Changes in the IGF-1 and TNF-α synthesis pathways before and after three-month reduction diet with low glicemic index in women with PCOS.

OBJECTIVES: An increase in IGF-I and TNF-α may be a cardioprotective effect. To examine the relationships between IGF-I and TNF-α and test the anthropometric and biochemical parameters before and after a low-glycemic index reduction diet using a correlation matrix. MATERIAL AND METHODS: Twenty-two women diagnosed with PCOS according to Rotterdam's criteria were eligible for this study, which analysed the results before and after a three months dietary intervention. Body composition measurements were determined by bioimpedance and performed twice, along with the labelling of lipid, carbohydrate and hormonal profiles. IGF-I and TNF-α were also determined in the serum. RESULTS: Before dietary intervention, a significant correlation was observed. A correlation was also noted between the increase in TNF-α and DHEA-SO4, FSH, glucose level and total cholesterol. The increase in IGF-I was not related to anth-ropometric measurements: however, its concentration was observed to be related to the level of SHBG and HDL. After dietary intervention, the correlation between TNF-α and muscle mass percentage was confirmed, as was the correlation between WHR and fasting blood glucose levels. A significant negative correlation was observed between extracellular water, provided in litres, and SHBG level. CONCLUSIONS: One important role of IGF-I in PCOS pathogenesis is the stimulation of increased synthesis of SHBG and HDL. The increased level of IGF-I after the reduction diet had a cardioprotective effect. TNF-α inhibits FSH synthesis, preventing the growth of numerous follicles. Its synthesis is also related to DHEA-SO4. After three-month reduction diet does not significantly reduce TNF-α.

Studies on the quality nutrition in women with polycystic ovary syndrome (PCOS)

Background: Polycystic ovary syndrome (PCOS) manifests itself with various symptoms, therefore it interests representatives of many medical specializations: general practitioners, gynecologists, endocrinologists, dermatologists, cardiologists and those who deal with metabolic disorders, such as dieticians. Objective: The aim of this study was perform the qualitative assessment of components of diets of women with PCOS as one of the major factor contributing to the disease. Material and Methods: The study was performed on 54 women of childbearing age with PCOS diagnosed according to on the Rotterdam criteria. Qualitative assessment of the diets on the basis of 216 menus was performed based on the analysis of 3-day food diaries and food records taken from the last 24-hour dietary interview. Diets quality assessment was made using three types of point tests: Szewczynski's Diets' classification (SDC), Bielinska's Test with Kulesza's modification (BTK), Healthy Diet Indicator (HDI). Results: Average waist-hip ratio (WHR) and body mass index (BMI) was above the standard 0.91± 0.08 and 29.16 ± 5.8 kg/m2. Qualitative analysis performed with point tests SDC, BT-K and HDI revealed that the majority of the diets were composed inappropriately, containing many mistakes. Statistically significant correlations (Pearson's) were determined between HDI test and the body weight and BMI. When analyzing the type of the meals also the correlations (Spearman's) between BMI and BMI category in BT-K test. Conclusions: Mistakes in diets of women with PCOS are the cause of metabolic disorders related to improper function of ovaries. Native test BT-K seems to be a better method then test SDC and probably HDI of assessing diet in women with PCOS from Poland.

[What is the nutrition regimen followed by athletes after the end of their sporting career?].

Introduction: The aim of this study is to assess the nutritional habits of participants in the research project "CRON -diet as an alternative method for athletes who have completed their sporting career". Materials and methods: 94 former athletes from Poland participated in this study. A standardized Food Frequency Questionnaire was used for interview. Respondents were interviewed once, during the first visit after inclusion in the study. Results: Most former athletes had 3 meals per day during the last 12 months (39.4%), not respecting specified consumption hours (44.7%). The most commonly consumed foods are: whole grain bread, fruits and vegetables. Respondents reported the consumption of these foods several times a week. The study revealed a correlation between the consumption of fruit in general and a preference for apples and pears (r = 0.7340; p < 0.05). Conclusions: The study showed that former athletes' diets are quite diversified. It should be mentioned that former athletes' diets consists of a low number of meals, which are not consumed at fixed times. Respondents were aware that their diet provided too much sugar and fat; some of them declared that they try to reduce the consumption of these products in their daily diet.

[CHANGES IN BODY MASS AND BLOOD LIPID LEVELS IN PATIENTS UNDERGOING CALORIC RESTRICTION]. / ZMIANY MASY CIALA I STEZENIA LIPIDÓW PACJENTÓW PODDANYCH RESTRYKCJOM KALORYCZNYM--DONIESIENIE WSTEPNE.

INTRODUCTION: Caloric restriction is the only well-documented nutritional intervention prolonging the life of mammals. This method modifies the lipid levels in blood, controlling obesity and delaying the onset of many medical conditions associated with metabolic disorders. The aim of the study was to carry out a comparative analysis of lipid profile in patients on Mediterranean or CRON (Caloric Restriction with Optimal Nutrition) diets, before and after six weeks of dieting. MATERIAL AND METHODS: The following parameters were compared: total cholesterol, total lipids, triglycerides, LDL cholesterol, HDL cholesterol, and BMI. Additionally, we measured the levels of insulin, HOMA score, and anthropometric parameters. The comparative analysis demonstrated a statistically significant correlation between mild caloric restriction and blood lipid profile. Results from studies on patients who underwent six-week dietetic intervention indicated statistically significant changes in biochemical parameters due to caloric restrictions. Such changes were not found in subjects following the Mediterranean diet. The greatest decrease in the blood level of triglycerides was found in subjects on the CRON diet, LDL cholesterol, total cholesterol and total lipid levels also decreased. No significant changes if biochemical parameters were found in patients on the Mediterranean diet. CONCLUSIONS: A comparative analysis of all parameters demonstrated that the use of mild caloric restrictions with ensured supply of all necessary nutrients seems to be the most effective solution for reducing fatty tissue.