenças , Lâmina de Crescimento , Meniscos Tibiais , Suínos
14.
Ortop Traumatol Rehabil ; 22(3): 173-179, 2020 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-32732445

RESUMO

BACKGROUND: Surgical correction of lower limb discrepancy in children poses a significant clinical problem. The aim of this paper is to present our experience with the PRECICE electromagnetic intramedullary nail. MATERIALS AND METHODS: The study group consisted of 5 patients (2 girls; 3 boys) aged 11.5 to 18 years (mean age 16.3) treated for lower limb discrepancy by femoral lengthening using the PRECICE nail intramedullary system. Average discrepancy was 63 mm (range: 45-74.5 mm). RESULTS: Femoral lengthening was successful in all patients. The femur was lengthened by a mean of 49 mm (range: 40-58 mm). A knee flexion contracture of about 10° occurred in one patient. CONCLUSIONS: 1. Femoral lengthening in children poses a therapeutic challenge. 2. The PRECICE intrame-dullary nail system helps reduce complications and increases patient comfort.


Assuntos
Alongamento Ósseo/legislação & jurisprudência , Alongamento Ósseo/métodos , Pinos Ortopédicos , Fenômenos Eletromagnéticos , Fixadores Externos , Fêmur/cirurgia , Desigualdade de Membros Inferiores/cirurgia , Adolescente , Criança , Feminino , Humanos , Masculino , Estudos Retrospectivos , Resultado do Tratamento
15.
J Orthop Surg Res ; 15(1): 363, 2020 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-32854724

RESUMO

PURPOSE: Managing anterior cruciate ligament (ACL) injuries in skeletally immature patients remains difficult. The main aim of this study was to retrospectively compile normative data on the cross-sectional area (CSA) of the semitendinosus tendon (ST) and the diameter of the ACL in children and young adults. METHODS: Knee magnetic resonance imaging (MRI) examinations were performed for a 2-year period in 132 patients (83 female and 49 male patients). The mean age was 14.9 years (8-18 years). Measurements of the ST CSA were performed on axial views in greyscale by two independent researchers. The ACL diameter was measured as well. RESULTS: The results show the CSA of the ST was related to age, and its growth was not linear. The highest growth rate of the CSA of the ST occurred at age 12-13 at the level of the femoral growth plate and at the level of the tibial plateau. The growth of the ACL diameter was linear until 18 years of age. CONCLUSIONS: ST growth (measured in CSA increments) is almost complete at the age of 13, even though the growth is not linear. ACL growth measured in diameter increments proceeds linearly from 8 to 18 years of age. MRI is a clinically useful tool for assessing hamstring tendon grafts preoperatively. LEVEL OF EVIDENCE: Level III, diagnostic studies.


Assuntos
Lesões do Ligamento Cruzado Anterior/patologia , Lesões do Ligamento Cruzado Anterior/cirurgia , Ligamento Cruzado Anterior/anatomia & histologia , Ligamento Cruzado Anterior/crescimento & desenvolvimento , Tendões/anatomia & histologia , Tendões/crescimento & desenvolvimento , Adolescente , Fatores Etários , Ligamento Cruzado Anterior/diagnóstico por imagem , Reconstrução do Ligamento Cruzado Anterior/métodos , Criança , Feminino , Tendões dos Músculos Isquiotibiais/transplante , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Estudos Retrospectivos , Tendões/diagnóstico por imagem , Fatores de Tempo
16.
J Orthop Surg Res ; 14(1): 260, 2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31416470

