Binding dynamics of cavity solitons in a Kerr resonator with high order dispersion.

Cavity solitons are persistent light pulses arising from the externally driven Kerr resonators. Thanks to the passive parametric gain, cavity soliton has been endowed with the natural advantage of the chip-scaled integration since it was first experimentally generated in the fiber-based platform. Deterministic single soliton with smooth spectrum is a preferred state for numerous applications. However, multiple solitons are more common in the resonators with anomalous dispersion. In this condition, adjacent solitons are easily perturbed to attract and collide with each other. Some experimental observations deviated from the aforementioned description have recorded the stable soliton intervals that can last for a long time scale. This phenomenon is known as soliton binding and is attributed to the presence of narrow resonant sidebands in the spectrum. While the stationary configuration of two binding solitons has been investigated, the dynamical evolution remains an area for further exploration. In this paper, we discuss the binding dynamics of the cavity solitons in the presence of high-order dispersion. The proposed theoretical predictions match well with the numerical results, encompassing both the stationary stable intervals and dynamic trajectories. Our research will provide a comprehensive insight into the soliton motion induced by the internal perturbations.

Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances.

Cancer remains the leading cause of death around the world. In cancer treatment, over 50% of cancer patients receive radiotherapy alone or in multimodal combinations with other therapies. One of the adverse consequences after radiation exposure is the occurrence of radiation-induced tissue fibrosis (RIF), which is characterized by the abnormal activation of myofibroblasts and the excessive accumulation of extracellular matrix. This phenotype can manifest in multiple organs, such as lung, skin, liver and kidney. In-depth studies on the mechanisms of radiation-induced fibrosis have shown that a variety of extracellular signals such as immune cells and abnormal release of cytokines, and intracellular signals such as cGAS/STING, oxidative stress response, metabolic reprogramming and proteasome pathway activation are involved in the activation of myofibroblasts. Tissue fibrosis is extremely harmful to patients' health and requires early diagnosis. In addition to traditional serum markers, histologic and imaging tests, the diagnostic potential of nuclear medicine techniques is emerging. Anti-inflammatory and antioxidant therapies are the traditional treatments for radiation-induced fibrosis. Recently, some promising therapeutic strategies have emerged, such as stem cell therapy and targeted therapies. However, incomplete knowledge of the mechanisms hinders the treatment of this disease. Here, we also highlight the potential mechanistic, diagnostic and therapeutic directions of radiation-induced fibrosis.

Improved Differential Evolution Algorithm for Sensitivity Enhancement of Surface Plasmon Resonance Biosensor Based on Two-Dimensional Material for Detection of Waterborne Bacteria.

Due to the large number of waterborne bacteria presenting in drinking water, their rapid and accurate identification has become a global priority. The surface plasmon resonance (SPR) biosensor with prism (BK7)-silver(Ag)-MXene(Ti3T2Cx)-graphene- affinity-sensing medium is examined in this paper, in which the sensing medium includes pure water, vibrio cholera (V. cholera), and escherichia coli (E. coli). For the Ag-affinity-sensing medium, the maximum sensitivity is obtained by E. coli, followed by V. cholera, and the minimum is pure water. Based on the fixed-parameter scanning (FPS) method, the highest sensitivity is 246.2 °/RIU by the MXene and graphene with monolayer, and with E. coli sensing medium. Therefore, the algorithm of improved differential evolution (IDE) is obtained. By the IDE algorithm, after three iterations, the maximum fitness value (sensitivity) of the SPR biosensor achieves 246.6 °/RIU by using the structure of Ag (61 nm)-MXene (monolayer)-graphene (monolayer)-affinity (4 nm)-E. coli. Compared with the FPS and differential evolution (DE) algorithm, the highest sensitivity is more accurate and efficient, and with fewer iterations. The performance optimization of multilayer SPR biosensors provides an efficient platform.

Cavity soliton in a cyclic polarization permutation fiber resonator.

