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1.
Opt Express ; 32(11): 20024-20034, 2024 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-38859121

RESUMO

An optical fiber sensing probe using a composite sensitive film of polyacrylonitrile (PAN) nanofiber membrane and gold nanomembrane is presented for the detection of a carcinoembryonic antigen (CEA), a biomarker associated with colorectal cancer and other diseases. The probe is based on a tilted fiber Bragg grating (TFBG) with a surface plasmon resonance (SPR) gold nanomembrane and a functionalized polyacrylonitrile (PAN) PAN nanofiber coating that selectively binds to CEA molecules. The performance of the probe is evaluated by measuring the spectral shift of the TFBG resonances as a function of CEA concentration in buffer. The probe exhibits a sensitivity of 0.46 dB/(µg/ml), a low limit of detection of 505.4 ng/mL in buffer, and a good selectivity and reproducibility. The proposed probe offers a simple, cost-effective, and a novel method for CEA detection that can be potentially applied for clinical diagnosis and monitoring of CEA-related diseases.


Assuntos
Resinas Acrílicas , Antígeno Carcinoembrionário , Ouro , Nanofibras , Fibras Ópticas , Ressonância de Plasmônio de Superfície , Antígeno Carcinoembrionário/análise , Ouro/química , Nanofibras/química , Ressonância de Plasmônio de Superfície/instrumentação , Ressonância de Plasmônio de Superfície/métodos , Resinas Acrílicas/química , Humanos , Técnicas Biossensoriais/instrumentação , Membranas Artificiais , Nanopartículas Metálicas/química , Reprodutibilidade dos Testes , Tecnologia de Fibra Óptica/instrumentação
2.
Polymers (Basel) ; 16(8)2024 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-38674961

RESUMO

A novel photonic crystal fiber (PCF) sensor for refractive index detection based on polydimethylsiloxane (PDMS) is presented in this research, as well as designs for single-channel and dual-channel structures for this PDMS-PCF sensor. The proposed structures can be used to develop sensors with biocompatible polymers. The performance of the single-channel PDMS-PCF sensor was studied, and it was found that adjusting parameters such as pore diameter, lattice constant, distance between the D-shaped structure and the fiber core, and the radius of gold nanoparticles can optimize the sensor's performance. The findings indicate that the detection range of the single-channel photonic crystal is 1.21-1.27. The maximum wavelength sensitivity is 10,000 nm/RIU with a resolution of 1×10-5 RIU, which is gained when the refractive index is set to 1.27. Based on the results of the single-channel PCF, a dual-channel PDMS-PCF sensor is designed. The refractive index detection range of the proposed sensor is 1.2-1.28. The proposed sensor has a maximum wavelength sensitivity of 13,000 nm/RIU and a maximum resolution of 7.69×10-6 RIU at a refractive index of 1.28. The designed PDMS-PCF holds tremendous potential for applications in the analysis and detection of substances in the human body in the future.

3.
Sensors (Basel) ; 24(8)2024 Apr 09.
Artigo em Inglês | MEDLINE | ID: mdl-38676011

RESUMO

With the in-depth study of solid-state batteries (SSBs), various in situ and ex situ characterization technologies have been widely used to study them. The performance and reliability of SSBs are limited by the formation and evolution of lithium dendrites at the interfaces between solid electrodes and solid electrolytes. We propose a new method based on optical coherence tomography (OCT) for in situ characterization of the internal state of solid-state batteries. OCT is a low-loss, high-resolution, non-invasive imaging technique that can provide real-time monitoring of cross-sectional images of internal structures of SSBs. The morphology, growth, and evolution of lithium dendrites at different stages of cycling under various conditions can be visualized and quantified by OCT. Furthermore, we validate and correlate the OCT results with scanning electron microscopy (SEM) and XPS, proving the accuracy and effectiveness of the OCT characterization method. We reveal the interfacial phenomena and challenges in SSBs and demonstrate the feasibility and advantages of OCT as a powerful tool for in situ and operando imaging of battery interfaces. This study provides new insights into the mechanisms and factors that affect SSB performance, safety, and lifetime, and suggests possible solutions for improvement and application in the field of applied energy.

4.
Polymers (Basel) ; 15(17)2023 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-37688242

RESUMO

In recent years, owing to the continuous development of polymer nanofiber manufacturing technology, various nanofibers with different structural characteristics have emerged, allowing their application in the field of sensing to continually expand. Integrating polymer nanofibers with optical sensors takes advantage of the high sensitivity, fast response, and strong immunity to electromagnetic interference of optical sensors, enabling widespread use in biomedical science, environmental monitoring, food safety, and other fields. This paper summarizes the research progress of polymer nanofibers in optical sensors, classifies and analyzes polymer nanofiber optical sensors according to different functions (fluorescence, Raman, polarization, surface plasmon resonance, and photoelectrochemistry), and introduces the principles, structures, and properties of each type of sensor and application examples in different fields. This paper also looks forward to the future development directions and challenges of polymer nanofiber optical sensors, and provides a reference for in-depth research of sensors and industrial applications of polymer nanofibers.

6.
iScience ; 25(4): 104155, 2022 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-35434561

RESUMO

Metasurfaces provide a promising route for structuring light and generating holograms with designed amplitude, phase, and polarization profiles, leading to a versatile platform for integrating and constructing optical components beyond the conventional ones. At the same time, incorporating coincidence in imaging allows a high signal-to-noise ratio for imaging in very low light levels. As beneficial from the recent development in both metasurfaces and single-photon avalanche diode (SPAD) cameras, we combine the polarization-sensitive capability of metasurfaces with Hong-Ou-Mandel (HOM)-type interference in generating images with tailor-made two-photon interference and polarization coincidence signatures. By using orthogonal linear-polarized photons as incidence, correlated, anticorrelated, and uncorrelated polarization coincidence features can be observed within the same image from the pairwise second-order coherence statistics across different pixels of the image. Our work adds polarization to the demonstrated amplitude and phase sensitivity in the domain of "HOM microscopy" and can be useful for biological and security applications.

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