RESUMO

BACKGROUND: The treatment of articular cartilage damage is a major clinical problem. More often, this clinical issue affects children, which forces doctors to find the best treatment method. METHODS: The aim of this experimental study on 2-month-old Landrace pigs was to compare the results of two cartilage defect treatments: (1) filling the cartilage defect with a scaffold incubated with bone marrow aspirate supplemented with growth plate chondrocytes (the CELLS group) and (2) filling the cartilage defect with an empty scaffold implanted after drilling the subchondral bone (the CTRL group). The treatment outcomes were assessed macroscopically and microscopically. RESULTS: Based on the macroscopic evaluation, all animals showed a nearly normal morphology, with an average of 9.66/12 points (CTRL) and 10.44/12 points (CELLS). Based on the microscopic evaluation, 1 very good result and 8 good results were obtained in the CTRL group, with an average of 70.44%, while 5 very good results and 4 good results were obtained in the CELLS group, with an average of 79.61%. CONCLUSIONS: (1) Growth plate chondrocytes have high chondrogenic potential and thus offer new possibilities for cartilage cell therapy. (2) The implantation of a scaffold loaded with bone marrow-derived MSCs (mesenchymal stem cells) and growth plate chondrocytes into a cartilage defect is a good therapeutic method in immature patients. (3) Cartilage repair based on a scaffold with bone marrow aspirate-derived cells supplemented with autologous growth plate chondrocytes achieves better results than repair with marrow stimulation and a hyaluronic acid-based scaffold (overall microscopic rating). (4) Chondrocyte clustering is a manifestation of the cartilage repair process but requires further observation.


Assuntos
Cartilagem Articular/fisiologia , Condrócitos/fisiologia , Condrócitos/transplante , Lâmina de Crescimento/fisiologia , Lâmina de Crescimento/transplante , Modelos Animais , Animais , Ácido Hialurônico/administração & dosagem , Células-Tronco Mesenquimais/fisiologia , Suínos , Alicerces Teciduais
17.
Acta Orthop Traumatol Turc ; 51(4): 284-289, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28624480

RESUMO

PURPOSE: The aim of our study was to evaluate thoracic vertebrae rotation in patients with pectus excavatum. Moreover, we wanted to assess the prevalence, the severity and relationship between pectus excavatum and adolescent idiopathic scoliosis (AIS). METHODS: We performed retrospective analysis of 82 preoperative chest CT in children with pectus excavatum performed between January 2008 and December 2011. For each patient Haller Index and Cobb angle was measured. To evaluate the severity of thoracic scoliosis we measured vertebral rotation for Th8 and for vertebra at the level of highest chest deformation using Aaro-Dahlborn method. RESULTS: From the group of 54 patients with pectus excavatum enrolled in the study AIS was diagnosed in 8 patients (14,81%). In patients with symmetric deformation, Th8 rotation was found in 21 patients; the rotation of the apical vertebra was found in 20 patients. In patients with asymmetric deformation Th8 rotation was found in 10 patients; the rotation of the apical vertebra was found in 8 patients. CONCLUSIONS: 1. We have confirmed the higher prevalence of pectus excavatum in boys; 2. We have found a significant relationship between pectus excavatum and adolescent idiopathic scoliosis; 3. We have shown that deformation of the anterior chest wall enforces rotation of the thoracic spine; 4. We haven't found the relationship between the severity of the chest deformity (HI measured) and severity of AIS (Cobb angle measured); 5. We have shown a significant association between HI measured and rotation of thoracic vertebra at the level of highest chest deformation (apical vertebra) in symmetric pectus excavatum. LEVEL OF EVIDENCE: Level IV, Diagnostic study.


Assuntos
Tórax em Funil , Escoliose , Vértebras Torácicas , Anormalidade Torcional/diagnóstico , Adolescente , Criança , Feminino , Tórax em Funil/diagnóstico , Tórax em Funil/epidemiologia , Tórax em Funil/fisiopatologia , Humanos , Masculino , Polônia/epidemiologia , Prevalência , Estudos Retrospectivos , Rotação , Escoliose/diagnóstico , Escoliose/epidemiologia , Escoliose/fisiopatologia , Índice de Gravidade de Doença , Fatores Sexuais , Vértebras Torácicas/diagnóstico por imagem , Vértebras Torácicas/fisiopatologia , Tomografia Computadorizada por Raios X/métodos
18.
Ortop Traumatol Rehabil ; 18(5): 485-496, 2016 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-28102161