Cavity solitons are shape-preserving waveforms infinitely revolving around a cavity, which have numerous applications from spectroscopy to telecommunications. Although the cavity solitons have been widely studied for their special time-frequency characteristics over the past decade, the spectral flatness will be a large limitation in some applications without any extra filtering process. In this paper, we report on the generation of a distinct cavity soliton in a cyclic polarization permutation fiber resonator. With the simultaneous excitation of two orthogonal polarization modes with equally opposite dispersion, vectorial cavity solitons possessing broader and flatter spectra can be generated. In order to verify the concept, a numerical model of the polarization-maintaining fiber is proposed and the soliton with a flattened spectrum can be formed. The results enrich the soliton dynamics in the vectorial dissipation system.

Linear optical sampling enabled soliton nonlinear frequency spectrum classification.

Nonlinear Fourier transform (NFT) is a powerful tool for characterizing optical soliton dynamics, which, however, suffers from fundamental limitations that ultra-wide bandwidth photodetectors and ultra-high sampling rate analog-to-digital converters should be used when accessing the full-field information of an ultrafast optical pulse. Herein, we report on the experimental demonstration of the linear optical sampling (LOS) enabled nonlinear frequency spectrum classification of ultrashort optical pulses, which could break this limitation. Instead of traditional coherent detection, the LOS overcomes the ultra-wide bandwidth constraint of commercially available optoelectrical devices. By finely adjusting the repetition rate difference between the soliton to be characterized and the sampling pulsed source, a 55.56-TSa/s equivalent sampling rate arising in the LOS can be secured, where only 400-MHz balanced photodetectors and 5-GSa/s analog-to-digital converter are used. Meanwhile, according to the nonlinear frequency spectrum calculated from the accurate full-field information, the promising concept of soliton distillation has been experimentally verified for the first time. The LOS-enabled NFT technique provides an alternative and efficient characterization tool for ultrafast fiber lasers, which facilities comprehensive insight into soliton dynamics.

Dynamics of cavity soliton driven by chirped optical pulses in Kerr resonators.

Recent researches have demonstrated that pulsed driving is an effective method to increase the temporal overlap between cavity soliton (CS) and pump field, thereby increasing the pump-to-comb conversion efficiency. The amplitude-modulated inhomogeneity of the background wave causes the solitons to drift toward edges of the driving pulse. To eliminate the multiple temporal trapping positions, induced by the spontaneous symmetry breaking, we propose the chirped pulse driving for deterministic single soliton generation. We theoretically explain the physical mechanism of the chirp pulse driving, as the combination of amplitude and phase modulation. Our numerical simulations demonstrate the chirp is responsible for the single soliton generation. A detailed investigation for dynamics of CSs sustained by chirped pulses, shows the recovery of spontaneous symmetry breaking. In addition, the desynchronized chirped pulse driving is also considered here. Considering a weak chirp parameter, the desynchronization-dependent trapping position diagram is divided into multiple areas including two CSs, a single CS, two oscillating CSs, and no CS. With a sufficient chirp parameter considered, the trapping position curve becomes a monotonous function of the desynchronized drift velocity, which indicates deterministic single soliton generation.

L-band compact Q-switched fiber laser based on a thulium-doped fiber saturable absorber.

In this paper, a compact and stable Q-switched erbium-doped fiber laser operating at around 1600 nm by employing a segment of 1-cm thulium-doped fiber saturable absorber (TDF-SA) is proposed. When the pump power is adjusted between 28 and 71 mW, the Q-switched operation can be maintained stably, and the output power increases from 74 µW to 2.6 mW. Furthermore, the peak power clamping effect is also observed when the pump power exceeds 60 mW. The structure of the cavity is greatly simplified by using all-optical and hybrid fiber components, which contributes to its long-term stability. Our results prove that the TDF can be a promising SA for all-fiber Q-switched pulses generation in the L-band.

Comparison of the sensitivity by SPR in a metal-ITO-BlueP/TMDC structure.

