[Effect of stromal cell derived factor-1α combined with autologous platelet poor plasma on avulsion injury of permanent teeth].

PURPOSE: To explore the therapeutic effect of stromal cell derived factor-1α(SDF-1α) combined with platelet-poor plasma(PPP) on permanent tooth avulsion injury. METHODS: One hundred and forty-four patients with permanent tooth avulsion injuries admitted to Hengshui People's Hospital from March 2020 to March 2022, with a total of 152 affected teeth were included. They were randomly divided into experimental group of 72 cases(76 teeth) and control group of 72 cases(76 teeth). The control group underwent routine replantation surgery, and the root tips were soaked and rinsed with PPP biological solution before surgery. On the basis of the control group, the experimental group implanted SDF-1α into the alveolar fossa before in vitro tooth implantation for treatment. The patients were followed up for 12 months after surgery, the success rate of implantation, degree of postoperative occlusal pain, expression of inflammatory factors in gingival fluid, serum growth factor expression, and incidence of postoperative complications were compared between the two groups. Statistical analysis was performed with SPSS 19.0 software package. RESULTS: The success rate of replantation in the control group was 90.79%(69/76), while the experimental group was 98.68%(75/76). The success rate of replantation in the experimental group was significantly higher than that in the control group(P＜0.05). On the 2nd day, 3 months and 12 months after surgery, the pain scores of the two groups of patients gradually decreased (P＜0.05). There was no significant difference in pain scores between the two groups at each time point(P＞0.05). One month after surgery, the CRP and IL-6 levels in both groups decreased(P＜0.05), while the experimental group was significantly lower than the control group(P＜0.05). The soluble intercellular adhesion factor (sICAM-1) in both groups increased, and the experimental group was significantly higher than the control group (P＜0.05). One month after surgery, vascular endothelial growth factor(VEGF), fibroblast growth factor(FGF), transforming growth factor beta(TGF-ß)and platelet derived growth factor(PDGF) were all elevated, and the experimental group was significantly higher than the control group(P＜0.05). The incidence of postoperative complications in the experimental group was significantly lower than that in the control group(P＜0.05). CONCLUSIONS: The combination of PPP and SDF-1α in treating patients with permanent tooth avulsion injury has a high success rate of delayed replantation and a low incidence of postoperative adverse reactions.

Efficacy of calcium hydroxide and chlorhexidine in pulp revascularization after trauma in young permanent teeth.

The objective of this study is to observe and analyze the efficacy of calcium hydroxide and chlorhexidine in pulp revascularization after trauma in young permanent teeth. A total of 120 patients who were treated in our hospital for pulp revascularization after trauma in young permanent teeth were enrolled as research objects in the study. The patients were treated with calcium hydroxide and chlorhexidine and the overall treatment efficiency was statistically observed. The improvement in various indicators before and after treatment was observed, including pain symptom score, gum swelling symptom score, tooth looseness score. The overall treatment efficiency was recorded. The results showed that there were 70 cases of significant effective treatment, 42 cases of effective treatment, and 8 cases of ineffective treatment, respectively, with overall treatment efficiency of 93.33%. Compared with the pain score, gum swelling score and teeth looseness score before treatment, these indicators showed a significant improvement after treatment, p<0.05. The application of calcium hydroxide and chlorhexidine during pulp revascularization after trauma in young permanent teeth can significantly improve the therapeutic effect and achieve higher therapeutic efficiency, demonstrating huge application value.