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Respiratory signals are critical clinical diagnostic criteria for respiratory diseases and health conditions, and respiratory sensors play a crucial role in achieving the desired respiratory monitoring effect. High sensitivity to a single factor can improve the reliability of respiratory monitoring, and maintaining the hygiene of the sensors is also important for daily health monitoring. Herein, we propose a flexible Au-modified anatase titanium dioxide resistive respiratory sensor, which can be mechanically compliantly attached to curved surfaces for respiratory monitoring in different modalities (i.e., respiratory intensity, frequency, and rate). The uniform and preferentially oriented anatase titanium dioxide films gained by the polymer-assisted deposition technique can be fabricated on flexible substrates through a liquid-assisted transferring process. The Au modification can enhance surface plasmon resonance to facilitate the photocatalytic activity of titanium dioxide, and the optimized distribution of Au on the surface of titanium dioxide film made the sensor have an excellent antibacterial effect. The uniquely designed encapsulation can effectively control the contact between the surface of titanium dioxide films and electrodes, allowing the flexible sensor to exhibit fast response time (0.71 s) and recovery time (1.06 s) to respiratory as well as insensitivity or low sensitivity to other factors (i.e., gas composition, humidity, temperature, stress, and strain). This work provided an effective strategy for flexible wearable respiratory sensors and has great potential in daily respiratory monitoring for health management and pandemic control.
Assuntos
Antibacterianos , Titânio , Reprodutibilidade dos Testes , Titânio/farmacologia , Titânio/química , Antibacterianos/farmacologia , Antibacterianos/químicaRESUMO
The concentration of dopamine (DA) and tyrosine (Tyr) reflects the condition of patients with Parkinson's disease, whereas moderate paracetamol (PA) can help relieve their pain. Therefore, real-time measurements of these bioanalytes have important clinical implications for patients with Parkinson's disease. However, previous sensors suffer from either limited sensitivity or complex fabrication and integration processes. This work introduces a simple and cost-effective method to prepare high-quality, flexible titanium dioxide (TiO2) thin films with highly reactive (001)-facets. The as-fabricated TiO2 film supported by a carbon cloth electrode (i.e., TiO2-CC) allows excellent electrochemical specificity and sensitivity to DA (1.390 µA µM-1 cm-2), Tyr (0.126 µA µM-1 cm-2), and PA (0.0841 µA µM-1 cm-2). More importantly, accurate DA concentration in varied pH conditions can be obtained by decoupling them within a single differential pulse voltammetry measurement without additional sensing units. The TiO2-CC electrochemical sensor can be integrated into a smart diaper to detect the trace amount of DA or an integrated skin-interfaced patch with microfluidic sampling and wireless transmission units for real-time detection of the sweat Try and PA concentration. The wearable sensor based on TiO2-CC prepared by facile manufacturing methods holds great potential in the daily health monitoring and care of patients with neurological disorders.
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Acetaminofen , Dopamina , Técnicas Eletroquímicas , Titânio , Tirosina , Dispositivos Eletrônicos Vestíveis , Titânio/química , Acetaminofen/análise , Dopamina/análise , Tirosina/química , Técnicas Eletroquímicas/métodos , Humanos , Eletrodos , Técnicas Biossensoriais/métodos , Técnicas Biossensoriais/instrumentaçãoRESUMO
With the vigorous development of intelligent medical care and interdisciplinary science, innovative flexible bioelectronics (FBEs) are emerging in health monitoring, disease diagnosis and treatment, and even cancer therapy. This work comments on the recent progress of FBEs in personalized health management, emphasizing its innovative role in cancer therapy. Future perspectives on the challenges and opportunities for the next-generation innovative FBEs are also proposed.
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Malocclusion is a prevalent dental health problem plaguing over 56% worldwide. Mechanical orthodontic aligners render directional teeth movement extensively used for malocclusion treatment in the clinic, while mechanical regulation inefficiency prolongs the treatment course and induces adverse complications. As a noninvasive physiotherapy, an appropriate electric field plays a vital role in tissue metabolism engineering. Here, we propose an occlusion-activated electromechanical synergistic dental aligner that converts occlusal energy into a piezo-excited alternating electric field for accelerating orthodontic tooth movement. Within an 18-day intervention, significantly facilitated orthodontic results were obtained from young and aged Sprague-Dawley rats, increasing by 34% and 164% in orthodontic efficiency, respectively. The different efficiencies were attributed to age-distributed periodontal tissue status. Mechanistically, the electromechanical synergistic intervention modulated the microenvironment, enhanced osteoblast and osteoclast activity, promoted alveolar bone metabolism, and ultimately accelerated tooth movement. This work holds excellent potential for personalized and effective treatment for malocclusions, which would vastly reduce the suffering of the long orthodontic course.