A surface plasmon resonance (SPR) sensor based on blue phosphorus (BlueP)/transition metal dichalcogenides (TMDCs) of two-dimensional (2D) materials is proposed to increase the performance. In this sensor, BlueP/TMDCs are coated on indium tin oxide (ITO) and different metals (Au/Ag/Cu) to improve the sensitivity. By optimizing structural parameters, with the BlueP/WS2 monolayer and Au thin film, the angular sensitivity can reach as high as 226.0°/RIU. The phase sensitivity also can be as high as 3.6001×106deg/RIU with BlueP/MoS2 4 layers, 228 nm ITO, and 25 nm Au thin film, which is 6.77 times that of the Au-ITO structure and 54.40 times that of the traditional SPR of Au thin film. The SPR sensor has potential applications in disease diagnosis, drug development, gene sequencing and treatment, environmental monitoring, food safety testing, doping testing, and other fields.

Improved particle swarm optimization algorithm for high performance SPR sensor design.

The surface plasmon resonance (SPR) sensor offers high sensitivity, good stability, simple structure, and is label-free. However, optimizing a multi-layered structure is quite time-consuming within the SPR sensor design process. Moreover, it is easy to overlook optimal design when using the conventional parameter sweeping method. In this paper, the improved particle swarm optimization (IPSO) algorithm with high global optimal solution convergence speed is applied for this purpose. Based on the IPSO algorithm, the SPR sensor with transition metal dichalcogenides (TMDCs) and graphene composite is proposed and optimized. The results show that the best Ag-ITO-WS2-graphene hybrid structure can be found by the IPSO algorithm, and the maximum sensitivity is 137.4°/RIU, and the figure of merit (FOM) is 5.25RIU-1. Compared with the standard particle swarm optimization algorithm, the number of iterations can be reduced. The development of the SPR sensor provides an optimization platform, which enormously improves the development efficiency of the multi-layer SPR sensor.

Design and experimental study of a sensitization structure with fiber grating sensor for nonintrusive pipeline pressure detection.

With the extensive applications of pressure pipelines in various fields, research on pipeline pressure nonintrusive detection technology has become a promising measurement technology and development trend. In this study, taking a pressure pipeline as the research object, a wall strain sensitization structure with a nonintrusive fiber Bragg grating (FBG) pressure sensor was proposed. First, the strain characteristics of the pipeline wall under internal pressure were analyzed in detail. Then, a nonintrusive strain-amplifying structure with a rhomboid structure as the core was designed in accordance with the linear relationship between the strain of the pipeline wall and the pressure inside the pipeline. The designed structure can enlarge and transmit the pipeline wall strain to the strain beam of the rhomboid structure. Next, simulation models for the pipeline, sensitization structure, and detection system were established. Afterward, a series of structural optimization tasks were performed. Simulation results of the analysis of the sensitization structure with different sizes show that the sensitization structure of the FBG sensor can amplify the strain of the pipeline wall several times. Besides, the test results indicate that the sensitized structure with a long diagonal of approximately 2.5 times the short diagonal and the rhomboid structure material of 7075 aluminum alloy has a more stable and effective transmission and amplification effect on the wall strain. Moreover, it can effectively amplify the measurement signal and has a high application value.

Comparison of transcriptional profiles between CD4+ and CD8+ T cells in HIV type 1-infected patients.

The CD4+/CD8+ T cell ratio is altered when HIV-1 infects the human immune system. However, the exact mechanisms of how CD4+ and CD8+T cells participate in HIV infection are still unknown. This study used bioinformatics methods to compare the transcriptional profiles between CD4+ and CD8+ T cells in HIV-1-infected patients in order to explore the potential molecular mechanisms of CD4+ and CD8+ T cells in HIV-1 infection. We found that expression patterns of differentially expressed genes (DEG) in CD4+T cells were dramatically different from those in CD8+ T cells. We also constructed protein-protein interaction (PPI) networks to extract functional modules at each stage, and found that some of the important genes such as BRCA1 were central hubs of the modules. Finally, we applied functional annotation to the modules and found that CD4+/CD8+ T cells played critical roles in regulating the cell cycle and other cellular pathways. Thus, this study would greatly further our understanding of the roles of T cells in HIV infection, and provide potential clues for developing AIDS vaccines in the future.