RESUMO
In recent years, the two-dimensional (2D) transition metal dichalcogenides (TMDCs) have attracted renewed interest owing to their remarkable physical and chemical properties. Similar to that of graphene, the atomic thickness of TMDCs significantly limits their optoelectronic applications. In this study, we report a hybrid WS2-optical-fiber-nanowire (WOFN) structure for broadband enhancement of the light-matter interactions, i.e., light absorption, photoluminescence (PL) and second-harmonic generation (SHG), through evanescent field coupling. The interactions between the anisotropic light field of an optical fiber nanowire (OFN) and the anisotropic second-order susceptibility tensor of WS2 are systematically studied theoretically and experimentally. In particular, an efficient SHG in the WOFN appears to be 20 times larger than that in the same OFN before the WS2 integration under the same conditions. Moreover, we show that strain can efficiently manipulate the PL and SHG in the WOFN owing to the large configurability of the silica OFN. Our results demonstrate the potential applications of waveguide-coupled TMDCs structures for tunable high-performance photonic devices.
RESUMO
In order to observe the curative and side effects in malignant hematologic diseases treated with autologous peripheral blood stem cell transplantation (auto-PBSCT) combined with halotype lymphocyte infusion, auto-PBSCs were mobilized, harvested and stored at -196 degrees C from patients in first CR or PR with intensive chemotherapy (Ara-C 1.0 g/m(2) x 5 days or cyclophosphamide 60 mg/kg x 2 days) and G-CSF. Unpurged auto-PBSCs were infused when patients received the conditioning regimen with busulfan, total irradiation or cyclophosphamide. Halotype lymphocytes [mean 5.0 x 10(7)/kg, (4.5 - 6.5) x 10(7)/kg] irradiated with 7.5 Gy were infused to patients when WBCs were more than 1 x 10(9)/L. Hematopoietic recovery and survival of patients were observed. The results showed that in 12 cases accepted this protocol, five patients with acute non-lymphocytic leukemia got to durable remission, of which 2 had durable remission of more than 50 months. One of three patients with non-Hodgkin's lymphoma IVb reached durable remission, and two relapsed and died on 4 and 6 months after treatment, respectively. Two CML patients were also achieved durable remission. One patient with multiple myeloma relapsed on 36 months later, but he still survived disease-free with treatment of thalidomide. In a follow-up survey of 25 months, the disease-free survival was 83%. No severe side effects were observed except platelet delayed recovery after halotype lymphocyte infusion. STR-PCR analysis showed that infused donor lymphocytes disappeared in 3 recipients at 72 hours after infusion. It is concluded that auto-PBSCT combined with halotype lymphocyte infusion could decrease the relapse of malignant hematologic diseases and improve the effect of auto-PBSCT. Recovery of platelet, however, could be delayed by halotype lymphocyte infusion.