RESUMO

BACKGROUND: With the continuous advances in the therapy of joint cartilage injury, some of those classification systems are also being used for evaluating the quality of regenerating cartilage. Histo lo gi cal assessment of joint cartilage is a very important component in the staging of osteoarthritis and tracing therapeutic outcomes. We performed a histological assessment of regenerating growth plate in a group of New Zealand white rabbits as a component of autologous chondrocyte therapy for growth plate damage. MATERIAL AND METHODS: We studied a group of 14 five-week-old in-bred white rabbits. We used a tre phine needle to harvest growth plate from the medial fourth of tibial width. The mean duration of the procedure was 25 minutes (range: 12-37 minutes). We conducted a total of 25 growth plate harvesting procedures. In 21 cases, we placed a drainage tube at the site of the defect for 22 days. After removing the tube, we introduced a cartilago-fibrinous construct containing cultured autologous chondrocytes into 14 defects, while 4 defects were left intact. Three growth plates represented non-intervention controls. RESULTS: Our analysis showed satisfactory graft morphology and integration; absence of inflammatory res ponse and fair restitution of growth plate architecture. CONCLUSIONS: 1. Growth plate damage can lead to the development of an angular deformity as a result of im paired longitudinal bone growth; 2. Autologous chondrocyte grafting is a good method of treatment for growth plate damage; 3. A weakness of autologous chondrocyte grafting is the relatively long time of chondrocyte culturing.


Assuntos
Cartilagem Articular/lesões , Cartilagem Articular/cirurgia , Condrócitos/transplante , Lâmina de Crescimento/cirurgia , Transplante de Tecidos/métodos , Transplantes/crescimento & desenvolvimento , Transplantes/cirurgia , Animais , Feminino , Coelhos
19.
Case Rep Orthop ; 2015: 627502, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26543656

RESUMO

The occipital condyle fracture is rare injury of the craniocervical junction. Meningeal spinal cysts are rare tumors of the spinal cord. Depending on location, these lesions may be classified as extradural and subdural, but extradural spinal cysts are more common. We present the case of a 15-year-old girl who suffered from avulsion occipital condyle fracture treated with use of "halo-vest" system. We established that clinical effect after completed treatment is very good. Control MRI evaluation was performed 12 months after removal of "halo-vest" traction, and clinically silent extradural meningeal spinal cysts were detected at the ventral side of the spinal cord in the cervical segment of the spine. Due to clinically silent course of the disease, we decided to use the conservative treatment. The patient remains under control of our department.

20.
Ortop Traumatol Rehabil ; 17(3): 219-27, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26248623

RESUMO

BACKGROUND: Occipital condyle fractures are rare injuries of the cranio-cervical junction seen more often in adults than in children. They are best diagnosed with CT of the cranio-cervical junction. Treatment depends on the morphology and stability of the fracture. The aim of the present paper was to present cases of occipital condyle fractures treated at our Department, review the literature, and stress the importance of MRI studies in the diagnostic work-up of these injuries. MATERIAL AND METHODS: Our retrospective study involved a group of 3 female patients (mean age was 16.3 years) with occipital condyle fractures diagnosed/treated at our Department. We assessed the cause and type of fracture, additional damage, available classification systems, treatment methods, outcomes and complications. RESULTS: Mean follow-up period was 16 (10-22) months. We achieved good clinical outcomes (NDI scores) in all the patients. In one patient, a follow-up MRI scan revealed the presence of a clinically silent post-traumatic epidural meningeal cyst at the C2-C6 level, anterior to the spinal cord. CONCLUSIONS: CT of the cranio-cervical junction is the best method of diagnosing occipital condyle fractures. 2. The choice of an appropriate treatment method is decisively based on the assessment of the morphology and stability of the fracture in a CT/MRI scan rather than on the fracture type alone. 3. There is no noticeable difference between the usefulness of the classification system developed by Anderson and Montesano and that according to Tuli et al. 4. In our opinion, the system of occipital condyle fracture classification proposed in 2012 does not seem superior in everyday clinical practice. 5. The use of the halo-vest is a good method of treating unstable occipital condyle fractures. 6. Early diagnosis and appropriate treatment of cranio-cervical junction fractures make it possible for the fracture to heal without severe clinical sequelae.


Assuntos
Osso Occipital/diagnóstico por imagem , Osso Occipital/lesões , Fraturas Cranianas/diagnóstico por imagem , Fraturas Cranianas/terapia , Adolescente , Feminino , Seguimentos , Humanos , Imageamento por Ressonância Magnética , Polônia , Estudos Retrospectivos , Resultado do Tratamento
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