Antibiotics use and drug resistance analysis of neurology patients' Infection.

Recent studies have shown that nosocomial infection is an important factor affecting the quality and service level of neurology. Based on the characteristics of neurology patients, the application of antibacterial drugs has certain particular characteristic. In this paper, we analyzed the distribution of pathogenic bacteria in neurology patients in 2016-2017 year, and made statistics on the utilization of antibiotics. The results showed that 84 strains of pathogenic bacteria were isolated from the neurology department, including Gram-negative bacteria (44 strains, 52.38%), Gram-positive bacteria (31, 36.9%), and fungi (9, 10.71%). At the same time, as for the use of antibiotics, the drug category is most cephalosporins and the top 5 antiseptic drugs are cephalosporins, beta lactamase inhibitors, quinolones, aminosides and penicillins. The highest DUI (drug utilization index) value was for cefoperazone tazobactam (1.33), followed by ceftriaxone Mino (1.20) and ciprofloxacin (1.18). Clinicians should guide the selection of antimicrobial agents based on the results of etiological examination, and formulate a reasonable treatment plan based on the characteristics of patients, common pathogens and drug resistance.

Association of HLA-B*51:01 with papillary thyroid carcinoma in the Chinese Han population of the Shandong coastal areas.

BACKGROUND: A lot of work has been done to study the association between human leukocyte antigen (HLA) and papillary thyroid carcinoma (PTC) in various populations. But the results of the currently available studies are not consistent. The aim of this study was to evaluate the association of HLA-A, -B, -C, -DRB1, and -DQB1 with PTC in the Chinese Han population of the coastal areas of Shandong Province with respect to age and sex. METHODS: A total of 154 patients diagnosed with PTC were analyzed for HLA-A, -B, -C, -DRB1, and -DQB1 alleles by using a polymerase chain reaction sequence-based typing (PCR-SBT) method. Two hundred unrelated healthy individuals were typed as controls. RESULTS: Compared with the controls, the HLA-B*51:01 (8.8% vs. 4.5%, p=0.029, OR 2.039 [CI 1.101-3.775]) and HLA-C*07:06 (2.6% vs. 0.5%, p=0.024, OR 5.307 [CI 1.119-25.171]) allele frequencies were higher in the PTC patients, while the HLA-C*07:01 (1.3% vs. 6.0%, p=0.001, OR 0.206 [CI 0.071-0.601]) allele frequency was lower in the PTC patients that did not persist after Bonferroni correction for multiple tests. This showed no statistically significant correlation of the HLA-A, -DRB1, and -DQB1 alleles and PTC. The incidence of PTC was more frequent in females between 30 and 60 years old. There were no significant differences in the age and sex distributions between the total and the HLA-B*51:01 positive PTC patients. CONCLUSIONS: The HLA associations in this Chinese Han population differ markedly from studies done in Europeans and Caucasians. The results reveal that HLA-B*51:01 is more likely to be a susceptible allele for PTC in addition to age and sex in the coastal areas of Shandong Province.

Evaluation of the correlation between genetic damage and occupational chromate exposure through BNMN frequencies.

OBJECTIVE: To evaluate the correlation between chromate exposure and binucleated cells with micronuclei (BNMN) frequencies in chromate production workers and explore the ideal biomarker to detect early DNA damage. METHODS: There are 79 workers and 112 peasants in this study. Chromium concentrations in the air (CrA), blood (CrB), and urine (CrU) were detected. BNMN frequencies were also counted. RESULTS: The CrA, CrB, CrU, and BNMN frequencies of the exposure group were higher than those of the control group; BNMN frequencies were positively correlated with CrB and CrU; natural logarithm (Ln) BNMN was regressed on CrB, CrU, and CrA by linear models. CONCLUSIONS: The increases in CrB, CrU, and BNMN frequencies caused by lower CrA level suggest BNMN frequencies could be used to detect early DNA damage in the chromate production health surveillance.

Synchronous recording of intracranial and extracranial EEG in temporal lobe epilepsy.

PURPOSE: To explore the diagnostic value of intracranial electrodes in highly suspected temporal lobe epilepsy (TLE) and the value of sphenoid electrodes (PG) and the propagation patterns of ictal discharges in focus lateralization. METHODS: Intracranial electrodes were implanted in 22 probable TLE patients through bilateral temporal burr holes. Extracranial electrodes included the 10-20 international EEG system and bilateral PGs. Intracranial and extracranial EEGs (IEEG, EEEG) were synchronously recorded. The interictal epileptic discharges (IEDs) were counted for 3h of interictal preoperative long-playing video EEG. Time intervals between electrodes recording the ictus and ictus occurring were measured and the propagation patterns were deduced. RESULTS: By IEEG, 18 patients with confirmed TLE had surgery; 14 were seizure-free. 3 had FLE, and 1, uncertain localization. Of the 14 TLE and postoperative seizure-free patients, the ratio (left:right) of IEDs in the 3h interictal EEG was 483:211 in the 6 left TLE and 263:654 in the 8 right TLE. In 12 of the 14 cases, the side with more IEDs at PG was the epileptic focus side. In 11 of the 14 cases the earlier PG recording side was focus side. We found that the propagation sequence of ictus followed certain rules in most attacks. CONCLUSIONS: The results indicated that IEEG was useful for final diagnosis of highly suspected TLE and that PG was helpful in focus lateralization. The propagation patterns of ictus might provide a new tool in focus lateralization and localization.