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Má Oclusão , Técnicas de Movimentação Dentária , Ratos , Animais , Ratos Sprague-Dawley , Eletricidade , Engenharia , Má Oclusão/terapiaRESUMO
The cornea is a tissue susceptible to various injuries and traumas with a complicated cascade repair process, in which conserving its integrity and clarity is critical to restoring visual function. Enhancing the endogenous electric field is recognized as an effective method of accelerating corneal injury repair. However, current equipment limitations and implementation complexities hinder its widespread adoption. Here, we propose a snowflake-inspired, blink-driven flexible piezoelectric contact lens that can convert mechanical blink motions into a unidirectional pulsed electric field for direct application to moderate corneal injury repair. The device is validated on mouse and rabbit models with different relative corneal alkali burn ratios to modulate the microenvironment, alleviate stromal fibrosis, promote orderly epithelial arrangement and differentiation, and restore corneal clarity. Within an 8-day intervention, the corneal clarity of mice and rabbits improves by more than 50%, and the repair rate of mouse and rabbit corneas increases by over 52%. Mechanistically, the device intervention is advantageous in blocking growth factors' signaling pathways specifically involved in stromal fibrosis whilst preserving and harnessing the signaling pathways required for indispensable epithelial metabolism. This work put forward an efficient and orderly corneal therapeutic technology utilizing artificial endogenous-strengthened signals generated by spontaneous body activities.
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Lentes de Contato , Lesões da Córnea , Animais , Coelhos , Córnea/metabolismo , Lesões da Córnea/terapia , Lesões da Córnea/metabolismoRESUMO
This article describes the implementation of a wireless human motion detection with interference resistance to untargeted deformations based on a stretchable patch antenna with fractal design. By rationally incorporating the Hilbert fractal pattern in the conductive patch and ground plane, the patch antenna shows a mechanical stretchability of â¼40% and a maximum gain of 2.95 dB at 2.5 GHz. Furthermore, the influence of the fractal order on the mechanical stretchability and radiation properties of the stretchable patch antenna is discussed. The resonant frequency of the stretchable fractal antenna demonstrates highly selective sensitivity to different deformations; i.e., it remains almost unchanged with bending deformations and is linearly dependent on the tensile strain. Remote detection of joint motions is experimentally verified by a wireless on-body strain sensor based on the fractal design-based stretchable microstrip antenna.
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As a non-invasive innovative diagnosis platform, advanced flexible contact lenses can dynamically monitor vital ocular indicators, spot abnormalities and provide biofeedback guidance for real-time diagnosis and rehabilitation tracking of chronic eye diseases. However, most of the state-of-the-art reported contact lenses either can only monitor a single indicator at a time or realize multifunctional integration based on multiple materials. Herein, we developed a flexible multifunctional contact lens based on inorganic γ-Fe2O3@NiO magnetic oxide nanosheets, which can be attached conformally and seamlessly to the eyeball to simultaneously monitor glucose level in tears, eyeball movement, and intraocular pressure. The optimized contact lens has a reliable glucose detection limit (0.43 µmol), superior eye movement measurement accuracy (95.27%) and high intraocular pressure sensitivity (0.17 MHz mmHg- 1). This work presents a concept in the biochemical and biophysical integrated sensing of ocular signals using contact lens via an innovative material, and provides a personalized and efficient way for health management.
Assuntos
Lentes de Contato , Óxidos , Glucose , Fenômenos Magnéticos , Tonometria OcularRESUMO
Rationally designing high-efficiency catalysts for the oxygen evolution reaction (OER) is extremely important for developing sustainable energy technologies, but remains a major research challenge. In this paper, a Co/Fe-imidazole-based bimetal-organic framework nanosheet array grown on a nickel foam [MIL-53(Co-Fe)/NF] was prepared via a facile solvothermal process. Surprisingly, MIL-53(Co-Fe)/NF shows excellent OER activity with overpotential as low as 262 mV at 100 mA cm-2, much lower than those of the single metal-based MOFs, and even comparable to that of the precious RuO2. The results indicate that the synergetic effect of co-doped Fe and Co makes a crucial contribution to the high activity of the bimetal-based MOF catalyst. Additionally, this catalyst also displays outstanding long-term electrochemical durability for at least 80 h.
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It is highly desirable to develop efficient and durable oxygen evolution reaction (OER) electrocatalysts. Herein, we report the in situ development of an Fe-(tetracyanoquinodimethane)2 nanowire array on Fe foil (Fe(TCNQ)2/Fe) via a solution immersion method. As a non-noble-metal OER electrocatalyst, such Fe(TCNQ)2/Fe needs an overpotential of only 340 mV to drive a geometrical catalytic current density of 10 mA cm-2 in 1.0 M KOH. Notably, it also shows strong long-term electrochemical durability capable of maintaining its catalytic activity for at least 110 h.
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The development of earth-abundant catalysts toward high-efficient and durable oxygen evolution reaction (OER) electrocatalysis in the carbonate electrolyte is in great demand but remains a huge challenge. In this communication, we describe the development of a Co-carbonate-hydroxide nanowire array on nickel foam (CoCH/NF) via in situ electrochemical conversion of the Co(CO3)0.5(OH)·0.11H2O nanowire array. When utilized as a 3D catalyst electrode for the OER in 1.0 M KHCO3 (pH: 8.3), as-formed CoCH/NF demands overpotential of only 332 mV to drive a geometrical catalytic current density of 10 mA cm-2, with its catalytic activity being maintained for at least 130 h. Impressively, it also demonstrates a high turnover frequency value of 0.22 mol O2 s-1 at an overpotential of 500 mV.