RESUMO
Four new acylphloroglucinol derivatives 1, 3, 5 and 13 were isolated from the fruits of Horsfieldia irya, and in addition, thirteen known compounds were also discovered. All compounds were evaluated for cytotoxicity against HeLa and HCT116 cell lines, as well as normal cells (Vero cells). Compound 13 showed cytotoxicity against HeLa and HCT116 cell lines with IC50 values of 4.53 ± 0.05 and 4.53 ± 0.16 µg/mL, respectively, and showed less activity against normal cells (IC50 = 13.38 ± 0.75 µg/mL). Compound 13 may be useful for the development of anticancer agents. It was found that decanoyl side chain may be necessary for the cytotoxicity. The chemical structures of all isolated compounds were elucidated using spectroscopic methods including 1 D-NMR, 2 D-NMR, MS and IR data.
Assuntos
Antineoplásicos Fitogênicos , Myristicaceae , Animais , Antineoplásicos Fitogênicos/farmacologia , Chlorocebus aethiops , Frutas , Células HCT116 , Humanos , Estrutura Molecular , Células VeroRESUMO
Four new benzoyltyramines, atalantums H-K (1-4) and seven known compounds were isolated from the peels of Atalantia monophylla. All compounds were tested for cytotoxicity against HeLa, HCT116 and MCF-7 cell lines, as well as normal cells (Vero cells). Compound 5 showed cytotoxicity against HeLa, HCT116 and MCF-7 cell lines with IC50 values ranging from 16-25 µg/mL but was inactive against Vero cells. Compound 6 also showed interesting results as compound 5 with IC50 values ranging from 15-18 µg/mL and an IC50 value of 80.20 µg/mL against Vero cells. This means compounds 5 and 6 can be used as lead compounds for anticancer agents.